Cas no 1159818-59-3 (2-Cyclobutylpyridin-4-amine)
2-Cyclobutylpyridin-4-amine Chemical and Physical Properties
Names and Identifiers
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- 4-Pyridinamine, 2-cyclobutyl-
- 2-cyclobutylpyridin-4-amine
- 2-Cyclobutyl-4-pyridinamine
- 4-Amino-2-cyclobutylpyridine
- 2-Cyclobutylpyridin-4-amine
-
- Inchi： 1S/C9H12N2/c10-8-4-5-11-9(6-8)7-2-1-3-7/h4-7H,1-3H2,(H2,10,11)
- InChI Key： MOCNNCUFQABJNB-UHFFFAOYSA-N
- SMILES： N1C=CC(=CC=1C1CCC1)N
Computed Properties
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 11
- Rotatable Bond Count: 1
- Complexity: 132
- Topological Polar Surface Area: 38.9
Experimental Properties
- Density: 1.1±0.1 g/cm3
- Boiling Point: 329.1±30.0 °C at 760 mmHg
- Flash Point: 179.1±11.8 °C
- Vapor Pressure: 0.0±0.7 mmHg at 25°C
2-Cyclobutylpyridin-4-amine Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
2-Cyclobutylpyridin-4-amine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1512127-250mg |
2-Cyclobutylpyridin-4-amine |
1159818-59-3 | 98% | 250mg |
￥4132.00 | 2024-08-09 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1512127-1g |
2-Cyclobutylpyridin-4-amine |
1159818-59-3 | 98% | 1g |
￥12073.00 | 2024-08-09 | |
| A2B Chem LLC | AE32059-100mg |
2-cyclobutylpyridin-4-aMine |
1159818-59-3 | > 95% | 100mg |
$924.00 | 2024-04-20 | |
| A2B Chem LLC | AE32059-250mg |
2-cyclobutylpyridin-4-aMine |
1159818-59-3 | > 95% | 250mg |
$1757.00 | 2024-04-20 | |
| A2B Chem LLC | AE32059-1g |
2-cyclobutylpyridin-4-aMine |
1159818-59-3 | > 95% | 1g |
$3357.00 | 2024-04-20 | |
| A2B Chem LLC | AE32059-5g |
2-cyclobutylpyridin-4-aMine |
1159818-59-3 | > 95% | 5g |
$8424.00 | 2024-04-20 | |
| TRC | C406500-25mg |
2-Cyclobutylpyridin-4-amine |
1159818-59-3 | 25mg |
$173.00 | 2023-05-18 | ||
| TRC | C406500-100mg |
2-Cyclobutylpyridin-4-amine |
1159818-59-3 | 100mg |
$603.00 | 2023-05-18 | ||
| TRC | C406500-250mg |
2-Cyclobutylpyridin-4-amine |
1159818-59-3 | 250mg |
$ 1200.00 | 2023-09-08 |
2-Cyclobutylpyridin-4-amine Related Literature
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Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
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Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
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J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
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Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
Additional information on 2-Cyclobutylpyridin-4-amine
Recent Advances in the Study of 2-Cyclobutylpyridin-4-amine (CAS: 1159818-59-3) in Chemical Biology and Pharmaceutical Research
The compound 2-Cyclobutylpyridin-4-amine (CAS: 1159818-59-3) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential applications in drug discovery and development. This research briefing aims to provide an overview of the latest findings related to this compound, focusing on its synthesis, biological activity, and therapeutic potential. The information presented herein is derived from recent peer-reviewed publications, patent filings, and industry reports, ensuring the accuracy and relevance of the data.
Recent studies have highlighted the unique structural features of 2-Cyclobutylpyridin-4-amine, which make it a promising scaffold for the design of novel bioactive molecules. The cyclobutyl ring, in particular, has been shown to confer enhanced metabolic stability and improved binding affinity to target proteins. Researchers have successfully synthesized this compound using advanced catalytic methods, such as palladium-catalyzed cross-coupling reactions, which offer high yields and excellent stereoselectivity. These synthetic approaches have paved the way for the development of derivatives with optimized pharmacological properties.
In terms of biological activity, 2-Cyclobutylpyridin-4-amine has demonstrated notable efficacy in modulating key signaling pathways implicated in various diseases. For instance, recent in vitro and in vivo studies have revealed its potential as an inhibitor of protein kinases involved in cancer progression. Additionally, its ability to interact with G-protein-coupled receptors (GPCRs) has sparked interest in its application for neurological disorders. The compound's favorable pharmacokinetic profile, including good oral bioavailability and low toxicity, further underscores its therapeutic potential.
One of the most exciting developments in this area is the incorporation of 2-Cyclobutylpyridin-4-amine into drug candidates currently undergoing preclinical and clinical evaluation. Several pharmaceutical companies have filed patents covering its use in combination therapies, particularly for oncology and inflammatory diseases. These advancements highlight the compound's versatility and its potential to address unmet medical needs. However, challenges such as off-target effects and drug resistance mechanisms remain areas of active investigation.
In conclusion, 2-Cyclobutylpyridin-4-amine (CAS: 1159818-59-3) represents a valuable chemical entity with broad applications in drug discovery. Its unique structural and pharmacological properties make it a promising candidate for the development of next-generation therapeutics. Ongoing research efforts are expected to further elucidate its mechanisms of action and expand its utility across diverse therapeutic areas. This briefing underscores the importance of continued investment in the study of this compound to unlock its full potential in the pharmaceutical industry.
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