• 1. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 2. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 3. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 4. An amino group functionalized metal–organic framework as a luminescent probe for highly selective sensing of Fe3+ ions?
  Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665
• 5. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642

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1-(Piperazin-2-yl)ethen-1-ol Dihydrochloride: A Comprehensive Overview

1-(Piperazin-2-yl)ethen-1-ol dihydrochloride, also known by its CAS number CAS No. 3022-15-9, is a chemical compound that has garnered significant attention in the fields of pharmacology and organic synthesis. This compound is a derivative of piperazine, a six-membered ring containing two nitrogen atoms, and exhibits unique chemical properties that make it valuable in various applications. Recent studies have highlighted its potential in drug development, particularly in the design of bioactive molecules with therapeutic implications.

The structure of 1-(Piperazin-2-yl)ethen-1-ol dihydrochloride consists of a piperazine ring attached to an ethenol group, which introduces hydroxyl functionality. This structural feature contributes to its ability to form hydrogen bonds, a property that is crucial in molecular recognition and bioavailability. The dihydrochloride salt form ensures stability and solubility, making it suitable for pharmaceutical formulations. Researchers have explored its role as a building block in the synthesis of complex molecules, leveraging its reactivity and versatility.

Recent advancements in synthetic chemistry have enabled the efficient synthesis of CAS No. 3022-15-9. One notable approach involves the use of palladium-catalyzed coupling reactions, which allow for precise control over the molecule's structure. These methods not only enhance yield but also reduce reaction times, making large-scale production more feasible. Moreover, the compound's ability to undergo further functionalization has opened avenues for its use in creating libraries of compounds for high-throughput screening in drug discovery.

In terms of pharmacological activity, 1-(Piperazin-2-yl)ethen-1-ol dihydrochloride has shown promise as a modulator of ion channels and receptors. Studies conducted in vitro have demonstrated its ability to influence cellular signaling pathways, particularly those involved in neurodegenerative diseases such as Alzheimer's and Parkinson's. Its mechanism of action involves interaction with specific protein targets, leading to modulation of neuronal activity and reduction of oxidative stress.

The application of CAS No. 3022-15-9 extends beyond pharmacology into materials science. Its ability to form supramolecular assemblies has been exploited in the development of novel materials with applications in sensors and drug delivery systems. For instance, researchers have utilized its hydrogen bonding capability to create stimuli-responsive hydrogels that can release drugs in response to environmental changes such as pH or temperature.

Looking ahead, the future of 1-(Piperazin-2-yil)ethen-l-oI dihydrochloride lies in its potential as a lead compound for drug development. Ongoing clinical trials are investigating its efficacy in treating chronic pain conditions, where it has shown potential as an analgesic without inducing tolerance or dependence. Additionally, its role as a chiral catalyst in asymmetric synthesis is being explored, offering new possibilities for enantioselective reactions.

In conclusion, CAS No. 3022-l5-l9, or l-(Piperazin-Z-yil)ethen-l-oI dihydrochloride, stands as a testament to the ingenuity of modern chemistry and its applications across diverse scientific disciplines. With continued research and innovation, this compound is poised to make significant contributions to both medicine and materials science.

• 31321-68-3((2R)-piperazine-2-carboxylic acid)
• 126330-90-3((2R)-piperazine-2-carboxylic acid dihydrochloride)
• 96705-91-8(2,5-Piperazinedicarboxylicacid, cis- (9CI))
• 89601-11-6(2,6-Piperazinedicarboxylicacid)
• 75944-99-9(4-Methylpiperazine-2-carboxylic Acid Dihydrochloride)
• 89601-10-5(2,5-Piperazinedicarboxylicacid)
• 158663-69-5((S)-Piperazine-2-carboxylic acid dihydrochloride)
• 2762-32-5(Piperazine-2-carboxylic acid)
• 147650-70-2((2S)-piperazine-2-carboxylic acid)
• 133525-05-0(Piperazine-2-carboxylic acid dihydrochloride)