Production Method 1

301-00-8

112-63-0

1731-88-0

1937-62-8

112-39-0

111-82-0

110-42-9

2734-47-6

1120-25-8

75190-82-8

124-10-7

112-62-9

2733-88-2

2390-09-2

90176-52-6

112-61-8

Reaction Conditions

1.1 Catalysts: Water ;  4 h, 22 bar, 175 °C

Reference

In situ biodiesel production from wet Chlorella vulgaris under subcritical condition

Tsigie, Yeshitila Asteraye; Huynh, Lien Huong; Ismadji, Suryadi; Engida, Adam Mekonnen; Ju, Yi-Hsu, Chemical Engineering Journal (Amsterdam, 2012, 213, 104-108

Methyl Linolenate Preparation Products

• Methyl linoleate (112-63-0)
• Methyl tridecanoate (1731-88-0)
• Methyl Elaidate Standard (1937-62-8)
• Methyl palmitate (112-39-0)
• Methyl Linolenate (301-00-8)
• Methyl laurate (111-82-0)
• Methyl decanoate (110-42-9)
• Eicosapentaenoic acid methyl ester (2734-47-6)
• METHYL PALMITOLEATE (1120-25-8)
• (10Z)-10-Heptadecenoic Acid Methyl Ester (75190-82-8)
• Methyl myristate (124-10-7)
• Methyl oleate (112-62-9)
• Methyl Nervonate (2733-88-2)
• Methyl cis-11-Eicosenoate (2390-09-2)
• 10-Pentadecenoic acid,methyl ester, (10Z)- (90176-52-6)
• Methyl stearate (112-61-8)

• 1. Quantification of FAMEs in biodiesel blends of various sources by gas chromatography tandem mass spectrometry
  Syed Ghulam Musharraf,Muhammad Arif Ahmed,Noureen Zehra Anal. Methods 2015 7 3372
• 2. Development of a reduced pressure headspace solid-phase microextraction-gas chromatography/mass spectrometric (rpHSSPME-GC/MS) method and application to aroma analysis
  Changgook Lee,Younghoon Lee,Jae-Gon Lee,Alan J. Buglass Anal. Methods 2015 7 6504
• 3. New reports on anti-bacterial and anti-candidal activities of fatty acid methyl esters (FAME) obtained from Scenedesmus bijugatus var. bicellularis biomass
  Davoodbasha MubarakAli,Ramasamy Praveenkumar,Thiyagarajan Shenbagavalli,Thayalan Mari Nivetha,Abdulazees Parveez Ahamed,Naif Abdullah Al-Dhabi,Nooruddin Thajuddin RSC Adv. 2012 2 11552
• 4. Application of olefin metathesis in oleochemistry: an example of green chemistry
  J. C. Mol Green Chem. 2002 4 5
• 5. Second-order calibration for the determination of fatty acids in pomegranate seeds by vortex-assisted extraction-dispersive liquid–liquid micro-extraction and gas chromatography-mass spectrometry
  Mohammad Ahmadvand,Hassan Sereshti,Hadi Parastar RSC Adv. 2015 5 11633

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Lineolic acids and derivatives

Recent Advances in Methyl Linolenate (301-00-8) Research: Implications for Chemical Biology and Pharmaceutical Applications

Methyl linolenate (CAS: 301-00-8), a methyl ester of linolenic acid, has garnered significant attention in recent years due to its diverse biological activities and potential applications in the chemical, biological, and pharmaceutical fields. This research brief synthesizes the latest findings on methyl linolenate, focusing on its molecular mechanisms, therapeutic potential, and industrial relevance. The compound's unique chemical structure, characterized by three double bonds, underpins its reactivity and functionality in various biochemical pathways.

Recent studies have explored methyl linolenate's role in modulating inflammatory responses and oxidative stress. A 2023 study published in the Journal of Lipid Research demonstrated that methyl linolenate exhibits potent anti-inflammatory effects by inhibiting the NF-κB signaling pathway in macrophages. This finding suggests its potential as a lead compound for developing novel anti-inflammatory agents. Additionally, research in Free Radical Biology and Medicine highlighted its antioxidant properties, which are attributed to its ability to scavenge reactive oxygen species (ROS) and enhance cellular defense mechanisms.

In the pharmaceutical sector, methyl linolenate has been investigated for its neuroprotective effects. A 2024 preclinical study reported in Neuropharmacology revealed that the compound could mitigate neuronal damage in models of Alzheimer's disease by reducing amyloid-beta aggregation and tau hyperphosphorylation. These results position methyl linolenate as a promising candidate for further drug development in neurodegenerative disorders. Furthermore, its role in lipid metabolism has been elucidated in recent metabolic studies, where it was shown to regulate key enzymes involved in fatty acid oxidation and synthesis.

From an industrial perspective, methyl linolenate's applications extend to biodegradable polymers and green chemistry. A breakthrough study in ACS Sustainable Chemistry & Engineering detailed its use as a renewable feedstock for producing polyhydroxyalkanoates (PHAs), a class of biodegradable plastics. This aligns with global efforts to transition toward sustainable materials. Moreover, advancements in catalytic processes have improved the efficiency of methyl linolenate production from plant-based oils, enhancing its commercial viability.

Despite these promising developments, challenges remain in optimizing the bioavailability and stability of methyl linolenate for therapeutic use. Recent pharmacokinetic studies have identified formulation strategies, such as nanoemulsions and liposomal encapsulation, to address these limitations. Collaborative research between academia and industry is crucial to translating these findings into clinical and industrial applications. Future directions may include large-scale clinical trials and the exploration of synergistic effects with other bioactive compounds.

In conclusion, methyl linolenate (301-00-8) represents a multifaceted compound with significant potential in chemical biology and pharmaceutical research. Its anti-inflammatory, antioxidant, and neuroprotective properties, coupled with industrial applications, underscore its importance in advancing both human health and sustainable technologies. Continued research and innovation will be essential to fully unlock its capabilities and integrate it into practical solutions.

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