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  Xiaoyan Tan,Yanlin Zhou,Li Shen,Han Jia,Xiaorong Tan RSC Adv. 2019 9 37067
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• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Introduction to Ethyl 4-bromobutanoate (CAS No. 2969-81-5)

Ethyl 4-bromobutanoate, with the chemical formula C₆H₁₁BrO₂ and CAS number 2969-81-5, is an important compound in the field of organic chemistry and pharmaceutical research. This ester derivative of butanoic acid features a bromine substituent at the fourth carbon position, making it a valuable intermediate in synthetic chemistry and drug development.

The structural uniqueness of ethyl 4-bromobutanoate lies in its ability to serve as a versatile building block for more complex molecules. The presence of the bromine atom introduces reactivity that can be exploited in various chemical transformations, including nucleophilic substitution reactions, cross-coupling reactions, and other synthetic pathways. These properties have made it a subject of interest in both academic research and industrial applications.

In recent years, ethyl 4-bromobutanoate has been explored in the development of novel pharmaceuticals. Its structural motif is found in several bioactive compounds, where the ester group and bromine atom contribute to the pharmacological activity. For instance, researchers have utilized ethyl 4-bromobutanoate as a precursor in the synthesis of compounds with potential antimicrobial and anti-inflammatory properties. The bromine atom, in particular, has been shown to enhance binding affinity to biological targets, making it a crucial feature in drug design.

The compound's role in medicinal chemistry extends beyond its use as a direct precursor. Ethyl 4-bromobutanoate has been employed in the preparation of chiral centers, which are essential for many biologically active molecules. The ability to introduce stereocenters with high enantiomeric purity is critical for developing drugs that interact selectively with biological receptors. This aspect of ethyl 4-bromobutanoate has garnered attention in the synthesis of enantiomerically pure pharmaceuticals.

Recent advancements in synthetic methodologies have further highlighted the utility of ethyl 4-bromobutanoate. Catalytic processes have been developed to streamline its incorporation into more complex molecular frameworks, improving yield and efficiency. These innovations have not only accelerated research but also opened new avenues for drug discovery. For example, palladium-catalyzed cross-coupling reactions using ethyl 4-bromobutanoate have enabled the construction of intricate heterocyclic compounds, which are known for their diverse biological activities.

The compound's significance also extends to materials science, where it has been investigated for its potential applications in polymer chemistry and material design. The ester group provides a site for polymerization reactions, allowing for the creation of novel polymeric materials with tailored properties. These materials have potential uses in coatings, adhesives, and other industrial applications where specific chemical functionalities are required.

In conclusion, ethyl 4-bromobutanoate (CAS No. 2969-81-5) is a multifaceted compound with broad applications in pharmaceuticals and materials science. Its unique structural features make it a valuable intermediate in synthetic chemistry, enabling the development of novel bioactive molecules and advanced materials. As research continues to uncover new applications for this compound, its importance in both academic and industrial settings is likely to grow.

• 3540-49-6(Butanoic acid, 4-bromo-, 2-ethoxyethyl ester)
• 3540-75-8(Butyl 4-Bromobutanoate)
• 28598-81-4(Ethyl 9-bromononanoate)
• 25542-62-5(Ethyl 6-bromohexanoate)
• 29823-18-5(Ethyl 7-bromoheptanoate)
• 29823-21-0(Ethyl 8-bromooctanoate)
• 14660-52-7(5-Bromopentanoic Acid Ethyl Ester)
• 2881-62-1(Sodium acetylide(Na2(C2)) (6CI,7CI,8CI,9CI))
• 41049-09-6(Hexanoic acid,6-bromo-, pentyl ester)
• 87213-55-6(Hexanoic acid, 6-bromo-, 1,6-hexanediyl ester)