Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry?
Organic & Biomolecular Chemistry Pub Date: 2018-03-07 DOI: 10.1039/C8OB00329G
Abstract
Two novel cyclic quaternary amine crosslinking probes are synthesized for structural mass spectrometry of protein complexes in solution and for analysis of protein interactions in organellar and whole cell extracts. Each exhibits high aqueous solubility, excellent protein crosslinking efficiencies, low collision induced dissociation (CID) energy fragmentation efficiencies, high stoichiometries of reaction, increased charges of crosslinked peptide ions, and maintenance of overall surface charge balance of crosslinked proteins.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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