Cas no 306936-05-0 (5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde)

5-[4-Fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde is a fluorinated aromatic aldehyde featuring a furan core substituted with a 4-fluoro-3-(trifluoromethyl)phenyl group. This compound is of interest in synthetic organic chemistry due to its electron-withdrawing substituents, which enhance reactivity in nucleophilic addition and condensation reactions. The presence of both fluorine and trifluoromethyl groups contributes to its potential utility in the development of pharmaceuticals, agrochemicals, and advanced materials, where such moieties often improve metabolic stability and lipophilicity. Its well-defined structure and high purity make it suitable for precise synthetic applications, including the preparation of heterocyclic derivatives and functionalized intermediates. The compound is typically handled under controlled conditions due to its aldehyde functionality.
5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde structure
306936-05-0 structure
Product Name:5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde
CAS No:306936-05-0
MF:C12H6F4O2
MW:258.168457508087
MDL:MFCD01571138
CID:300190
PubChem ID:2781788
Update Time:2025-05-24

5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde Chemical and Physical Properties

Names and Identifiers

    • 2-Furancarboxaldehyde,5-[4-fluoro-3-(trifluoromethyl)phenyl]-
    • 5-[4-Fluoro-3-(trifluoromethyl)-phenyl]-2-furaldehyde
    • 5-[4-Fluoro-3-(trifluoromethyl)phenyl]-2-furaldehyde
    • 5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde
    • AC1MD0UJ
    • CTK4G5682
    • MolPort-000-146-471
    • SBB101981
    • SEW06189
    • AKOS009157942
    • MFCD01571138
    • CS-0327990
    • SB61980
    • FT-0619906
    • AS-9322
    • 5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-furaldehyde, AldrichCPR
    • DTXSID70381858
    • CHEMBL4453269
    • ACETALDEHYDEAMMONIA
    • 306936-05-0
    • 5-(4-Fluoro-3-(trifluoromethyl)phenyl)furan-2-carbaldehyde
    • CBNXGQUIJRGZRX-UHFFFAOYSA-N
    • MDL： MFCD01571138
    • Inchi： 1S/C12H6F4O2/c13-10-3-1-7(5-9(10)12(14,15)16)11-4-2-8(6-17)18-11/h1-6H
    • InChI Key： CBNXGQUIJRGZRX-UHFFFAOYSA-N
    • SMILES： FC1=CC=C(C=C1C(F)(F)F)C1=CC=C(C=O)O1

Computed Properties

  • Exact Mass: 258.03000
  • Monoisotopic Mass: 258.03039208g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 18
  • Rotatable Bond Count: 3
  • Complexity: 305
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.4
  • Topological Polar Surface Area: 30.2?2

Experimental Properties

  • Melting Point: 89 °C
  • PSA: 30.21000
  • LogP: 3.91700

5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde Security Information

  • Hazard Category Code： 36/37/38-36-25
  • Safety Instruction： S24/25
  • Hazardous Material Identification： T
  • Safety Term：S24/25

5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde Customs Data

  • HS CODE：2932190090
  • Customs Data：

    China Customs Code:

    2932190090

    Overview:

    2932190090 Other structurally non fused furan ring compounds. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde Pricemore >>

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5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde Related Literature

Additional information on 5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde

5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde (CAS No: 306936-05-0)

5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde, also known by its CAS number 306936-05-0, is a highly specialized organic compound with significant applications in the fields of pharmaceuticals and materials science. This compound has garnered attention due to its unique chemical structure and promising properties, which have been extensively studied in recent years.

The molecular structure of 5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde consists of a furan ring substituted with a carbaldehyde group at position 2 and a fluorinated aromatic ring at position 5. The presence of the trifluoromethyl group and the fluorine atom introduces significant electron-withdrawing effects, which influence the compound's reactivity and stability. This makes it an attractive candidate for various chemical transformations and applications.

Recent studies have highlighted the potential of 5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde in drug design. Researchers have explored its ability to act as a precursor for bioactive molecules, particularly in the development of anti-cancer agents. The compound's ability to form stable complexes with metal ions has also been investigated, suggesting its potential use in catalytic processes and as a ligand in coordination chemistry.

In addition to its pharmaceutical applications, CAS No: 306936-05-0 has shown promise in materials science. Its unique electronic properties make it a candidate for use in organic electronics, such as semiconductors and light-emitting diodes (LEDs). Recent advancements in synthesis techniques have improved the yield and purity of this compound, making it more accessible for large-scale applications.

The synthesis of 5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde involves a multi-step process that typically includes Friedel-Crafts alkylation followed by oxidation to introduce the aldehyde group. The optimization of these steps has been a focus of recent research, with efforts directed toward enhancing reaction efficiency and minimizing environmental impact.

Furthermore, the compound's stability under various conditions has been thoroughly examined. Studies indicate that it exhibits good thermal stability and resistance to oxidation, which are critical properties for its use in high-performance materials. Its solubility characteristics also make it suitable for formulation in various pharmaceutical delivery systems.

In conclusion, CAS No: 306936-05-0, or 5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-carbaldehyde, stands out as a versatile compound with wide-ranging applications across multiple disciplines. Ongoing research continues to uncover new potentials for this compound, solidifying its position as an important molecule in contemporary chemical research.

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