• 1. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 2. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 3. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 4. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 5. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines N-alkylpiperazines

2-(4-Propylpiperazin-1-yl)ethanol (CAS No. 3221-17-8): A Comprehensive Overview

2-(4-Propylpiperazin-1-yl)ethanol, also known by its CAS registry number 3221-17-8, is a chemical compound that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound is a derivative of piperazine, a six-membered ring containing two nitrogen atoms, and is characterized by its unique structure and versatile applications. In recent years, advancements in synthetic methodologies and its potential therapeutic applications have made 2-(4-propylpiperazin-1-yl)ethanol a focal point for researchers worldwide.

The molecular structure of 2-(4-propylpiperazin-1-yl)ethanol consists of a piperazine ring substituted with a propyl group at the 4-position and an ethanol group at the 1-position. This arrangement imparts the compound with distinct physicochemical properties, including moderate solubility in water and high stability under standard conditions. The compound's structure also facilitates its use in various chemical reactions, such as nucleophilic substitutions and condensations, making it a valuable intermediate in organic synthesis.

Recent studies have explored the potential of 2-(4-propylpiperazin-1-yl)ethanol in drug discovery. Its piperazine backbone is known to exhibit bioactivity, particularly in interactions with GABA receptors, which are critical targets for antiepileptic and anxiolytic agents. Researchers have reported that derivatives of this compound demonstrate promising activity in preclinical models of epilepsy and anxiety, suggesting its potential as a lead compound for therapeutic development.

In addition to its pharmacological applications, 2-(4-propylpiperazin-1-yl)ethanol has found utility in the synthesis of advanced materials. Its ability to form stable complexes with metal ions has led to its use in coordination chemistry and the development of metalloorganic frameworks (MOFs). Recent breakthroughs in this area have highlighted its role in enhancing the catalytic efficiency of MOFs, which are widely used in gas storage, separation, and catalysis.

The synthesis of 2-(4-propylpiperazin-1-yl)ethanol has also been optimized through green chemistry approaches. Traditional methods often involved multi-step reactions with low yields and high environmental impact. However, recent advancements have introduced more efficient protocols, such as one-pot synthesis using microwave-assisted techniques. These methods not only improve yield but also reduce reaction time and energy consumption, aligning with sustainable chemical practices.

From an analytical standpoint, modern spectroscopic techniques have provided deeper insights into the structural properties of 2-(4-propylpiperazin-1-yl)ethanol. High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) spectroscopy have been instrumental in confirming its molecular formula (C9H19N2O) and elucidating its stereochemistry. These findings are crucial for ensuring the accuracy of synthetic procedures and maintaining quality control in industrial production.

Looking ahead, the future of 2-(4-propylpiperazin-1-yl)ethanol appears promising as researchers continue to uncover its diverse applications. Its role as a building block in medicinal chemistry, coupled with its potential in materials science, positions it as a key compound for interdisciplinary research. As technological advancements continue to refine synthetic methods and expand application horizons, 2-(4-propylpiperazin-1-yethyl) will undoubtedly remain a subject of interest for both academia and industry.

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