Cas no 32133-36-1 (3,4-Difluorophenylalanine)
3,4-Difluorophenylalanine Chemical and Physical Properties
Names and Identifiers
-
- 2-Amino-3-(3,4-difluorophenyl)propanoic acid
- Difluorophenylalanine4
- 3,4-Difluoro-DL-phenylalanine
- (S)-2-Amino-3-(3,4-difluorophenyl)propanoic acid
- DL-3,4-Difluorophenylalanine
- 3,4-difluorophenylalanine
- Alanine,3-(3,4-difluorophenyl)-, DL- (8CI)
- DL-Phenylalanine, 3,4-difluoro-
- 32133-36-1
- CHEMBL4595176
- FT-0658432
- 3,4-Difluoro-DL-phenylalanine, 97% (H-DL-Phe(3,4-diF)-OH)
- HY-79171
- AB08129
- A50334
- FT-0698094
- DTXSID50371797
- EN300-1827555
- A821164
- SCHEMBL44051
- FT-0653929
- A817577
- PS-6486
- AB02430
- AKOS032963163
- AC-11396
- 2-azanyl-3-[3,4-bis(fluoranyl)phenyl]propanoic acid
- Alanine, 3-(3,4-difluorophenyl)-, L- (8CI)
- AKOS016843599
- Difluorophenylalanine4; 3,4-Difluoro-DL-phenylalanine;DL-3,4-Difluorophenylalanine
- CS-0011211
- SCHEMBL18511382
- AKOS000189019
- FT-0614289
- L-3,4-DIFLUOROPHE
- A875699
- MFCD00061307
- 2-amino-3-(3,4-difluoro-phenyl)-propionic acid
- D-3,4-difluorophenylalanine
- SY065302
- SY254931
- MFCD01075125
- MFCD01631986
- 3,4-Difluorophenylalanine
-
- MDL： MFCD00061307
- Inchi： 1S/C9H9F2NO2/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8H,4,12H2,(H,13,14)
- InChI Key： PRAWYXDDKCVZTL-UHFFFAOYSA-N
- SMILES： FC1=C(C=CC(=C1)CC(C(=O)O)N)F
Computed Properties
- Exact Mass: 201.06017
- Monoisotopic Mass: 201.06
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 14
- Rotatable Bond Count: 3
- Complexity: 213
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
- Topological Polar Surface Area: 63.3A^2
Experimental Properties
- Color/Form: Not determined
- Density: 1.379
- Melting Point: 237-240°C
- Boiling Point: 311.9 ℃ at 760 mmHg
- Flash Point: 142.5°C
- Refractive Index: 1.536
- PSA: 63.32
- LogP: 1.61950
- Solubility: Not determined
3,4-Difluorophenylalanine Security Information
- Signal Word：Warning
- Hazard Statement： H315; H319; H335
- Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
- Hazard Category Code： R36/37/38: irritating to eyes, respiratory tract and skin
- Safety Instruction： S36: wear appropriate protective clothing.
-
Hazardous Material Identification：
- HazardClass：IRRITANT
- Storage Condition：Store at room temperature
3,4-Difluorophenylalanine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 004858-250mg |
dl-3,4-Difluorophenylalanine |
32133-36-1 | 97% | 250mg |
￡16.00 | 2022-03-01 | |
| Fluorochem | 004858-5g |
dl-3,4-Difluorophenylalanine |
32133-36-1 | 97% | 5g |
￡319.00 | 2022-03-01 | |
| Alichem | A019119214-5g |
2-Amino-3-(3,4-difluorophenyl)propanoic acid |
32133-36-1 | 97% | 5g |
$260.00 | 2023-09-02 | |
| Alichem | A019119214-10g |
2-Amino-3-(3,4-difluorophenyl)propanoic acid |
32133-36-1 | 97% | 10g |
$350.00 | 2023-09-02 | |
| Alichem | A019119214-25g |
2-Amino-3-(3,4-difluorophenyl)propanoic acid |
32133-36-1 | 97% | 25g |
$770.00 | 2023-09-02 | |
| Chemenu | CM303617-5g |
2-Amino-3-(3,4-difluorophenyl)propanoic acid |
32133-36-1 | 97% | 5g |
$234 | 2021-06-09 | |
| TRC | D452165-50mg |
3,4-Difluoro-DL-phenylalanine |
32133-36-1 | 50mg |
$ 50.00 | 2022-06-05 | ||
| TRC | D452165-100mg |
3,4-Difluoro-DL-phenylalanine |
32133-36-1 | 100mg |
$ 65.00 | 2022-06-05 | ||
| TRC | D452165-500mg |
3,4-Difluoro-DL-phenylalanine |
32133-36-1 | 500mg |
$ 135.00 | 2022-06-05 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | D857075-5g |
3,4-Difluoro-DL-phenylalanine |
32133-36-1 | 98% | 5g |
￥1,900.00 | 2022-01-14 |
3,4-Difluorophenylalanine Suppliers
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3,4-Difluorophenylalanine Related Literature
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Yan-Jiun Lee,M. J. Schmidt,Jeffery M. Tharp,Annemarie Weber,Amber L. Koenig,Hong Zheng,Jianmin Gao,Marcey L. Waters,Daniel Summerer,Wenshe R. Liu Chem. Commun. 2016 52 12606
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Susana M. Ramalhete,Jamie S. Foster,Hayley R. Green,Karol P. Nartowski,Margaux Heinrich,Peter C. Martin,Yaroslav Z. Khimyak,Gareth O. Lloyd Faraday Discuss. 2017 203 423
Additional information on 3,4-Difluorophenylalanine
Comprehensive Overview of 3,4-Difluorophenylalanine (CAS No. 32133-36-1): Properties, Applications, and Research Insights
3,4-Difluorophenylalanine (CAS No. 32133-36-1) is a fluorinated derivative of the amino acid phenylalanine, characterized by the substitution of hydrogen atoms with fluorine at the 3 and 4 positions of the phenyl ring. This modification enhances its biochemical stability and bioavailability, making it a valuable compound in pharmaceutical research, peptide synthesis, and material science. The presence of fluorine atoms significantly alters its electronic properties and metabolic resistance, which are critical for designing enzyme inhibitors and therapeutic agents.
In recent years, the demand for fluorinated amino acids like 3,4-Difluorophenylalanine has surged due to their role in drug discovery and precision medicine. Researchers are particularly interested in its potential to improve the pharmacokinetic profiles of peptide-based drugs, a topic frequently searched in AI-driven drug design platforms. Its ability to modulate protein-protein interactions and receptor binding aligns with current trends in targeted cancer therapies and neurodegenerative disease research.
The synthesis of 3,4-Difluorophenylalanine involves multi-step organic reactions, including fluorination and chiral resolution, to achieve high enantiomeric purity. This process is often optimized for green chemistry principles, addressing the growing emphasis on sustainable synthesis in the chemical industry. Analytical techniques such as HPLC, NMR, and mass spectrometry are employed to verify its structural integrity, a common query among quality control professionals.
Beyond pharmaceuticals, 3,4-Difluorophenylalanine is explored in agrochemicals for its potential to enhance pesticide efficacy and plant growth regulators. Its unique stereochemical properties also make it a candidate for advanced materials, such as liquid crystals and polymeric coatings. These applications resonate with searches related to innovative material science and bio-inspired engineering.
Safety and handling of 3,4-Difluorophenylalanine adhere to standard laboratory protocols, with no significant toxicity concerns reported under normal conditions. However, its storage stability and solubility in aqueous and organic solvents are frequently discussed in research forums and technical datasheets. This aligns with the broader interest in chemical safety databases and regulatory compliance.
In conclusion, 3,4-Difluorophenylalanine (CAS No. 32133-36-1) exemplifies the intersection of fluorine chemistry and life sciences, offering versatile solutions for modern challenges. Its relevance to high-impact research areas ensures continued interest from academia and industry, as reflected in search engine trends and scientific publications.
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