• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 3. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
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• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
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• 5. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Introduction to 2-(1-methylethyl)-4-Pyridinamine (CAS No. 340006-70-4)

2-(1-methylethyl)-4-Pyridinamine, also known by its CAS number 340006-70-4, is a significant compound in the field of medicinal chemistry and pharmaceutical research. This compound belongs to the class of pyridine derivatives and has garnered attention due to its potential therapeutic applications and unique chemical properties. In this comprehensive introduction, we will delve into the structural characteristics, synthesis methods, biological activities, and recent research advancements related to 2-(1-methylethyl)-4-Pyridinamine.

Structural Characteristics

The molecular formula of 2-(1-methylethyl)-4-Pyridinamine is C₈H₁₃N₂, and its molecular weight is approximately 135.2 g/mol. The compound features a pyridine ring with a 1-methylethyl group (isopropyl) attached at the 2-position and an amine group at the 4-position. The presence of these functional groups imparts unique chemical and physical properties to the molecule, making it an interesting subject for both academic and industrial research.

Synthesis Methods

The synthesis of 2-(1-methylethyl)-4-Pyridinamine can be achieved through various routes, each with its own advantages and limitations. One common method involves the reaction of 2-chloro-4-pyridine with isopropylamine in the presence of a suitable base, such as potassium carbonate. This reaction typically proceeds via nucleophilic substitution, leading to the formation of the desired product. Another approach involves the catalytic hydrogenation of a corresponding nitro compound, followed by reductive amination to introduce the amine functionality.

Biological Activities

2-(1-methylethyl)-4-Pyridinamine has been studied for its potential biological activities, particularly in the context of pharmaceutical development. Recent research has shown that this compound exhibits significant anti-inflammatory and analgesic properties, making it a promising candidate for the treatment of various inflammatory conditions and pain management. Additionally, studies have indicated that 2-(1-methylethyl)-4-Pyridinamine may have neuroprotective effects, which could be beneficial in treating neurodegenerative diseases such as Alzheimer's and Parkinson's.

Clinical Trials and Research Advancements

The therapeutic potential of 2-(1-methylethyl)-4-Pyridinamine has led to several clinical trials aimed at evaluating its safety and efficacy in human subjects. Preliminary results from phase I trials have demonstrated that the compound is well-tolerated at various dose levels, with no significant adverse effects reported. Phase II trials are currently underway to further investigate its therapeutic benefits in specific patient populations.

In addition to clinical trials, ongoing research is focused on optimizing the pharmacokinetic properties of 2-(1-methylethyl)-4-Pyridinamine. Scientists are exploring prodrug strategies and formulation techniques to enhance its bioavailability and reduce potential side effects. These efforts are crucial for advancing the compound from preclinical stages to clinical applications.

Mechanism of Action

The biological activities of 2-(1-methylethyl)-4-Pyridinamine are attributed to its ability to modulate key signaling pathways involved in inflammation and pain perception. Specifically, it has been shown to inhibit the production of pro-inflammatory cytokines such as TNF-α and IL-6, which are known to play a central role in chronic inflammatory conditions. Furthermore, the compound may interact with specific receptors or enzymes in the central nervous system, contributing to its analgesic effects.

FUTURE DIRECTIONS AND CONCLUSIONS

The continued investigation of 2-(1-methylethyl)-4-Pyridinamine (CAS No. 340006-70-4) holds great promise for advancing our understanding of its therapeutic potential. Future research will likely focus on elucidating its precise mechanism of action, optimizing its pharmacological properties, and conducting larger-scale clinical trials to validate its efficacy in diverse patient populations.

In conclusion, 2-(1-methylethyl)-4-Pyridinamine is a versatile compound with a wide range of potential applications in medicine. Its unique chemical structure and biological activities make it an exciting area of study for researchers and pharmaceutical companies alike. As more data becomes available from ongoing studies, it is anticipated that this compound will play a significant role in the development of novel therapeutic agents for various medical conditions.

• 732979-10-1(3,4-Pyridinediamine,6-(1-methylethyl)-)
• 405103-02-8(6-Isopropylpyridin-3-amine)
• 849226-50-2(2-ethyl-6-methyl-pyridin-4-ylamine)
• 1159818-59-3(2-Cyclobutylpyridin-4-amine)
• 50826-64-7(2-ethylpyridin-4-amine)
• 144291-54-3(2,6-Diethylpyridin-4-amine)
• 1446509-65-4(2-(4-Aminopyridin-2-yl)-2-methylpropanenitrile)
• 1599386-26-1(4-Hydrazinyl-2-isopropylpyridine)
• 340006-71-5(2-cyclopropylpyridin-4-amine)
• 39919-69-2(2-(1,1-Dimethylethyl)-4-pyridinamine)