Cas no 3144-16-9 ((1S)-(+)-Camphor-10-sulphonic acid)
(1S)-(+)-Camphor-10-sulphonic acid Chemical and Physical Properties
Names and Identifiers
-
- ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid
- (+)-CSA
- (+)-camphor-10-sulfonicacid (beta)
- (1S)-(+)-10-Camphorsulfonic acid
- 2-oxobornane-10-sulphonic acid
- (+)-camphor-10-sulphonic acid
- L-(-)-Camphor-10-sulfonic acid monohydrate
- (1S)-(+)-Camphor-10-sulphonic acid
- d-2-oxobornane-10-sulfonic acid
- D-10-CAMPHORSULFONIC ACID
- D-(+)-CAMPHOR-10-SULFONIC ACID
- D-CAMPHOR-10-SULFONIC ACID
- D(-)-CAMPHORSULFONIC ACID
- D-(+)-CAMPHOR SULFONIC ACID
- D-CAMPHORSULFONIC ACIDl
- D-(+)-camphour sulphonic acid
- (+)-β-camphorsulfonic acid
- (1S)-camphor-10-sulfonic acid
- S(+)Camphor sulfonic acid
- (1S)-(+)-Camphor-10-sulfonic acid
- (+)-10-Camphorsulfonic Acid
- ((1S,4R)-7,7-Dimethyl-2-oxobicyclo-[2.2.1]heptan-1-yl)methanesulfonic acid
- (+)-Camphor-10-sulfonic acid
- D(+)-10-Camphorsulfonic acid
- D-Camphorsulfonic acid
- 7,7-dimethyl-2-oxo-, (1S)-Bicyclo[2.2.1]heptane-1-methane sulfonic acid
- (+)-Camphor-10-sulfonic acid (β)
- (+)-camphorsulfonicac
- (1S)-(+)-10-Camphors
- (S)-10-camphorsulphonic acid
- camphersulfosaeure
- CSA
- D-(+)-10-Camphorsulfonic Acid
- D-CAMPHORSULPHONIC ACID
- D-REYCHLER'S ACID
- 1S-(+)-Camphor-10-sulfonic acid
- D-Camphor sulfonic acid
- [(1S,4R)-7,7-dimethyl-2-oxo-norbornan-1-yl]methanesulfonic acid
- CAMPHORSULFONIC ACID, (+)-
- DL-6-Oxobornane-10-sulphonic acid
- UNII-9TLZ01S15L
- 2287183-06-4
- EN300-384663
- (RS)-10-CAMPHORSULFONIC ACID
- AS-13390
- (1S)-10-camphorsulfonic acid
- NSC4167
- CAMPHORSULFONIC ACID, (+/-)-
- (R)-camphorsulfonic acid
- (+/-)-Camphor-10-sulfonic acid
- MFCD00074827
- [(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid
- (+/-)-Camphor-10-sulfonic acid, purum, >=98.0% (T)
- UNII-D8D049375Q
- Voriconazole Impurity E
- Camphor-10-sulfonic acid (beta), 98%
- (+/-)-Camphor-10-sulfonic acid, 99%
- D-Camphor sulfonic acid, United States Pharmacopeia (USP) Reference Standard
- Camphersulfosaeure [German]
- NSC-4167
- Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-
- (1S)-(+)-CSA
- Camphorsulfonic acid, d-
- (1S,4R)-10-Camphorsulfonic acid
- VORICONAZOLE IMPURITY E [EP IMPURITY]
- Camphor-10-sulfonic acid
- CAMPHORSULFONIC ACID [WHO-DD]
- ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonicacid
- Voriconazole impurity E, European Pharmacopoeia (EP) Reference Standard
- (+)-(S)-Camphor-10-sulfonic acid; (+)-2-Oxo-10-bornanesulfonic acid; (+)-Camphor-10-sulfonic acid; (+)-Camphor--sulfonic acid
- 10-Bornanesulfonic acid, 2-oxo-
- DL-10-Camphorsulfonic acid
- ((1S,4R)-7,7-DIMETHYL-2-OXOBICYCLO(2.2.1)HEPT-1-YL)METHANESULFONIC ACID
- 3144-16-9
- (1SR,4RS)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid
- (s)-camphorsulfonic acid
- (7,7-Dimethyl-2-oxobicyclo(2.2.1)hept-1-yl)methanesulphonic acid
- SCHEMBL60288
- AI3-23953
- MFCD00064157
- [(1S,4R)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid
- rel-((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid
- D-CAMPHORSULFONIC ACID [MI]
- 9TLZ01S15L
- BCP21451
- 10-Bornanesulfonic acid, 2-oxo-, (1S,4R)-(+)-
- (1S)-(+)-10-Camphorsulfonic acid, 99%
- EINECS 221-554-1
- Bicyclo(2.2.1)heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-
- D-CAMPHOR SULFONIC ACID [USP-RS]
- dl-10_camphorsulfonic acid
- [(1S,4R)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl]methanesulfonic Acid ((+)-10-Camphorsulfonic Acid)
- (+)-D-Camphor-10-sulfonic acid
- 10-Camphorsulfonic acid
- Camphor-10-sulfonic acid (beta)
- D8D049375Q
- CHEBI:55403
- Bicyclo(2.2.1)heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-
- AKOS005259156
- D77358
- Q27124276
- DTXSID00883956
- EINECS 200-949-2
- Reychler's acid
- camphor-sulfonic acid
- (1S,4R)-(+)-2-oxo-10-bornanesulfonic acid
- (?)-Camphor-10-sulfonic acid
- (+/-)-camphorsulfonic acid
- (+)-Camphor-10-sulfonic acid, purum, >=98.0% (T)
- EINECS 227-527-0
- [(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl]methanesulfonic acid
- 2-Oxo-10-bornanesulfonic acid
- J-520206
-
- MDL： MFCD00064157
- Inchi： 1S/C10H16O4S/c1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h7H,3-6H2,1-2H3,(H,12,13,14)
- InChI Key： MIOPJNTWMNEORI-GMSGAONNSA-N
- SMILES： CC1(C)[C@@H]2CC[C@@]1(CS(O)(=O)=O)C(=O)C2
- BRN： 2809675
Computed Properties
- Exact Mass: 232.07700
- Monoisotopic Mass: 231.069
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 15
- Rotatable Bond Count: 2
- Complexity: 390
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: -1
- XLogP3: 0.5
- Topological Polar Surface Area: 74.3
Experimental Properties
- Color/Form: White crystals
- Density: 1.2981 (rough estimate)
- Melting Point: ~200?°C (dec.) (lit.)
- Boiling Point: 344.46°C (rough estimate)
- Flash Point: °C
- Refractive Index: 21.5 ° (C=5, H2O)
- PH: 0.3 (200g/l, H2O)
- Solubility: Exhibit moderate solubility in HCCl.
- Water Partition Coefficient: dissolution
- Stability/Shelf Life: Stable. Protect from moisture. Incompatible with strong oxidizing agents, strong bases.
- PSA: 79.82000
- LogP: 2.35040
- Solubility: Soluble in water, slightly soluble in ethyl acetate and glacial acetic acid, insoluble in ether.
- Merck: 1734
- Sensitiveness: Hygroscopic
- Specific Rotation: 22 o (589nm, c=20, H2O 25 oC)
- Optical Activity: [α]20/D +21.5±1°, c =?10% in H2O
(1S)-(+)-Camphor-10-sulphonic acid Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Danger
- Hazard Statement： H314
- Warning Statement： P280,P305+P351+P338,P310
- Hazardous Material transportation number：UN 2585PSN2 8 / PGIII
- WGK Germany：3
- Hazard Category Code： 34
- Safety Instruction： S25-S36/37/39-S45
- FLUKA BRAND F CODES：3-10
- RTECS：ED1550000
-
Hazardous Material Identification：
- HazardClass：8
- PackingGroup：III
- TSCA：Yes
- Storage Condition：Store at room temperature
- Risk Phrases：R34
- Packing Group：III
- Safety Term：S25;S36/37/39;S45
- Packing Group：III
(1S)-(+)-Camphor-10-sulphonic acid Customs Data
- HS CODE：29147090
- Customs Data：
China Customs Code:
2914299000Overview:
2914299000. Other cycloalkanones without other oxygen-containing groups\Cyclic enone or cyclic terpenone. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:5.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, Acetone declared packaging
Summary:
2914299000. other cyclanic, cyclenic or cyclotherpenic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
(1S)-(+)-Camphor-10-sulphonic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 21360-100G-F |
(1S)-(+)-Camphor-10-sulphonic acid |
3144-16-9 | ≥98.0% | 100G |
￥926.23 | 2022-02-23 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 21360-500G-F |
(1S)-(+)-Camphor-10-sulphonic acid |
3144-16-9 | ≥98.0% | 500G |
￥2487.64 | 2022-02-23 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | C2107-5G |
(1S)-(+)-Camphor-10-sulphonic acid |
3144-16-9 | 5g |
￥267.43 | 2023-11-10 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | C2107-100G |
(1S)-(+)-Camphor-10-sulphonic acid |
3144-16-9 | 100g |
￥624.08 | 2023-11-10 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | C2107-500G |
(1S)-(+)-Camphor-10-sulphonic acid |
3144-16-9 | 500g |
￥1789.55 | 2023-11-10 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 8223110100 |
(1S)-(+)-Camphor-10-sulfonic acid |
3144-16-9 | for resolution of racemates for synthesis | 100G |
255.85 | 2021-05-17 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0683900343- 25g |
(1S)-(+)-Camphor-10-sulphonic acid |
3144-16-9 | 98% | 25g |
￥ 116.0 | 2021-05-18 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 1087520-100MG |
(1S)-(+)-Camphor-10-sulphonic acid |
3144-16-9 | 100mg |
￥9936.51 | 2023-09-08 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | S804744-2.5kg |
(1S)-(+)-10-Camphorsulfonic acid |
3144-16-9 | 99% | 2.5kg |
￥1,583.00 | 2022-08-31 | |
| ChemScence | CS-D1796-500g |
(+)-D-Camphor-10-sulfonic acid |
3144-16-9 | >98.0% | 500g |
$73.0 | 2022-04-27 |
(1S)-(+)-Camphor-10-sulphonic acid Suppliers
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(1S)-(+)-Camphor-10-sulphonic acid Related Literature
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Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
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Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
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Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
-
Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
Additional information on (1S)-(+)-Camphor-10-sulphonic acid
Introduction to (1S)-(+)-Camphor-10-sulphonic acid (CAS No. 3144-16-9)
(1S)-(+)-Camphor-10-sulphonic acid (CAS No. 3144-16-9) is a sulfonated derivative of camphor, a naturally occurring monoterpene ketone found in various plants, particularly in the families Lauraceae and Pinaceae. This compound has garnered significant attention in the field of pharmaceuticals, biotechnology, and materials science due to its unique chemical properties and versatile applications. The sulfonation at the 10-position of camphor introduces a polar sulfonyl group, enhancing its solubility in water and making it a valuable intermediate in synthetic chemistry.
The structure of (1S)-(+)-Camphor-10-sulphonic acid features a bicyclic framework consisting of a cyclohexane ring fused with a cyclopentane ring, with the sulfonyl group attached to the 10-position carbon. This stereochemistry, specifically the (1S)-configuration, is crucial for its biological activity and interactions with biological targets. The compound’s ability to mimic certain natural products has made it a subject of intense research in drug discovery.
In recent years, (1S)-(+)-Camphor-10-sulphonic acid has been explored for its potential in medicinal chemistry. Its sulfonated nature makes it an excellent candidate for developing bioactive molecules, including enzyme inhibitors and receptor ligands. For instance, studies have shown that derivatives of this compound exhibit inhibitory activity against various enzymes involved in metabolic pathways relevant to diseases such as diabetes and cancer. The hydrophilic character imparted by the sulfonyl group facilitates better absorption and distribution within biological systems, making it an attractive scaffold for drug design.
One of the most compelling aspects of (1S)-(+)-Camphor-10-sulphonic acid is its role as a chiral auxiliary in asymmetric synthesis. Chiral compounds are essential in pharmaceuticals because they often exist as enantiomers with different biological activities. The enantiomerically pure form of this compound can be used to induce stereochemical control during synthetic processes, ensuring the production of high-purity enantiomerically active pharmaceuticals. This has significant implications for the development of targeted therapies, where the specificity of drug action is paramount.
Furthermore, (1S)-(+)-Camphor-10-sulphonic acid has found applications in material science, particularly in the development of functional polymers and coatings. Its ability to act as a crosslinking agent or modifier enhances the properties of polymers, making them more suitable for use in biomedical devices, such as drug-eluting stents or tissue engineering scaffolds. The compound’s stability under various conditions and its compatibility with other functional groups make it a versatile additive in polymer chemistry.
Recent research has also highlighted the potential of (1S)-(+)-Camphor-10-sulphonic acid in nanotechnology. Its sulfonated structure allows it to interact with nanoparticles, facilitating their functionalization for specific applications such as targeted drug delivery or biosensing. The compound’s ability to stabilize nanoparticles while maintaining their size and morphology makes it an invaluable tool in nanomedicine.
The synthesis of (1S)-(+)-Camphor-10-sulphonic acid typically involves the sulfonation of camphor using reagents such as sulfur trioxide or chlorosulfonic acid, followed by stereoselective resolution if necessary. Advances in synthetic methodologies have improved the efficiency and yield of this process, making it more accessible for industrial-scale production. The availability of high-purity grades ensures that researchers can explore its full potential without compromising on quality.
From a regulatory perspective, (1S)-(+)-Camphor-10-sulphonic acid is not classified as a hazardous or controlled substance, which simplifies its handling and distribution. However, researchers must adhere to standard laboratory practices to ensure safety when working with organic compounds. The compound’s low toxicity profile makes it suitable for extensive use in both academic and industrial settings.
In conclusion, (1S)-(+)-Camphor-10-sulphonic acid (CAS No. 3144-16-9) is a multifaceted compound with broad applications across multiple scientific disciplines. Its unique chemical properties make it an invaluable tool in pharmaceutical development, material science, and nanotechnology. As research continues to uncover new applications and refine synthetic methods, this compound is poised to play an even greater role in advancing scientific discovery and technological innovation.
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