• 1. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 2. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 3. Excitonic and vibrational coherence in artificial photosynthetic systems studied by negative-time ultrafast laser spectroscopy
  Dongjia Han,Bing Xue,Juan Du,Tomohiro Miyatake,Hitoshi Tamiaki,Xin Xing,Wei Yuan,Yanyan Li Phys. Chem. Chem. Phys., 2016,18, 24252-24260
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Imidazoles Substituted imidazoles

Recent Advances in the Application of 1H-Imidazole-1-carboxaldehyde (CAS: 3197-61-3) in Chemical Biology and Pharmaceutical Research

1H-Imidazole-1-carboxaldehyde (CAS: 3197-61-3) is a versatile chemical intermediate that has garnered significant attention in recent years due to its potential applications in chemical biology and pharmaceutical research. This heterocyclic aldehyde serves as a key building block for the synthesis of various biologically active compounds, including imidazole-based drugs, enzyme inhibitors, and metal-chelating agents. Recent studies have highlighted its utility in medicinal chemistry, particularly in the development of novel therapeutic agents targeting infectious diseases, cancer, and neurological disorders.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the use of 1H-Imidazole-1-carboxaldehyde as a precursor for the synthesis of potent histone deacetylase (HDAC) inhibitors. The researchers utilized this compound to develop a series of novel HDAC inhibitors with improved selectivity and reduced off-target effects, showing promising results in preclinical models of leukemia. The study emphasized the compound's role in facilitating the introduction of imidazole moieties into drug candidates, which enhanced their binding affinity and pharmacokinetic properties.

In the field of antimicrobial research, 1H-Imidazole-1-carboxaldehyde has been employed as a scaffold for designing new antifungal agents. A 2024 paper in Bioorganic & Medicinal Chemistry Letters reported the synthesis of imidazole-carboxaldehyde derivatives with potent activity against Candida albicans and Aspergillus fumigatus. The derivatives exhibited low cytotoxicity to human cells, suggesting their potential as safe and effective antifungal drugs. The study also explored the mechanism of action, revealing that these compounds disrupt fungal cell wall biosynthesis by inhibiting key enzymes.

Another notable application of 1H-Imidazole-1-carboxaldehyde is in the development of metal-chelating agents for diagnostic and therapeutic purposes. A recent study in Chemical Communications (2024) described the synthesis of imidazole-carboxaldehyde-based ligands for gadolinium(III) complexes, which showed enhanced relaxivity and stability for magnetic resonance imaging (MRI) contrast agents. The researchers attributed these improvements to the unique coordination properties of the imidazole-carboxaldehyde moiety, which facilitated stronger binding to gadolinium ions while maintaining biocompatibility.

Beyond its pharmaceutical applications, 1H-Imidazole-1-carboxaldehyde has also found use in chemical biology as a tool for protein modification and labeling. A 2023 Nature Chemical Biology paper detailed its application in site-specific protein conjugation, where it served as a reactive handle for introducing fluorescent probes and other functional groups. This approach enabled the study of protein-protein interactions and cellular localization with high precision, opening new avenues for proteomics research.

In conclusion, recent research has underscored the versatility and importance of 1H-Imidazole-1-carboxaldehyde (CAS: 3197-61-3) in chemical biology and pharmaceutical development. Its applications span from drug discovery to diagnostic imaging and chemical biology tools, demonstrating its broad utility across multiple disciplines. Future studies are expected to further explore its potential in targeted drug delivery systems and as a component of multifunctional therapeutic agents, solidifying its position as a valuable building block in medicinal chemistry.

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