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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Phenylpiperazines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines Phenylpiperazines

Comprehensive Overview of 1-Boc-4-(3-Bromophenyl)piperazine (CAS No. 327030-39-7): Properties, Applications, and Industry Insights

1-Boc-4-(3-bromophenyl)piperazine (CAS No. 327030-39-7) is a highly versatile organic compound widely utilized in pharmaceutical research, medicinal chemistry, and drug discovery. This Boc-protected piperazine derivative features a 3-bromophenyl substituent, making it a critical intermediate for synthesizing bioactive molecules. Its molecular formula, C₁₅H₂₁BrN₂O₂, and molecular weight of 341.25 g/mol underscore its relevance in structure-activity relationship (SAR) studies and high-throughput screening.

The growing demand for piperazine-based scaffolds in CNS drug development has propelled interest in 1-Boc-4-(3-bromophenyl)piperazine. Researchers frequently search for "Boc deprotection conditions" or "piperazine derivatives in drug design," reflecting its role in optimizing blood-brain barrier permeability. Recent trends also highlight its potential in targeted protein degradation (PROTACs) and GPCR modulator synthesis, aligning with the rise of precision medicine.

From a synthetic perspective, 327030-39-7 serves as a key building block for heterocyclic compounds. Its bromine atom enables cross-coupling reactions (e.g., Suzuki-Miyaura), addressing frequent search queries like "palladium-catalyzed arylations." The Boc group offers orthogonal protection, a feature often discussed in forums on "amine protection strategies." These attributes make it indispensable for constructing multi-target-directed ligands (MTDLs) in neurodegenerative disease research.

Quality control of 1-Boc-4-(3-bromophenyl)piperazine involves rigorous HPLC purity analysis and NMR characterization, topics frequently queried alongside "CAS 327030-39-7 specifications." The compound’s stability under ambient storage conditions (typically 2-8°C) and solubility in polar aprotic solvents (DMSO, DMF) are practical considerations for laboratories. Notably, its applications extend to PET tracer development, where the 3-bromophenyl moiety facilitates isotope labeling.

Emerging discussions in green chemistry have explored solvent-free Boc deprotection methods for derivatives like 327030-39-7, responding to searches for "eco-friendly peptide synthesis." Additionally, its relevance in fragment-based drug discovery (FBDD) aligns with industry shifts toward low-molecular-weight pharmacophores. Patent analyses reveal its use in kinase inhibitor pipelines, particularly for oncological targets.

In conclusion, 1-Boc-4-(3-bromophenyl)piperazine (CAS No. 327030-39-7) remains a cornerstone in modern chemical biology. Its dual functionality as a protecting group carrier and aryl halide precursor addresses diverse research needs—from combinatorial chemistry to bioconjugation. As the pharmaceutical industry prioritizes small-molecule therapeutics, this compound’s strategic importance continues to grow, evidenced by rising scholarly citations and commercial procurement inquiries.

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