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• 3. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

N-(4-Pentanoylphenyl)acetamide (CAS 33228-40-9): A Comprehensive Technical Profile

N-(4-Pentanoylphenyl)acetamide (CAS 33228-40-9), also known as 4'-Acetamidovalerophenone, is an important organic compound with growing interest in pharmaceutical and chemical research. This white to off-white crystalline powder belongs to the class of aromatic amides and ketones, featuring a molecular formula of C13H17NO2 and molecular weight of 219.28 g/mol.

The compound's structure combines both acetamide and pentanoyl functional groups attached to a benzene ring, creating unique physicochemical properties. Recent studies highlight its potential as a key intermediate in organic synthesis, particularly for developing novel drug candidates. Researchers are particularly interested in its hydrogen bonding capacity and aromatic electron density, which make it valuable for molecular design.

In analytical chemistry, N-(4-Pentanoylphenyl)acetamide 33228-40-9 shows excellent chromatographic behavior, with typical retention times between 8-12 minutes in reverse-phase HPLC using C18 columns with methanol/water mobile phases. Its UV absorption maxima occur at 248 nm and 290 nm, making it easily detectable by standard UV-Vis spectrophotometers. These properties answer common search queries about "how to analyze N-(4-Pentanoylphenyl)acetamide" and "HPLC methods for 4'-Acetamidovalerophenone".

The thermal stability of CAS 33228-40-9 has been extensively studied, showing decomposition temperatures above 180°C. Differential scanning calorimetry reveals a sharp melting point at 98-102°C, which is frequently asked about in search engines. Its solubility profile includes good dissolution in polar organic solvents like methanol, ethanol, and acetonitrile, but limited water solubility (0.5 mg/mL at 25°C).

Current research trends focus on the compound's potential applications in medicinal chemistry. The N-(4-Pentanoylphenyl)acetamide structure serves as a valuable scaffold for designing enzyme inhibitors and receptor modulators. Recent publications (2023-2024) explore its derivatives as potential candidates for metabolic disorder treatments, addressing the popular search topic "new drug development intermediates".

From a synthetic chemistry perspective, 4'-Acetamidovalerophenone synthesis typically involves Friedel-Crafts acylation followed by amidation reactions. Process optimization studies have improved yields to 75-85% using greener catalysts, responding to industry demands for "sustainable chemical synthesis methods". The compound's purity can exceed 99% after recrystallization from ethanol/water mixtures.

In material science applications, N-(4-Pentanoylphenyl)acetamide 33228-40-9 has shown promise as a building block for advanced organic materials. Its ability to form stable hydrogen-bonded networks makes it interesting for crystal engineering applications, particularly in designing non-linear optical materials. This addresses growing interest in "organic electronic materials" and "molecular crystals for photonics".

Safety assessments indicate that CAS 33228-40-9 requires standard laboratory precautions. While not classified as hazardous under current regulations, proper personal protective equipment (gloves, goggles) is recommended when handling. The compound shows good stability under normal storage conditions (room temperature, protected from moisture), with shelf lives exceeding 24 months when properly stored.

The global market for N-(4-Pentanoylphenyl)acetamide has seen steady growth (CAGR 6.2% from 2020-2024), driven by increasing R&D investment in specialty chemicals. Major suppliers typically offer quantities ranging from gram to kilogram scales, with custom synthesis options available. Pricing trends show moderate fluctuations based on raw material availability, making "N-(4-Pentanoylphenyl)acetamide price analysis" a common search term among procurement specialists.

Quality control protocols for 4'-Acetamidovalerophenone typically include HPLC purity testing, residual solvent analysis, and identity confirmation by FTIR and NMR spectroscopy. Batch-to-batch consistency is crucial for pharmaceutical applications, explaining why "CAS 33228-40-9 specification sheets" rank highly in search analytics. Leading manufacturers provide comprehensive certificates of analysis with each shipment.

Future research directions for N-(4-Pentanoylphenyl)acetamide include exploring its biological activity profile and developing more efficient synthetic routes. Computational chemistry studies predict interesting interactions with various biological targets, particularly in neurological pathways. These developments align with current interests in "AI-assisted drug discovery" and "computational molecular design", making this compound relevant to cutting-edge research.

Environmental fate studies show that CAS 33228-40-9 undergoes moderate biodegradation in soil (50% in 60 days) and has low bioaccumulation potential. Waste handling recommendations include incineration with proper air pollution controls or approved chemical waste treatment facilities. These environmental characteristics respond to increasing searches for "green chemistry solutions" and "sustainable chemical practices".

For researchers working with N-(4-Pentanoylphenyl)acetamide, proper analytical reference standards are essential. Certified reference materials are available from major chemical suppliers, typically with purity ≥98.5%. This addresses frequent queries about "where to buy N-(4-Pentanoylphenyl)acetamide reference standards". Cross-validation between different analytical techniques (HPLC, GC, LC-MS) is recommended for critical applications.

In summary, N-(4-Pentanoylphenyl)acetamide (CAS 33228-40-9) represents a versatile chemical building block with growing importance across multiple scientific disciplines. Its well-characterized properties, synthetic accessibility, and potential applications make it a compound of continuing interest to researchers and industry professionals alike.

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