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• Solvents and Organic Chemicals Organic Compounds Organosulfur compounds Thioethers Aryl thioethers

Professional Introduction to 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile (CAS No. 33097-13-1)

4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile, with the chemical formula C?H?Cl?N?S, is a versatile heterocyclic compound that has garnered significant attention in the field of pharmaceutical and agrochemical research. This compound serves as a crucial intermediate in the synthesis of various biologically active molecules, particularly in the development of novel therapeutic agents. Its unique structural features, including the presence of chlorine and methylsulfanyl substituents, make it a valuable building block for further functionalization and derivatization.

The CAS number 33097-13-1 identifies this compound as a specific chemical entity, ensuring consistency and accuracy in its identification and use across different scientific disciplines. The molecular structure of 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile consists of a pyrimidine core substituted with two chlorine atoms at the 4- and 6-positions, a methylsulfanyl group at the 2-position, and a nitrile group at the 5-position. This arrangement imparts distinct reactivity patterns that are exploited in synthetic chemistry.

In recent years, 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile has been extensively studied for its potential applications in medicinal chemistry. One of the most notable areas of research involves its use as a precursor in the synthesis of antiviral and anticancer agents. The pyrimidine scaffold is a common motif in many pharmacologically active compounds, and modifications to this core structure can lead to novel drug candidates with improved efficacy and reduced side effects.

Recent studies have highlighted the utility of 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile in the development of inhibitors targeting specific enzymatic pathways involved in disease progression. For instance, researchers have explored its derivatives as potential inhibitors of kinases, which are enzymes that play a critical role in cell signaling and are often dysregulated in cancer cells. The chlorine and methylsulfanyl groups provide handles for further chemical modification, allowing chemists to fine-tune the properties of these derivatives for optimal biological activity.

The agrochemical industry has also recognized the significance of 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile as a key intermediate in the synthesis of crop protection agents. Pyrimidine-based compounds are widely used in pesticides due to their ability to interact with biological targets in pests, leading to their control or eradication. The structural features of this compound make it an excellent candidate for developing new generations of agrochemicals that are more effective and environmentally sustainable.

From a synthetic chemistry perspective, 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile offers a rich platform for exploring new reaction pathways and methodologies. The presence of multiple reactive sites allows for diverse functionalizations, including nucleophilic substitutions, metal-catalyzed cross-coupling reactions, and cyclizations. These reactions can be tailored to produce complex molecular architectures that mimic natural products or exhibit novel biological activities.

The pharmaceutical industry has leveraged the versatility of 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile to develop several promising drug candidates. For example, researchers have synthesized derivatives of this compound that exhibit inhibitory effects on enzymes associated with inflammatory diseases. By modifying the substituents on the pyrimidine ring, scientists have been able to optimize potency and selectivity, paving the way for new therapeutic strategies.

Advances in computational chemistry have further enhanced the understanding of how 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile interacts with biological targets. Molecular modeling studies have provided insights into binding affinities and mechanisms of action, enabling rational drug design approaches. These computational tools are invaluable for predicting the efficacy of new derivatives before they are synthesized in the lab.

The synthesis of 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile itself is an intricate process that requires careful optimization to ensure high yields and purity. Industrial-scale production often involves multi-step reactions starting from readily available precursors. Advances in green chemistry principles have also influenced synthetic routes towards more sustainable practices, minimizing waste and reducing hazardous byproducts.

Future research directions for 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile may focus on expanding its applications beyond pharmaceuticals and agrochemicals into other areas such as materials science. The unique electronic properties of pyrimidine-based compounds make them attractive candidates for organic electronics applications like light-emitting diodes (OLEDs) and photovoltaic cells.

In conclusion,4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile (CAS No. 33097-13-1) is a multifaceted compound with broad utility across multiple scientific disciplines. Its role as an intermediate in drug discovery and agrochemical development underscores its importance in modern chemistry research. As scientific understanding continues to evolve,4,6,-dichloro-, 2-,((methyl-sulfanyl))-pyrimidinylidenecarbonitrile will undoubtedly remain at forefront innovation efforts aimed creating safer more effective solutions improve human health protect crops sustainably.

• 13480-96-1(Pyrimidine,4-chloro-2-(ethylthio)-5-methyl-)
• 1208170-17-5(4-Chloro-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile)
• 771571-91-6(5-Pyrimidinemethanamine,4,6-dichloro-2-(methylthio)-)
• 33097-14-2(5-Pyrimidinecarbonitrile, 4-amino-6-chloro-2-(methylthio)-)
• 33089-15-5(4-chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile)
• 61044-96-0(4-chloro-5-methyl-2-(methylsulfanyl)pyrimidine)
• 317830-03-8(4-Chloro-2-(ethylthio)pyrimidine-5-carbonitrile)
• 1263314-13-1(4,6-dichloro-5-ethyl-2-(methylsulfanyl)pyrimidine)
• 1044145-59-6([4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol)
• 5305-45-3(4,6-Dichloropyrimidine-5-carbonitrile)