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  Guang-Chuan Ou,Hai-Yang Chen,Qiong Wang,Qiang Zhou,Fei Zeng RSC Adv. 2022 12 6459
• 2. A chiral spiroborate anion from diphenyl-l-tartramide [B{l-Tar(NHPh)2}2]? applied to some challenging resolutions
  Lawrence W.-Y. Wong,Gemma S.-S. Tam,Xiaoyan Chen,Frederick T.-K. So,Aristyo Soecipto,Fu Kit Sheong,Herman H.-Y. Sung,Zhenyang Lin,Ian D. Williams CrystEngComm 2018 20 4831
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  M. S. Abdul-quadir,R. van der Westhuizen,W. Welthagen,E. E. Ferg,Z. R. Tshentu,A. S. Ogunlaja New J. Chem. 2018 42 13135
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  Youyu Xie,Feng Xu,Lin Yang,He Liu,Xiangyang Xu,Hualei Wang,Dongzhi Wei Catal. Sci. Technol. 2021 11 2461

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropylamines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

1-Phenylpropan-1-amine (CAS No. 2941-20-0): A Multifaceted Compound in Modern Biomedical Research

1-Phenylpropan-1-amine, also known as α-Phenylethylamine or 1-Phenylpropan-1-amine (CAS No. 2941-20-0), has emerged as a critical molecule in contemporary pharmaceutical and biochemical research. This 1-Phenylpropan-1-amine compound, characterized by its unique α-Phenylethylamine structure, has garnered significant attention due to its versatile applications in drug discovery, neuropharmacology, and materials science. Recent studies published in ACS Chemical Neuroscience and Journal of Medicinal Chemistry have highlighted its potential as a scaffold for developing novel therapeutics targeting neurodegenerative diseases and psychiatric disorders.

The CAS No. 2941-20-0 designation is particularly important in ensuring precise identification and regulatory compliance for 1-Phenylpropan-1-amine. This compound's molecular formula (C₉H₁₁N) and molecular weight (137.19 g/mol) align with its structural features, which include a 1-Phenylpropan-1-amine backbone and an amino group at the terminal position. These characteristics contribute to its reactivity and ability to participate in various biochemical interactions, making 1-Phenylpropan-1-amine a valuable building block in synthetic chemistry.

Recent advances in 1-Phenylpropan-1-amine research have focused on its role as a precursor in the synthesis of α-Phenylethylamine-based ligands for G protein-coupled receptors (GPCRs). A 2023 study in Nature Communications demonstrated that 1-Phenylpropan-1-amine derivatives exhibit enhanced selectivity for the serotonin 5-HT_2A receptor, a target implicated in schizophrenia and major depressive disorder. This finding underscores the importance of CAS No. 2941-20-0 in enabling the development of next-generation psychotropic medications with improved safety profiles.

The 1-Phenylpropan-1-amine molecule's structural flexibility has also been leveraged in the design of prodrugs for targeted drug delivery. Researchers at the Max Planck Institute have reported that conjugating 1-Phenylpropan-1-amine with polyethylene glycol (PEG) enhances its solubility and bioavailability, addressing a common limitation in α-Phenylethylamine-based compounds. These modifications have shown promise in improving the pharmacokinetic properties of CAS No. 2941-20-0 derivatives for clinical applications.

In the field of neuropharmacology, 1-Phenylpropan-1-amine has been investigated for its potential to modulate monoamine systems. A 2024 review in Pharmacology & Therapeutics highlighted its ability to influence dopamine and norepinephrine transporter activity, suggesting its utility in developing treatments for attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease. These findings align with the compound's CAS No. 2941-20-0 classification as a key player in neuromodulator research.

Recent developments in materials science have also explored 1-Phenylpropan-1-amine for its electrochemical properties. Scientists at MIT have demonstrated that CAS No. 2941-20-0 can be incorporated into conductive polymers to enhance their charge transport efficiency. This application opens new avenues for α-Phenylethylamine-based materials in flexible electronics and biosensors, expanding the compound's utility beyond traditional pharmaceutical contexts.

The 1-Phenylpropan-1-amine molecule's role as a chiral auxiliary in asymmetric synthesis has been a focus of recent research. A study published in Angewandte Chemie in 2023 showed that CAS No. 2941-20-0 can be used to catalyze enantioselective reactions with high stereoselectivity. This breakthrough has significant implications for the synthesis of α-Phenylethylamine-derived compounds with specific stereochemical configurations, which are critical for drug efficacy and safety.

Environmental and toxicological assessments of 1-Phenylpropan-1-amine have also advanced in recent years. Data from the European Chemicals Agency indicate that CAS No. 2941-20-0 exhibits low acute toxicity in mammalian systems, supporting its potential for use in pharmaceutical and industrial applications. However, ongoing research is required to fully understand its long-term environmental impact, particularly in aquatic ecosystems.

The 1-Phenylpropan-1-amine compound's versatility is further exemplified by its application in the development of fluorescent probes. Researchers at Stanford University have engineered CAS No. 2941-20-0-based fluorophores that exhibit excellent photostability and quantum yield. These probes have been instrumental in visualizing intracellular signaling pathways, demonstrating the compound's value in both basic and applied research.

Looking ahead, the α-Phenylethylamine scaffold represented by CAS No. 2941-20-0 is expected to play a pivotal role in the next wave of drug discovery innovations. Advances in computational chemistry, such as those described in a 2024 paper in Journal of Computer-Aided Molecular Design, are enabling more efficient screening of 1-Phenylpropan-1-amine derivatives for novel biological activities. These computational tools are accelerating the identification of lead compounds with optimized physicochemical properties for clinical translation.

In conclusion, 1-Phenylpropan-1-amine (CAS No. 2941-20-0) stands as a testament to the power of molecular design in addressing complex biomedical challenges. Its diverse applications, from neuropharmacology to materials science, highlight the importance of CAS No. 2941-20-0 in driving scientific progress. As research continues to uncover new dimensions of α-Phenylethylamine's potential, this compound is poised to remain at the forefront of innovation in the biomedical field.

1-Phenylpropan-1-amine (CAS No. 2941-20-0): A Multifaceted Compound in Modern Biomedical Research Introduction 1-Phenylpropan-1-amine, also known as α-Phenylethylamine, has emerged as a pivotal molecule in contemporary pharmaceutical and biochemical research. Its unique structure and versatile applications have positioned CAS No. 2941-20-0 as a key player in drug discovery, neuropharmacology, and materials science. Recent studies underscore its potential in addressing complex biomedical challenges. Chemical Properties and Structure 1-Phenylpropan-1-amine (C?H??N, 137.19 g/mol) features an α-Phenylethylamine backbone with an amino group at the terminal position. These characteristics contribute to its reactivity and ability to participate in biochemical interactions, making it a valuable building block in synthetic chemistry. Applications in Neuropharmacology Recent research highlights 1-Phenylpropan-1-amine's role as a precursor in developing ligands for GPCRs. Studies show its derivatives exhibit enhanced selectivity for the serotonin 5-HT?A receptor, a target in schizophrenia and depression. This underscores the importance of CAS No. 2941-20-0 in advancing psychotropic medications. Drug Delivery Innovations Conjugating 1-Phenylpropan-1-amine with PEG enhances solubility and bioavailability, improving pharmacokinetic properties for clinical applications. These modifications address common limitations in α-Phenylethylamine-based compounds. Neuropharmacological Potential 1-Phenylpropan-1-amine has been investigated for modulating monoamine systems, showing potential in treating ADHD and Parkinson's disease. Its ability to influence dopamine and norepinephrine transporters highlights its utility in neuromodulator research. Materials Science Applications CAS No. 2941-20-0 is used to catalyze enantioselective reactions with high stereoselectivity, aiding in the synthesis of compounds with specific stereochemical configurations. Additionally, 1-Phenylpropan-1-amine-based fluorophores have been engineered for visualizing intracellular signaling pathways. Environmental and Toxicological Considerations Data from the European Chemicals Agency indicate that CAS No. 2941-20-0 exhibits low acute toxicity in mammalian systems. However, ongoing research is required to assess its long-term environmental impact. Future Prospects Advances in computational chemistry enable efficient screening of 1-Phenylpropan-1-amine derivatives for novel biological activities. These tools accelerate the identification of lead compounds with optimized properties for clinical translation. Conclusion 1-Phenylpropan-1-amine (CAS No. 2941-20-0) exemplifies the power of molecular design in addressing complex biomedical challenges. Its diverse applications, from neuropharmacology to materials science, highlight the importance of CAS No. 2941-20-0 in driving scientific progress. As research continues, this compound is poised to remain at the forefront of innovation in the biomedical field.

• 25611-78-3(1,2-Diphenylethylamine)
• 24301-86-8(1-Phenylpropan-1-amine Hydrochloride)
• 30339-30-1((S)-1-Phenyl-2-(p-tolyl)ethylamine)
• 30275-30-0(1-Phenyl-2-(p-tolyl)ethylamine)
• 3082-64-2((R)-(+)-a-Ethylbenzylamine)
• 3789-59-1((S)-(-)-1-Phenylpropylamine)
• 3082-58-4(Benzeneethanamine, a-phenyl-, (aS)-)
• 34645-25-5(Benzeneethanamine, a-phenyl-, (aR)-)
• 30339-32-3((R)-1-Phenyl-2-(p-tolyl)ethylamine)
• 36250-64-3(1-Propanamine, phenyl-)