- A convenient procedure for the synthesis of phenothiazine drugsGalons, Herve; Miocque, Marcel; Combet-Farnoux, Claude; Bensaid, Younes; Decodts, Guy; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(11), 5108-9
Cas no 303-14-0 (Isopromethazine)
Isopromethazine structure
Product Name:Isopromethazine
CAS No:303-14-0
MF:C17H20N2S
MW:284.419102668762
CID:308419
PubChem ID:110669
Update Time:2024-10-30
Isopromethazine Chemical and Physical Properties
Names and Identifiers
-
- 10H-Phenothiazine-10-ethanamine,N,N,b-trimethyl-
- Isopromethazine
- N,N-dimethyl-2-phenothiazin-10-ylpropan-1-amine
- N,N-dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine
- N,N,β-Trimethyl-10H-phenothiazine-10-ethanamine (ACI)
- Phenothiazine, 10-[2-(dimethylamino)-1-methylethyl]- (6CI, 7CI, 8CI)
- 10-(2-Dimethylaminoisopropyl)phenothiazine
- Fen-Bridal
- Isomethazine
- Isophenergan
- Lilly 01526
- N-[2-(Dimethylamino)-1-methylethyl]phenothiazine
- Prothiazin
- RP 3389
- RP 4460
- 303-14-0
- UNII-044033O3TY
- AKOS037479281
- PROMETHAZINE HYDROCHLORIDE IMPURITY B (EP IMPURITY)
- Q6086263
- AO-365/43506490
- DTXSID10952662
- 044033O3TY
- STL430457
- ISOPROMETHAZINE [MI]
- NS00003794
- AS-67243
- SCHEMBL141530
- N,N-dimethyl-2-(10H-phenothiazin-10-yl)-1-propanamine
- RP-4460
- phenothiazine, 10-(2-dimethylamino-1-methylethyl)-
- N-(2-(Dimethylamino)-1-methylethyl)phenothiazine
- dimethyl[2-(10H-phenothiazin-10-yl)propyl]amine
- N,N,beta-Trimethyl-10H-phenothiazine-10-ethanamine
- 10H-Phenothiazine-10-ethanamine, N,N,beta-trimethyl-
- PROMETHAZINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
- N,N,.BETA.-TRIMETHYL-10H-PHENOTHIAZINE-10-ETHANAMINE
- LILLY-01526
- CHEBI:135176
- Phenothiazine, 10-(2-(dimethylamino)-1-methylethyl)-
- ISOPROMETHAZINE [WHO-DD]
- D93130
-
- Inchi： 1S/C17H20N2S/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
- InChI Key： CGNHCKZJGQDWBG-UHFFFAOYSA-N
- SMILES： S1C2C(=CC=CC=2)N(C(CN(C)C)C)C2C1=CC=CC=2
Computed Properties
- Exact Mass: 284.1349
- Monoisotopic Mass: 284.134719
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 20
- Rotatable Bond Count: 3
- Complexity: 298
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 31.8
- XLogP3: 4.2
Experimental Properties
- Density: 1.1±0.1 g/cm3
- Boiling Point: 403.4±34.0 °C at 760 mmHg
- Flash Point: 197.8±25.7 °C
- Refractive Index: 1.622
- PSA: 6.48
- Vapor Pressure: 0.0±0.9 mmHg at 25°C
Isopromethazine Security Information
- Signal Word：warning
- Hazard Statement： H303+H313+H333
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
Isopromethazine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | I822505-250mg |
Isopromethazine |
303-14-0 | 250mg |
$ 230.00 | 2023-09-07 | ||
| TRC | I822505-500mg |
Isopromethazine |
303-14-0 | 500mg |
$397.00 | 2023-05-18 | ||
| TRC | I822505-1g |
Isopromethazine |
303-14-0 | 1g |
$724.00 | 2023-05-18 | ||
| TRC | I822505-2.5g |
Isopromethazine |
303-14-0 | 2.5g |
$1298.00 | 2023-05-18 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | D908874-25mg |
dimethyl(2-phenothiazin-10-ylpropyl)amine |
303-14-0 | 95% | 25mg |
1,800.00 | 2021-05-17 | |
| eNovation Chemicals LLC | D756152-50mg |
N,N,?-Trimethyl-10H-phenothiazine-10-ethanamine |
303-14-0 | 95% | 50mg |
$260 | 2024-06-07 | |
| eNovation Chemicals LLC | D756152-100mg |
N,N,?-Trimethyl-10H-phenothiazine-10-ethanamine |
303-14-0 | 95% | 100mg |
$430 | 2024-06-07 | |
| eNovation Chemicals LLC | D756152-250mg |
N,N,?-Trimethyl-10H-phenothiazine-10-ethanamine |
303-14-0 | 95% | 250mg |
$755 | 2024-06-07 | |
| eNovation Chemicals LLC | D756152-500mg |
N,N,?-Trimethyl-10H-phenothiazine-10-ethanamine |
303-14-0 | 95% | 500mg |
$1430 | 2024-06-07 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1609966-50mg |
N,N-dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine |
303-14-0 | 98% | 50mg |
￥3000.00 | 2024-08-02 |
Isopromethazine Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Potassium hydroxide
Reference
Production Method 2
Reaction Conditions
Reference
- Synthesis of isopromethazine hydrochlorideFry, Fred S. Jr.; Maienthal, Millard; Benson, Walter R., Journal of Pharmaceutical Sciences, 1983, 72(5), 568-9
Isopromethazine Raw materials
- Phenothiazine
- 2-Dimethylaminoisopropyl Chloride Hydrochloride
- N,N,a-Trimethyl-10H-phenothiazine-10-acetamide
Isopromethazine Preparation Products
Isopromethazine Related Literature
-
Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
-
Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
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