Cas no 1044145-59-6 ([4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol)

[4-Chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol is a versatile pyrimidine derivative with significant utility in pharmaceutical and agrochemical synthesis. Its key structural features—a reactive chloro group at the 4-position and a methylsulfanyl moiety at the 2-position—enable selective functionalization, making it a valuable intermediate for heterocyclic modifications. The hydroxymethyl group at the 5-position further enhances its reactivity, allowing for derivatization into esters, ethers, or other functionalized compounds. This compound exhibits high purity and stability under standard storage conditions, ensuring consistent performance in cross-coupling reactions, nucleophilic substitutions, and other transformations. Its well-defined reactivity profile makes it particularly useful for constructing complex molecular architectures in medicinal chemistry and crop protection research.

[4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol structure

1044145-59-6 structure

Product Name:[4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol

CAS No:1044145-59-6

MF:C₆H₇ClN₂OS

MW:190.650578737259

MDL:MFCD11858523

CID:1024243

PubChem ID:59419388

Update Time:2025-10-29

[4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol Chemical and Physical Properties

Names and Identifiers

- (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol
- (4-Chloro-2-methylsulfanyl-pyrimidin-5-yl)methanol
- [4-Chloro-2-(methylthio)pyrimidin-5-yl]methanol
- 4-Chloro-2-(methylthio)-5-pyrimidinemethanol
- (4-CHLORO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL
- [4-Chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol
- ADJUHOQFENGHSW-UHFFFAOYSA-N
- 0994AA
- PB13454
- (4-chloro-2-methylsulfanylpyrimidin-5-yl)methanol
- 4-Chloro-5-(hydr
- 1044145-59-6
- SCHEMBL1355444
- 4-Chloro-5-(hydroxymethyl)-2-(methylsulfanyl)pyrimidine
- SY023012
- DTXSID10731939
- 4-Chloro-2-(methylthio)pyrimidine-5-methanol
- CS-0052982
- 4-Chloro-5-(hydroxymethyl)-2-(methylthio)pyrimidine
- Z1255439569
- EN300-256233
- P11247
- AMY34495
- AS-50847
- MFCD11858523
- AKOS016004510
- DB-059134
- [4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol
- MDL： MFCD11858523
- Inchi： 1S/C6H7ClN2OS/c1-11-6-8-2-4(3-10)5(7)9-6/h2,10H,3H2,1H3
- InChI Key： ADJUHOQFENGHSW-UHFFFAOYSA-N
- SMILES： ClC1C(=CN=C(N=1)SC)CO

Computed Properties

Exact Mass: 189.9967617g/mol
Monoisotopic Mass: 189.9967617g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 11
Rotatable Bond Count: 2
Complexity: 127
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 71.3
XLogP3: 1.1

Experimental Properties

Density: 1.45
Boiling Point: 339.6℃ at 760 mmHg
PSA: 71.31000
LogP: 1.34420

[4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	C906764-5g	(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol	1044145-59-6	95%	5g	2,658.60	2021-05-17
CHENG DOU FEI BO YI YAO Technology Co., Ltd.	FB06252-5g	[4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol	1044145-59-6	95%	5g	$975	2023-09-07
Matrix Scientific	084242-500mg	(4-Chloro-2-methylsulfanyl-pyrimidin-5-yl)methanol, 97%	1044145-59-6	97%	500mg	$300.00	2023-09-06
Matrix Scientific	084242-1g	(4-Chloro-2-methylsulfanyl-pyrimidin-5-yl)methanol, 97%	1044145-59-6	97%	1g	$535.00	2023-09-06
Fluorochem	224906-1g	4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol	1044145-59-6	95%	1g	￡167.00	2022-02-28
Fluorochem	224906-5g	4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol	1044145-59-6	95%	5g	￡499.00	2022-02-28
Fluorochem	224906-25g	4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol	1044145-59-6	95%	25g	￡2193.00	2022-02-28
ChemScence	CS-0052982-100mg	(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol	1044145-59-6	99.25%	100mg	$58.0	2022-04-28
ChemScence	CS-0052982-250mg	(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol	1044145-59-6	99.25%	250mg	$84.0	2022-04-28
ChemScence	CS-0052982-1g	(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol	1044145-59-6	99.25%	1G	$127.0	2022-04-28

[4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:1044145-59-6)(4-CHLORO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL

Order Number:LE7963

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 11:58

Price ($):discuss personally

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Related Categories

Solvents and Organic Chemicals Organic Compounds Organosulfur compounds Thioethers Aryl thioethers

Additional information on [4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol

Comprehensive Overview of [4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol (CAS No. 1044145-59-6)

[4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol (CAS No. 1044145-59-6) is a specialized pyrimidine derivative with significant applications in pharmaceutical and agrochemical research. This compound, characterized by its chloro and methylsulfanyl functional groups, serves as a versatile intermediate in the synthesis of bioactive molecules. Its unique structure, featuring a hydroxymethyl moiety at the 5-position of the pyrimidine ring, enables diverse chemical modifications, making it valuable for drug discovery and material science.

The growing interest in pyrimidine-based compounds stems from their broad biological activities, including antimicrobial, antiviral, and anticancer properties. Researchers frequently search for "pyrimidine derivatives in drug development" or "CAS 1044145-59-6 applications," reflecting the compound's relevance in modern medicinal chemistry. Its chloro-substituted pyrimidine core is particularly noteworthy, as halogenated heterocycles often exhibit enhanced binding affinity to biological targets.

In agrochemical applications, [4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol has garnered attention for its potential role in developing novel pesticides and herbicides. Searches like "pyrimidine herbicides 2024" or "methylsulfanyl pyrimidine uses" highlight industry trends toward eco-friendly crop protection agents. The compound's methylsulfanyl group contributes to improved lipophilicity, a critical factor in formulation design.

Synthetic accessibility is another key advantage of this compound. Laboratory protocols often focus on "efficient synthesis of 5-hydroxymethyl pyrimidines" or "1044145-59-6 preparation method," as the methanol substituent allows straightforward derivatization. Recent publications describe its use in constructing kinase inhibitors and enzyme modulators, aligning with the pharmaceutical industry's emphasis on targeted therapies.

From a regulatory perspective, CAS 1044145-59-6 complies with international chemical control frameworks when used appropriately. Quality control parameters such as "HPLC purity of pyrimidine intermediates" and "spectroscopic characterization of 1044145-59-6" are frequently discussed in analytical chemistry forums, underscoring the importance of rigorous standardization in research applications.

The compound's stability profile makes it suitable for diverse reaction conditions, addressing common search queries like "storage conditions for chloro-pyrimidinemethanol." Its compatibility with modern green chemistry principles—evidenced by searches for "solvent-free pyrimidine modifications"—positions it as a sustainable choice for industrial-scale applications.

Emerging research directions include the compound's potential in material science, particularly in designing organic electronic components. The conjugated π-system of the pyrimidine ring, combined with the hydroxymethyl handle, enables integration into functional polymers—a topic gaining traction in searches for "heterocyclic building blocks for OLEDs."

For procurement specialists, technical specifications such as "1044145-59-6 supplier analysis" and "bulk pricing for research chemicals" reflect practical considerations. The compound's commercial availability in various purity grades (98-99%) facilitates both small-scale research and pilot plant evaluations.

In summary, [4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol represents a multifaceted chemical tool with expanding applications across life sciences and advanced materials. Its structural features answer contemporary research needs while maintaining compliance with evolving regulatory standards—a balance that sustains its growing prominence in scientific literature and industrial practice.

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