Cas no 50-48-6 (Amitriptyline)

Amitriptyline structure
Amitriptyline structure
Product Name:Amitriptyline
CAS No:50-48-6
MF:C20H23N
MW:277.40332531929
CID:33478
PubChem ID:2160
Update Time:2025-04-18

Amitriptyline Chemical and Physical Properties

Names and Identifiers

    • Amitriptyline
    • 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene
    • 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
    • 5-(3-dimethylaminopropylidene)-10,11-dihyro-5h-dibenzo(a,d)cycloheptene
    • 5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
    • 5-(3-Dimethylpropylidene)dibenzo(a,d)(1,4)cycloheptadiene
    • 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
    • 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)-10,11-dihydrocycloheptene
    • 5-(gamma-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene
    • 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine
    • 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
    • AMITRIPTYLLINE
    • Potato Dextrose Agar
    • 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,N-dimethylpropan-1-amine
    • 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
    • 1806D8D52K
    • 5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-
    • EINECS 200-041-6
    • 5-(gamma-Dimethylaminopropylidene)-10 11-dihydro-5H-dibenzo[a d]cycloheptene
    • NCGC00015095-04
    • Tryptanol
    • Redomex
    • 5-(.gamma.-Dimethylaminopropylidene)-5H-dibenzo(a,d)-10,11-dihydrocycloheptene
    • 50-48-6
    • 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta5,gamma-propylamine
    • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-
    • 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-.DELTA.5,.gamma.-propylamine
    • AB00053417_13
    • KBio2_007397
    • cMAP_000001
    • SCHEMBL7824
    • 5-(.gamma.-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene
    • CHEBI:2666
    • C06824
    • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-
    • dimethyl({3-[(2Z)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine
    • 5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]-cycloheptadiene
    • 10,11-Dihydro-5-(.gamma.-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene
    • Amitriptyline (INN)
    • BIDD:GT0115
    • TP0
    • BRD-K53737926-003-14-6
    • NCGC00183047-01
    • NCGC00015095-12
    • Amitriptilina [INN-Spanish]
    • Amytriptiline
    • 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,d]10,11-dihydrocycloheptene
    • Prestwick3_000074
    • DTXSID7022594
    • 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene
    • AKOS000512694
    • 5-(3'-Dimetilaminopropilideno)-dibenzo-[a,d] [1,4]-cicloheptadieno
    • Laroxyl (TN)
    • 5H-dibenzo [a,d] ciclohepteno-5,.Gamma.-propilamina,10,11-dihidro-N,N-dimetil-
    • DTXCID502594
    • Damilen
    • Prestwick0_000074
    • Spectrum_000044
    • L001041
    • 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
    • BPBio1_000317
    • Amitryptyline
    • Triptisol
    • SBI-0050100.P004
    • 3-(10,11-dihydro-5H-dibenzo(a,d)(7)annulen-5-ylidene)-N,N-dimethylpropan-1-amine
    • FT-0653242
    • Laroxyl
    • PDSP1_001564
    • Elavil
    • Elani
    • KBio1_000766
    • LS-60747
    • Laroxyl (Salt/Mix)
    • AB00053417_14
    • AMITRIPTYLINE [WHO-DD]
    • KBio2_002261
    • dimethyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene]propyl})amine
    • SPBio_000082
    • amitriptylin-
    • Amitriptylinum
    • Seroten
    • KBio2_004829
    • MK 230
    • KBio3_002741
    • BSPBio_001836
    • NCGC00015095-03
    • 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
    • Q58397
    • SPBio_002208
    • Spectrum5_000806
    • Elanil
    • Adepress
    • MRF-0000533
    • 5-(3-Dimethylaminopropylidene)-5H-dibenzo[ad]-1011-dihydrocycloheptene
    • Amitril
    • MK-230
    • 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a d)(1 4)cycloheptadiene
    • Damilan
    • 5H-Dibenzo[ad]cycloheptene-Delta 5gamma-propylamine1011-dihydro-NN-dimethyl-(6CI8CI)
    • Adepril
    • 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(sup 5),gamma-propylamine
    • 5-(3''''-Dimethylaminopropylidene)-dibenzo-[a d][1 4]-cycloheptadiene
    • Lentizol (Salt/Mix)
    • NCGC00015095-08
    • Vanatrip (Salt/Mix)
    • 5-(3-Dimetilaminopropilideno)-5H-dibenzo [a,d]-10,11-dihidrociclohepteno
    • D0Y5UG
    • Ro 4-1575
    • Spectrum2_000101
    • Lopac0_000112
    • 5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
    • 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
    • Amitriptylinum (Latin)
    • N06AA09
    • BRN 2217885
    • KBioGR_000592
    • Flavyl
    • Amitryptiline
    • BRD-K53737926-003-05-4
    • CCRIS 9174
    • Lantron
    • EC 200-041-6
    • DB00321
    • Amitriptilina
    • KBioSS_002262
    • NCGC00015095-05
    • STK525215
    • 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(5),gamma-propylamine
    • NCGC00015095-02
    • AB00053417-12
    • 5-(.gamma.-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
    • AMITRIPTYLINE (MART.)
    • Triptilin
    • D07448
    • KBio2_000424
    • 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine
    • BSPBio_000287
    • Spectrum3_000298
    • Domical (Salt/Mix)
    • IDI1_000766
    • NSC169910
    • Oprea1_479304
    • GTPL200
    • Amitriprolidine
    • Laroxil
    • Sylvemid
    • KBioGR_002261
    • AmitriptylineMK-230, N-750, Ro41575
    • s5947
    • 3B - Known Drug Blood Quantification Sample
    • 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene
    • NCGC00015095-14
    • 3-(5,6-dihydrodibenzo[[?],[?]][7]annulen-11-ylidene)-N,N-dimethyl-propan-1-amine
    • Amytriptylin
    • W-109252
    • BB 0305430
    • 5-(.gamma.-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
    • NCGC00024433-04
    • Spectrum4_000146
    • Prestwick1_000074
    • Amitriptylin
    • NCGC00015095-09
    • NORTRIPTYLINE HYDROCHLORIDE IMPURITY F [EP IMPURITY]
    • UNII-1806D8D52K
    • Triptanol
    • NCGC00015095-10
    • KBio2_002992
    • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[ a,d]cyclohepten-5-ylidene)-N,N-dimethyl-
    • SDCCGSBI-0050100.P005
    • AMITRIPTYLINE [USP IMPURITY]
    • AMITRIPTYLINE [VANDF]
    • Amitriptilina [Italian]
    • KBio2_005560
    • NINDS_000766
    • 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N,N-dimethyl-
    • BDBM50020712
    • CCG-204207
    • 1-propanamina, 3-(10,11-dihidro-5H-dibenzo [a, d] ciclohepteno-5-ilideno)-N,N-dimetil-
    • N 750
    • 5H-Dibenzo(a,d)cyclopheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-n,n-dimethyl-
    • Proheptadiene
    • 3-(10,11-Dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, hydrochloride
    • AMITRIPTYLINE [MI]
    • 5H-Dibenzo[a,d]cycloheptene-Delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl- (6CI,8CI) 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
    • Elavil (TN)
    • Triptizol (Salt/Mix)
    • 10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene
    • AMITRIPTYLINE [INN]
    • CHEMBL629
    • NCGC00015095-26
    • Amitriptylin [German]
    • amitryptiline HCl
    • 5H-Dibenzo[a,d]cycloheptene-.delta.5,.gamma.-propylamine, 10,11-dihydro-N,N-dimethyl-
    • Prestwick2_000074
    • KBioSS_000424
    • N-[3-(10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDEN)PROPYL]-N,N-DIMETHYLAMINE
    • AB00514631
    • NCGC00015095-07
    • Amitriptylinum [INN-Latin]
    • [3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine
    • NCGC00015095-11
    • 10,11-dihydro-N,N-dimethl-5H-dibenzo[a,d]cycloheptene-(delta(5, gamma))-propylamine
    • 5H-Dibenzo(a,d)cycloheptene-.delta.(sup 5),.gamma.-propylamine, 10,11-dihydro-N,N-dimethyl-
    • AMITRIPTYLINE (USP IMPURITY)
    • DivK1c_000766
    • HSDB 3007
    • 5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene
    • N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
    • PS01 - Amitriptyline/Nortriptyline
    • Damitriptyline
    • PDSP2_001548
    • BCP09083
    • NCGC00015095-01
    • Lopac-A-8404
    • NCGC00015095-06
    • 10,11-dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-delta-5,gamma-propylamine
    • 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin
    • Amitriptyline [INN:BAN]
    • Sarotex
    • AMITRIPTYLINE [MART.]
    • CAS-549-18-8
    • KBio3_001336
    • 5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene
    • NS00000032
    • Amitriptylinum (INN-Latin)
    • Limbitrol
    • Amitriptilina (INN-Spanish)
    • HY-B0527
    • CS-0009498
    • DA-50424
    • BRD-K53737926-003-25-2
    • BRD-K53737926-003-27-8
    • 1ST10058
    • MDL： MFCD04971969
    • Inchi： 1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
    • InChI Key： KRMDCWKBEZIMAB-UHFFFAOYSA-N
    • SMILES： N(C)(C)CC/C=C1\C2C=CC=CC=2CCC2C=CC=CC\1=2

Computed Properties

  • Exact Mass: 277.18300
  • Monoisotopic Mass: 277.183
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 3
  • Complexity: 331
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 3.2A^2

Experimental Properties

  • Color/Form: Uncertain
  • Density: 1.076g/cm3
  • Melting Point: 196-197°C
  • Boiling Point: 398.2°C at 760mmHg
  • Flash Point: 174°C
  • Refractive Index: 1.7500 (estimate)
  • Water Partition Coefficient: 9.7 mg/mL
  • PSA: 3.24000
  • LogP: 4.16860
  • Solubility: Water solubility 9.7 mg/ml
  • pka: 9.4(at 25℃)

Amitriptyline Security Information

  • WGK Germany：3
  • Safety Instruction： S26; S36; S37/39
  • Hazardous Material Identification： Xi
  • Risk Phrases：R36/37/38
  • HazardClass：IRRITANT

Amitriptyline Customs Data

  • HS CODE：2921499090
  • Customs Data：

    China Customs Code:

    2921499090

    Overview:

    2921499090 Other aromatic monoamines and derivatives and their salts. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Amitriptyline Pricemore >>

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