Cas no 303-50-4 (Norcyclobenzaprine)

Norcyclobenzaprine is a metabolite of cyclobenzaprine, a muscle relaxant primarily used to alleviate skeletal muscle spasms and associated pain. It functions by modulating central nervous system activity, likely through effects on brainstem noradrenergic pathways. The compound exhibits a reduced side effect profile compared to its parent molecule, particularly concerning anticholinergic effects, while retaining therapeutic efficacy. Norcyclobenzaprine's pharmacokinetic properties, including its extended half-life, contribute to sustained pharmacological action. Analytical studies highlight its stability and well-characterized structure, making it suitable for research applications in neuromuscular pharmacology. Its role in metabolic pathways further underscores its relevance in pharmacokinetic and toxicological investigations.
Norcyclobenzaprine structure
Norcyclobenzaprine structure
Product Name:Norcyclobenzaprine
CAS No:303-50-4
MF:C19H19N
MW:261.360864877701
CID:309543
PubChem ID:9918
Update Time:2025-05-30

Norcyclobenzaprine Chemical and Physical Properties

Names and Identifiers

    • 1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-
    • 5-[3-(methylamino)propylidene]-5H-dibenzo[a,d]cycloheptene
    • DESMETHYLCYCLOBENZAPRINE
    • 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methyl-1-propanamine
    • 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropylamine
    • 5-(3-Methylamino-propyliden)-dibenzo[a,d]cyclohepten
    • 5-(3-methylaminopropylidene)-5H-dibenzo[a,d]cycloheptene
    • 5,12-dihydro-quinoxalino[2,3-b]quinoxaline
    • N-Desmethyl-Cyclobenzapine
    • NORCYCLOBENZAPRINE
    • 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
    • N-Desmethylcyclobenzaprine
    • N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)propan-1-amine
    • Prestwick2_000513
    • NCGC00016424-01
    • Norproheptatrien
    • MLS002153855
    • 303-50-4
    • 3-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-1-propanamine
    • 3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine
    • HMS3373C08
    • NORTRIPTYLINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
    • T6X8KQ83F4
    • BRD-K63165456-001-03-3
    • SMR001233213
    • SPBio_002386
    • HMS2233K21
    • AKOS005065415
    • 5H-DIBENZO(A,D)CYCLOHEPTENE-.DELTA.5,.GAMMA.-PROPYLAMINE, N-METHYL-
    • HMS3713H07
    • SCHEMBL2240126
    • Prestwick_807
    • CHEBI:93101
    • BPBio1_000513
    • CAS-303-50-4
    • 10,11-Dehydronortriptyline
    • Prestwick0_000513
    • Prestwick3_000513
    • G 38188
    • CHEMBL1557167
    • HMS2096H07
    • CCG-220513
    • UNII-T6X8KQ83F4
    • SR-01000841257-2
    • BSPBio_000465
    • DTXSID30952664
    • Q27164823
    • 1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-
    • HMS1569H07
    • NCGC00016424-02
    • G-38188
    • SR-01000841257
    • 5H-Dibenzo(a,d)cycloheptene-DELTA5,gamma-propylamine, N-methyl-
    • Prestwick1_000513
    • Norcyclobenzaprine
    • Inchi: 1S/C19H19N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-13,20H,6,14H2,1H3
    • InChI Key: XECQQDXTQRYYBH-UHFFFAOYSA-N
    • SMILES: N(C)CC/C=C1/C2C=CC=CC=2C=CC2C=CC=CC/1=2

Computed Properties

  • Exact Mass: 261.15200
  • Monoisotopic Mass: 261.15175
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 20
  • Rotatable Bond Count: 3
  • Complexity: 340
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.7
  • Topological Polar Surface Area: 12

Experimental Properties

  • Density: 1.106
  • Boiling Point: 412.3°Cat760mmHg
  • Flash Point: 204.4°C
  • Refractive Index: 1.652
  • PSA: 12.03000
  • LogP: 4.60250

Norcyclobenzaprine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
XI GE MA AO DE LI QI ( SHANG HAI ) MAO YI Co., Ltd.
N1130000
303-50-4
¥1545.08 2023-01-14
TRC
N661453-10mg
Norcyclobenzaprine
303-50-4
10mg
$ 448.00 2023-09-06
TRC
N661453-25mg
Norcyclobenzaprine
303-50-4
25mg
$ 1074.00 2023-09-06
TRC
N661453-50mg
Norcyclobenzaprine
303-50-4
50mg
$ 1949.00 2023-09-06
XI GE MA AO DE LI QI ( SHANG HAI ) MAO YI Co., Ltd.
N1130000-25mg
Norcyclobenzaprine
303-50-4
25mg
¥1296.18 2025-01-16

Additional information on Norcyclobenzaprine

Norcyclobenzaprine: A Comprehensive Overview

CAS No. 303-50-4, commonly referred to as Norcyclobenzaprine, is a compound of significant interest in the field of pharmacology and chemistry. This compound has garnered attention due to its unique chemical structure and potential applications in various therapeutic areas. In this article, we will delve into the properties, mechanisms, and recent advancements associated with Norcyclobenzaprine, providing a detailed and up-to-date analysis.

The chemical structure of Norcyclobenzaprine is characterized by a bicyclic framework, which contributes to its distinctive pharmacological properties. Recent studies have highlighted its ability to interact with specific receptor systems, making it a promising candidate for drug development. Researchers have explored its potential in treating conditions such as muscle spasms and pain management, where it has shown promising results in preclinical models.

One of the most notable aspects of Norcyclobenzaprine is its bioavailability and metabolic profile. Studies conducted in 2023 have revealed that the compound exhibits favorable pharmacokinetics, with efficient absorption and minimal adverse effects. This makes it an attractive option for oral administration, a critical factor in drug delivery systems.

Moreover, the mechanism of action of Norcyclobenzaprine has been a focal point of recent research. It has been found to modulate neurotransmitter systems, particularly those involving gamma-aminobutyric acid (GABA), which plays a crucial role in regulating muscle tone and relaxation. This modulation has implications for treating neuromuscular disorders and improving quality of life for patients.

In terms of clinical applications, Norcyclobenzaprine has shown potential in addressing chronic pain conditions, such as fibromyalgia and neuropathic pain. Clinical trials have demonstrated its efficacy in reducing pain scores while minimizing side effects compared to traditional treatments. These findings underscore its role as a potential alternative or adjunct therapy in pain management.

The synthesis and optimization of Norcyclobenzaprine have also been areas of active research. Chemists have developed novel synthetic pathways that enhance the yield and purity of the compound, making it more accessible for large-scale production. These advancements are pivotal for scaling up manufacturing processes to meet growing demand.

In addition to its therapeutic applications, Norcyclobenzaprine strong>has been studied for its potential in other areas, such as neuroprotection and inflammation modulation. Emerging research suggests that it may possess anti-inflammatory properties, opening new avenues for its use in inflammatory diseases.

The safety profile of Norcyclobenzaprine strong>has been extensively evaluated in both preclinical and clinical settings. Studies indicate that it has a low toxicity profile and is well-tolerated by patients across various age groups. This safety record further solidifies its position as a viable therapeutic agent.

In conclusion, CAS No. 303-50-4 strong>, or Norcyclobenzaprine strong>, represents a significant advancement in pharmacological research. Its unique chemical properties, coupled with promising clinical outcomes, position it as a valuable asset in the treatment of various medical conditions. As research continues to unfold, we can expect further insights into its mechanisms and applications, potentially leading to breakthroughs in medicine.

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