Cas no 178181-55-0 (tert-butyl 4-fluoropiperidine-1-carboxylate)

tert-Butyl 4-fluoropiperidine-1-carboxylate is a fluorinated piperidine derivative widely used as a key intermediate in pharmaceutical synthesis and organic chemistry. Its structure features a tert-butoxycarbonyl (Boc) protecting group, which enhances stability and facilitates selective deprotection under mild acidic conditions. The incorporation of a fluorine atom at the 4-position of the piperidine ring imparts unique electronic and steric properties, making it valuable for modulating the bioactivity of drug candidates. This compound is particularly useful in the development of CNS-targeting molecules, agrochemicals, and bioactive probes due to its ability to improve metabolic stability and membrane permeability. High purity and consistent quality ensure reliable performance in multi-step synthetic routes.
tert-butyl 4-fluoropiperidine-1-carboxylate structure
178181-55-0 structure
Product Name:tert-butyl 4-fluoropiperidine-1-carboxylate
CAS No:178181-55-0
MF:C10H18FNO2
MW:203.253826618195
MDL:MFCD11054109
CID:858314
PubChem ID:25001215
Update Time:2025-07-02

tert-butyl 4-fluoropiperidine-1-carboxylate Chemical and Physical Properties

Names and Identifiers

    • tert-butyl 4-fluoropiperidine-1-carboxylate
    • 4-Fluoropiperidine-N-carboxylic acid tert-butyl ester
    • tert-Butyl-4-fluoropiperidine-1-carboxylate
    • 1-(tert-butoxycarbonyl)-4-fluoropiperidine-4-carboxylic acid
    • 1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-fluoro-4-piperidinecarboxylic acid
    • 1-Boc-4-Fluo
    • 1-Boc-4-fluoro-4-piperidinecarboxylic Acid
    • 4-fluoro-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
    • 4-fluoropiperidine-1-carboxylic acid tert-butyl ester
    • 4-fluoro-piperidine-1-carboxylic acid tert-butyl ester
    • ANW-72265
    • Boc-4-fluoropiperidine
    • HT784
    • PubChem23027
    • SureCN1476380
    • DB-003781
    • 1-Piperidinecarboxylic acid, 4-fluoro-, 1,1-dimethylethyl ester
    • s11245
    • EN300-265548
    • MFCD11054109
    • ZB1752
    • 178181-55-0
    • 1-Boc-4-fluoropiperidine
    • tert-butyl 4-Fluoropiperidine 1-carboxylate
    • W-206253
    • AB91913
    • CS-W001476
    • AKOS015897868
    • F1907-0032
    • DJLUMPJNBNIWSM-UHFFFAOYSA-N
    • 1-N-Boc-4-fluoropiperidine
    • AS-82577
    • SCHEMBL1965735
    • MDL： MFCD11054109
    • Inchi： 1S/C10H18FNO2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7H2,1-3H3
    • InChI Key： DJLUMPJNBNIWSM-UHFFFAOYSA-N
    • SMILES： FC1CCN(C(=O)OC(C)(C)C)CC1

Computed Properties

  • Exact Mass: 203.13224
  • Monoisotopic Mass: 203.13215698g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 3
  • Complexity: 205
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2
  • Topological Polar Surface Area: 29.5?2

Experimental Properties

  • PSA: 29.54

tert-butyl 4-fluoropiperidine-1-carboxylate Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Alichem
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4-Fluoropiperidine-N-carboxylic acid tert-butyl ester
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 $ 50.00 2022-06-07
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 $ 160.00 2022-06-07
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 $ 250.00 2022-06-07
Apollo Scientific
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 ￡595.00 2023-09-02
Chemenu
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Enamine
EN300-265548-1g
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