Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader?
Chemical Communications Pub Date: 2016-09-27 DOI: 10.1039/C6CC05959G
Abstract
Fluorophenylalanines bearing 2–5 fluorine atoms at the phenyl ring have been genetically encoded by amber codon. Replacement of F59, a phenylalanine residue that is directly involved in interactions with trimethylated K9 of histone H3, in the Mpp8 chromodomain recombinantly with fluorophenylalanines significantly impairs the binding to a K9-trimethylated H3 peptide.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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