Cas no 281652-10-6 (tert-butyl 4,4-difluoropiperidine-1-carboxylate)

Tert-butyl 4,4-difluoropiperidine-1-carboxylate is a fluorinated piperidine derivative commonly employed as a versatile intermediate in organic synthesis and pharmaceutical research. The tert-butoxycarbonyl (Boc) protecting group enhances its stability and facilitates selective deprotection under mild acidic conditions, making it suitable for multi-step synthetic routes. The 4,4-difluoropiperidine moiety introduces conformational rigidity and lipophilicity, which can influence the pharmacokinetic properties of target molecules. This compound is particularly valuable in the development of bioactive molecules, including enzyme inhibitors and receptor modulators, due to its ability to impart metabolic stability and improve binding affinity. Its high purity and well-characterized reactivity further support its utility in precision chemistry applications.
tert-butyl 4,4-difluoropiperidine-1-carboxylate structure
281652-10-6 structure
Product Name:tert-butyl 4,4-difluoropiperidine-1-carboxylate
CAS No:281652-10-6
MF:C10H17F2NO2
MW:221.244290113449
MDL:MFCD11054110
CID:1071032
PubChem ID:21192511
Update Time:2025-09-28

tert-butyl 4,4-difluoropiperidine-1-carboxylate Chemical and Physical Properties

Names and Identifiers

    • tert-Butyl 4,4-difluoro-1-piperidinecarboxylate
    • 1-N-Boc-4,4-difluoropiperidine
    • [4,4']Bipiperidinyl-1-carboxylic acid tert-butyl ester
    • [4,4']-Bipiperidinyl-1-carboxylic acid tert-butyl ester
    • 1-tert-butoxycarbonyl-4,4'-bipiperidine
    • AGN-PC-00FCHI
    • N-(tert-Butoxycarbonyl)-4,4'-bipiperidine
    • N-BOC-4,4'-BIPIPERIDINE
    • SureCN118561
    • tert butyl [4,4']bipiperidinyl-1-carboxylate
    • tert-Butyl [4,4'-bipiperidine]-1-carboxylate
    • tert-butyl 4,4-difluoropiperidine-1-carboxylate
    • EN300-173653
    • AS-50767
    • AKOS015841218
    • DB-189351
    • 4,4-Difluoropiperidine-1-carboxylic acid tert-butyl ester
    • A876774
    • F1907-0037
    • MFCD11054110
    • SCHEMBL6228410
    • 1-Boc-4,4-difluoropiperidine
    • SB40820
    • STL557081
    • 281652-10-6
    • AM100618
    • CS-W001523
    • Butyl 4,4-difluoro-1-piperidinecarboxylate
    • P11051
    • SY098607
    • 4,4-Difluoro-piperidine-1-carboxylic acid tert-butyl ester
    • N-Boc-4,4-Difluoropiperidine
    • J-524664
    • BBL103271
    • MDL： MFCD11054110
    • Inchi： 1S/C10H17F2NO2/c1-9(2,3)15-8(14)13-6-4-10(11,12)5-7-13/h4-7H2,1-3H3
    • InChI Key： HHBBBPZPEBZLII-UHFFFAOYSA-N
    • SMILES： FC1(CCN(C(=O)OC(C)(C)C)CC1)F

Computed Properties

  • Exact Mass: 221.12281
  • Monoisotopic Mass: 221.123
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 3
  • Complexity: 238
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 29.5A^2
  • XLogP3: 2.3

Experimental Properties

  • Boiling Point: 247.7±40.0℃ at 760 mmHg
  • PSA: 29.54

tert-butyl 4,4-difluoropiperidine-1-carboxylate Security Information

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Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
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TRC
B809698-50mg
tert-Butyl 4,4-Difluoropiperidine-1-carboxylate
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tert-Butyl 4,4-Difluoropiperidine-1-carboxylate
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tert-Butyl 4,4-Difluoropiperidine-1-carboxylate
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SHANG HAI SHAO YUAN SHI JI Co., Ltd.
SY098607-1g
1-Boc-4,4-difluoropiperidine
 281652-10-6 ≥98%
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 ￥64.00 2025-04-15
SHANG HAI SHAO YUAN SHI JI Co., Ltd.
SY098607-5g
1-Boc-4,4-difluoropiperidine
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SHANG HAI SHAO YUAN SHI JI Co., Ltd.
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