• 1. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
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• 2. Dissociative dynamics of O2 on Ag(110)?
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• 3. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
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• 4. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
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• 5. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Acetanilides
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N-(3-Fluoro-2-methylphenyl)acetamide: A Comprehensive Overview

N-(3-Fluoro-2-methylphenyl)acetamide, also known by its CAS number 322-33-8, is a chemical compound that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound is characterized by its unique structure, which includes a fluoro-substituted aromatic ring and an acetamide functional group. The combination of these structural elements contributes to its diverse applications and intriguing chemical properties.

The fluorine atom at the 3-position of the phenyl ring plays a crucial role in modulating the electronic properties of the molecule. Fluorine's electronegativity introduces a slight electron-withdrawing effect, which can influence the compound's reactivity and stability. This feature makes N-(3-Fluoro-2-methylphenyl)acetamide a valuable substrate for various chemical transformations, particularly in the synthesis of bioactive molecules.

Recent studies have highlighted the potential of N-(3-Fluoro-2-methylphenyl)acetamide as a precursor in drug discovery. Researchers have explored its ability to act as a building block for constructing complex heterocyclic compounds, which are often associated with therapeutic activity. For instance, its use in the synthesis of antidepressant agents has shown promising results, suggesting its role in modulating neurotransmitter systems.

In addition to its pharmacological applications, N-(3-Fluoro-2-methylphenyl)acetamide has been investigated for its environmental fate and toxicity profile. Understanding its behavior in aquatic systems is crucial for assessing its potential impact on ecosystems. Studies have demonstrated that the compound exhibits moderate biodegradability under aerobic conditions, which is an important consideration for industrial waste management.

The synthesis of N-(3-Fluoro-2-methylphenyl)acetamide typically involves a multi-step process, starting with the preparation of the corresponding aniline derivative. The introduction of the fluoro group at the 3-position is often achieved through nucleophilic aromatic substitution or electrophilic fluorination techniques. Subsequent acetylation yields the final acetamide product, which can then be subjected to further modifications to explore its reactivity and biological activity.

One area of active research is the exploration of N-(3-Fluoro-2-methylphenyl)acetamide's role in enzyme inhibition. Scientists have reported that this compound exhibits inhibitory effects on certain proteases, making it a potential candidate for developing anti-inflammatory or antiviral therapies. These findings underscore the importance of continued research into its molecular interactions and pharmacokinetic properties.

Moreover, advancements in computational chemistry have enabled researchers to perform detailed molecular docking studies on N-(3-Fluoro-2-methylphenyl)acetamide. These studies provide insights into how the compound interacts with target proteins at the molecular level, paving the way for rational drug design strategies. Such approaches are expected to enhance our understanding of its therapeutic potential and guide future development efforts.

In conclusion, N-(3-Fluoro-2-methylphenyl)acetamide (CAS No. 322-33-8) is a versatile compound with a wide range of applications in chemistry and pharmacology. Its unique structure and functional groups make it an attractive candidate for both academic research and industrial applications. As ongoing studies continue to uncover new insights into its properties and uses, this compound is poised to play an increasingly important role in advancing scientific knowledge and therapeutic innovation.

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• 458-10-6(Acetamide,N-(3-fluoro-4-methylphenyl)-)
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• 366-49-4(N-(5-fluoro-2-methylphenyl)acetamide)
• 811810-61-4(N-(3-fluoro-2-methylphenyl)-2,2-dimethylpropanamide)
• 922711-46-4(Acetamide, N-[2-(chloromethyl)-5-fluorophenyl]-)