Cas no 32634-66-5 ((-)-Di-p-toluoyl-L-tartaric Acid)
(-)-Di-p-toluoyl-L-tartaric Acid Chemical and Physical Properties
Names and Identifiers
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- (2R,3R)-2,3-Bis((4-methylbenzoyl)oxy)succinic acid
- (-)-Di-p-toluoyl-(L)-tartaric acid monohydrate anhydrous
- (-)-DI-O,O'-p-TOLUYL-L-TARTARIC ACID
- Di-p-Toluoyl-D-Tartaric acid
- Di-P-toluoyl-L-tartaric acid
- (-)-Di-p-toluoyl-L-tartaric Acid
- (-)-O,O’-Di-p-toluoyl-L-tartaric Acid
- Di-p-toluoyl-L-tartaric acid monohydrate
- O,O'-Di-p-toluoyl-L-tartaric Acid
- (-)-di-O,O-p-toluoyl tartaric acid
- (-)-O,O`-Di-p-toluoyl-L-tartaric
- (+ )-Di-1,4-toluoyl-Ltartaricacid
- Di-4-Toluoyl-L-tartaric acid
- di-O,O'-p-toluyl-D-tartaric acid
- Di-p-Toluoy-L-Tartaric Acid
- DTTA
- Tartaric acid,di-p-toluate
- L-(-)-DTTA
- (-)-Di-1,4-O-toluoyl-L-tartaric acid
- L-(-)-Di-1,4-O-tolyltartaric acid
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- MDL： MFCD00064440
- Inchi： 1S/C20H18O8/c1-11-3-7-13(8-4-11)19(25)27-15(17(21)22)16(18(23)24)28-20(26)14-9-5-12(2)6-10-14/h3-10,15-16H,1-2H3,(H,21,22)(H,23,24)/t15-,16-/m1/s1
- InChI Key： CMIBUZBMZCBCAT-HZPDHXFCSA-N
- SMILES： O(C(C1C=CC(C)=CC=1)=O)[C@@H](C(=O)O)[C@H](C(=O)O)OC(C1C=CC(C)=CC=1)=O
- BRN： 2022481
Computed Properties
- Exact Mass: 404.11100
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 8
- Heavy Atom Count: 28
- Rotatable Bond Count: 9
- Complexity: 522
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: -2
- XLogP3: 4.6
- Topological Polar Surface Area: 133
Experimental Properties
- Color/Form: White to yellow crystalline powder
- Density: 1.3084 (rough estimate)
- Melting Point: 169-171?°C (lit.)
- Boiling Point: 626.5℃ at 760 mmHg
- Flash Point: 223.2℃
- Refractive Index: -139 ° (C=1, EtOH)
- Water Partition Coefficient: dissolution
- PSA: 136.43000
- LogP: 2.15930
- Solubility: Insoluble in water
- Specific Rotation: -142 o (c=10, EtOH)
- Optical Activity: [α]20/D ?138°, c =?1 in ethanol
- Sensitiveness: Easily absorb moisture
(-)-Di-p-toluoyl-L-tartaric Acid Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H315-H319
- Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： S24/25
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Hazardous Material Identification：
- Safety Term：S24/25
- Risk Phrases：R36/37/38
- TSCA：T
- Storage Condition：Store at room temperature
(-)-Di-p-toluoyl-L-tartaric Acid Customs Data
- HS CODE：2918130000
- Customs Data：
China Customs Code:
2918990090Overview:
2918990090. Other additional oxy carboxylic acids(Including anhydrides\Acyl halide\Peroxides, peroxyacids and derivatives of this tax number). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
(-)-Di-p-toluoyl-L-tartaric Acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D1387-25g |
(-)-Di-p-toluoyl-L-tartaric Acid |
32634-66-5 | 98.0%(LC&T) | 25g |
￥190.0 | 2022-09-28 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D1387-250g |
(-)-Di-p-toluoyl-L-tartaric Acid |
32634-66-5 | 98.0%(LC&T) | 250g |
￥590.0 | 2022-09-28 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D194A-25g |
(-)-Di-p-toluoyl-L-tartaric Acid |
32634-66-5 | 98% | 25g |
￥44.0 | 2022-09-28 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D194A-100g |
(-)-Di-p-toluoyl-L-tartaric Acid |
32634-66-5 | 98% | 100g |
￥75.0 | 2022-09-28 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D194A-500g |
(-)-Di-p-toluoyl-L-tartaric Acid |
32634-66-5 | 98% | 500g |
￥274.0 | 2022-09-28 | |
| Chemenu | CM102474-1000g |
2,3-bis(4-methylbenzoyloxy)succinic acid |
32634-66-5 | 95%+ | 1000g |
$40 | 2021-06-17 | |
| Alichem | A019095335-500g |
(2R,3R)-2,3-Bis((4-methylbenzoyl)oxy)succinic acid |
32634-66-5 | 98% | 500g |
$201.96 | 2023-09-02 | |
| Alichem | A019095335-1000g |
(2R,3R)-2,3-Bis((4-methylbenzoyl)oxy)succinic acid |
32634-66-5 | 98% | 1000g |
$255.00 | 2023-09-02 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C1808569343- 25g |
(-)-Di-p-toluoyl-L-tartaric Acid |
32634-66-5 | 99%（HPLC） | 25g |
￥ 30.6 | 2021-05-18 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C1808569335- 100g |
(-)-Di-p-toluoyl-L-tartaric Acid |
32634-66-5 | 99%（HPLC） | 100g |
￥ 69.4 | 2021-05-18 |
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(-)-Di-p-toluoyl-L-tartaric Acid Related Literature
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1. 1-Phenethylisoquinoline alkaloids. Part I. Structure and synthesis of (–)-melanthioidine, a bisphenethylisoquinoline alkaloidA. R. Battersby,R. B. Herbert,Lucy Mo,F. ?antavy J. Chem. Soc. C 1967 1739
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2. Index of subjects, 1896
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5. Index of subjects, 1899
Additional information on (-)-Di-p-toluoyl-L-tartaric Acid
Introduction to 32634-66-5 and (-)-Di-p-toluoyl-L-tartaric Acid
(-)-Di-p-toluoyl-L-tartaric Acid (CAS No. 32634-66-5) is a significant compound in the field of chemo-biopharmaceuticals, widely recognized for its unique chemical properties and potential applications in medicinal chemistry. This compound, characterized by its di-p-toluoyl derivative of L-tartaric acid, has garnered considerable attention due to its structural complexity and versatile functionalities.
The molecular structure of (-)-Di-p-toluoyl-L-tartaric Acid consists of a tartaric acid backbone, which is a well-known alpha-hydroxy acid, modified with two p-toluoyl groups. This modification enhances the compound's solubility and stability, making it an attractive candidate for various pharmaceutical applications. The tartaric acid moiety is particularly interesting because it exhibits both chiral and acidic properties, which can be exploited in the design of enantiomerically pure drugs.
In recent years, there has been a growing interest in the development of chiral auxiliaries and catalysts for asymmetric synthesis. (-)-Di-p-toluoyl-L-tartaric Acid has been explored as a potential chiral auxiliary in organic synthesis due to its ability to induce enantioselective reactions. Its application in asymmetric hydrogenation and epoxidation reactions has shown promising results, contributing to the efficient synthesis of optically active compounds.
The compound's utility extends beyond synthetic chemistry into the realm of drug discovery. The p-toluoyl groups introduce lipophilicity, which can enhance the bioavailability of associated molecules. This feature makes (-)-Di-p-toluoyl-L-tartaric Acid a valuable scaffold for designing novel therapeutic agents. For instance, its structural motif has been incorporated into potential inhibitors of enzymes involved in metabolic disorders.
Recent studies have highlighted the role of (-)-Di-p-toluoyl-L-tartaric Acid in modulating biological pathways. Researchers have observed that derivatives of this compound exhibit inhibitory effects on certain kinases and proteases, which are implicated in various diseases, including cancer and inflammatory conditions. The precise stereochemistry of the tartaric acid moiety appears to be crucial for these biological activities, underscoring the importance of enantiopure compounds in drug development.
The synthesis of (-)-Di-p-toluoyl-L-tartaric Acid involves multi-step organic reactions, including esterification and chiral resolution processes. Advances in synthetic methodologies have enabled more efficient and scalable production methods, making this compound more accessible for research and industrial applications. The use of green chemistry principles has also been explored to minimize waste and improve sustainability in its synthesis.
In conclusion, (-)-Di-p-toluoyl-L-tartaric Acid (CAS No. 32634-66-5) is a multifaceted compound with significant potential in pharmaceutical research and development. Its unique structural features and functional properties make it a valuable tool for synthetic chemists and medicinal chemists alike. As research continues to uncover new applications for this compound, its importance in the chemo-biopharmaceutical field is likely to grow further.
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