• 1. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 3. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 4. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 5. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

Professional Introduction to 2,4-Dichloro-5-fluoropyrimidine (CAS No. 2927-71-1)

2,4-Dichloro-5-fluoropyrimidine, with the chemical formula C?H?Cl?FN?, is a significant intermediate in the realm of pharmaceutical and agrochemical synthesis. This compound, identified by its CAS number 2927-71-1, has garnered considerable attention due to its versatile reactivity and utility in constructing complex molecular frameworks. Its unique structural features—comprising a pyrimidine core substituted with chlorine and fluorine atoms—make it a valuable building block for the development of novel bioactive molecules.

The importance of 2,4-Dichloro-5-fluoropyrimidine in modern chemistry cannot be overstated. It serves as a critical precursor in the synthesis of various pharmacologically relevant compounds, including antiviral, anticancer, and antimicrobial agents. The presence of both chlorine and fluorine substituents enhances its reactivity, allowing for diverse functionalization strategies that are essential for drug discovery and development. Recent advancements in synthetic methodologies have further highlighted its role as a key intermediate in streamlined synthetic routes, improving efficiency and yield.

In the context of pharmaceutical research, 2,4-Dichloro-5-fluoropyrimidine has been extensively studied for its potential in generating structurally diverse analogs with enhanced biological activity. For instance, modifications at the chloro and fluoro positions have been shown to modulate binding affinity to target enzymes and receptors. This flexibility has led to the identification of several lead compounds that are currently undergoing preclinical evaluation. The compound's ability to undergo nucleophilic substitution reactions makes it particularly useful in constructing heterocyclic scaffolds, which are prevalent in many therapeutic agents.

The agrochemical industry also benefits from the applications of 2,4-Dichloro-5-fluoropyrimidine. Its derivatives have been explored as intermediates in the synthesis of herbicides and fungicides due to their ability to interfere with essential metabolic pathways in pests and weeds. By leveraging its reactivity, chemists have developed novel agrochemicals that offer improved efficacy and environmental safety profiles. These advancements underscore the compound's broad utility beyond pharmaceuticals.

Recent research has further elucidated the mechanistic aspects of reactions involving 2,4-Dichloro-5-fluoropyrimidine. Studies employing computational chemistry techniques have provided insights into transition state structures and reaction pathways, enabling more rational design of synthetic strategies. Additionally, green chemistry approaches have been explored to minimize waste and improve sustainability in its production. These efforts align with global initiatives to promote environmentally responsible chemical synthesis.

The role of 2,4-Dichloro-5-fluoropyrimidine in medicinal chemistry is further highlighted by its incorporation into targeted therapies. For example, researchers have utilized this compound to develop inhibitors of kinases and other enzymes implicated in cancer progression. The fluorine atom, in particular, has been shown to enhance metabolic stability and binding affinity in drug candidates. Such findings continue to drive innovation in drug design and highlight the enduring relevance of this intermediate.

In conclusion, 2,4-Dichloro-5-fluoropyrimidine (CAS No. 2927-71-1) remains a cornerstone in synthetic chemistry due to its multifaceted applications across pharmaceuticals and agrochemicals. Its unique structural features and reactivity make it indispensable for constructing biologically active molecules. As research progresses, new methodologies and applications will continue to emerge, reinforcing its significance in the chemical industry.

• 213265-83-9(4,6-Dichloro-5-fluoropyrimidine)
• 2259315-63-2(2,4-dichloropyrimidine-5,6-d2)
• 6693-08-9(2,4,6-Trichloro-5-fluoropyrimidine)
• 3934-20-1(2,4-Dichloropyrimidine)
• 1983945-11-4(2,4-Dichloropyrimidine hydrochloride)
• 347418-42-2(4-Chloro-5-fluoropyrimidine)
• 1293994-86-1(2,4-Dichloro-5-fluoro(2-~13~C,~15~N_2_)pyrimidine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)