• 1. Self-assembled monolayers of diamine molecules and phosphomolybdic acid on an ITO surface
  Sang-Yoon Oh,Young-Ja Yun,Kyung-Hee Hyung,Sung-Hwan Han New J. Chem. 2004 28 495
• 2. Encapsulation of biogenic polyamines by carboxylcalix[5]arenes: when solid-state design beats recognition in solution
  Giovanna Brancatelli,Giuseppe Gattuso,Silvano Geremia,Nadia Manganaro,Anna Notti,Sebastiano Pappalardo,Melchiorre F. Parisi,Ilenia Pisagatti CrystEngComm 2016 18 5012
• 3. Bio-inspired AIE pillar[5]arene probe with multiple binding sites to discriminate alkanediamines
  Yibin Zhou,Hao Tang,Zhao-Hui Li,Linxian Xu,Lingyun Wang,Derong Cao Chem. Commun. 2021 57 13114
• 4. Bio-inspired AIE pillar[5]arene probe with multiple binding sites to discriminate alkanediamines
  Yibin Zhou,Hao Tang,Zhao-Hui Li,Linxian Xu,Lingyun Wang,Derong Cao Chem. Commun. 2021 57 13114
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• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Introduction to 1,12-Diaminododecane (CAS No. 2783-17-7)

1,12-Diaminododecane, a linear diamine with the chemical formula C₁₂H₂₆N₂, is characterized by its two terminal amino groups separated by a twelve-carbon alkyl chain. This structural configuration imparts unique physicochemical properties that make it a versatile compound in polymer chemistry, materials science, and biomedical applications. With a molecular weight of approximately 206.36 g/mol and a melting point of 4–5°C, it exists as a low-viscosity liquid at room temperature, enabling easy handling in laboratory settings. Recent advancements in synthetic methodologies have further expanded its utility in creating tailored materials with precise functionalization.

In drug delivery systems, 1,12-Diaminododecane has gained attention for its role as a spacer molecule in conjugating therapeutic agents to targeting ligands or nanoparticles. A 2023 study published in the *Journal of Controlled Release* demonstrated its efficacy in enhancing the biocompatibility and stability of polymer-based carriers for anticancer drugs. By incorporating this diamine into polyethylene glycol (PEG) conjugates via amidation reactions, researchers achieved prolonged circulation half-lives and reduced immunogenicity compared to traditional spacers such as ethylenediamine. The compound’s extended carbon chain allows for optimal distance between drug payloads and carrier surfaces, minimizing steric hindrance while maintaining functional group accessibility.

The compound’s amphiphilic nature has also been leveraged in nanoparticle synthesis. In collaboration with the University of Cambridge’s Department of Chemistry, a team reported its use as a capping agent for gold nanoparticles (Nano Letters, 2024). The terminal amino groups facilitated controlled nucleation during nanoparticle formation, resulting in uniform size distribution and enhanced surface functionalization. This approach is particularly valuable for applications requiring precise optical properties or bioconjugation capabilities.

In academic research, CAS No. 2783-17-7-derived polymers are increasingly employed as scaffolds for protein engineering and enzyme immobilization. A notable application involves the synthesis of poly(amidoamine) (PAMAM) dendrimers with tailored generation levels. A 2024 paper from *Advanced Materials* highlighted how this diamine enables higher-generation dendrimer structures without compromising branching efficiency, offering improved loading capacities for catalytic enzymes such as horseradish peroxidase (HRP). The extended alkyl chain mitigates aggregation tendencies typically observed in smaller diamine precursors.

The biomedical field has seen breakthroughs involving 1,12-Diaminododecane-based hydrogels for tissue engineering. Researchers at MIT’s Koch Institute engineered self-assembling peptide amphiphiles using this compound as a linker between hydrophilic and hydrophobic domains (Biomaterials Science, 2024). The resulting hydrogels exhibited tunable mechanical properties mimicking native extracellular matrices (ECMs), supporting adipose-derived stem cell proliferation by up to 40% over conventional scaffolds. This innovation underscores its potential in regenerative medicine and wound healing technologies.

In the realm of electronic materials, recent studies have explored its role as an organic semiconductor precursor. A collaborative effort between Stanford University and Samsung Advanced Institute of Technology demonstrated that derivatives synthesized from CAS No. 2783-17-7 exhibit charge carrier mobilities exceeding 0.5 cm2/V·s when integrated into field-effect transistor (FET) architectures (Nature Electronics, 2024). The compound’s rigid carbon backbone facilitates π-electron delocalization while maintaining solution-processability—a critical balance for scalable manufacturing of flexible electronics.

Synthetic advancements continue to refine its production pathways. Traditional methods involving the hydrogenation of dinitrododecane have been optimized to reduce energy consumption by over 30%, according to a process engineering study from ETH Zurich (Catalysis Today, Q3 2024). Novel catalyst systems incorporating palladium nanoparticles enable selective reduction under mild conditions, minimizing byproduct formation and improving yield predictability.

In analytical chemistry applications,
researchers utilize this diamine as a derivatizing agent for gas chromatography-mass spectrometry (GC-MS) analysis of carboxylic acids.
A comparative study published in *Analytica Chimica Acta* (June 2024) showed that compared to hexamethylenediamine-based reagents,
it provides superior volatility profiles
while preserving structural integrity during derivatization.
This makes it ideal for quantifying trace-level analytes in complex biological matrices such as blood plasma or urine samples.

Recent investigations into its role in supramolecular chemistry reveal fascinating self-assembly behaviors.
When combined with aromatic diacid derivatives,
it forms coiled-coil peptide mimetics capable of responding dynamically to pH changes.
Published results from Osaka University’s Institute of Scientific and Industrial Research indicate these structures could serve as stimuli-responsive drug release platforms,
achieving payload release efficiencies above 95% within physiological pH ranges.

Environmental applications are emerging through its incorporation into biodegradable plastics.
A joint project between DuPont and Wageningen University developed polycarbonate blends using this diamine
that degrade completely within six months under composting conditions.
The twelve-carbon spacer enhances crystallinity without compromising biodegradability—a key challenge addressed through molecular dynamics simulations detailed in *Macromolecules* (April 2024).

Advanced characterization techniques have provided new insights into its intermolecular interactions.
Neutron scattering studies conducted at Oak Ridge National Laboratory revealed unique hydrogen bonding networks when used as an additive in polymer electrolytes,
improving ion conductivity by up to two orders of magnitude compared to baseline systems.

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hidden technical terms continued: crosslinking density determination swelling ratio measurements tensile strength testing compressive modulus evaluation glass transition temperature determination dielectric constant measurement conductivity mapping electrochemical stability windows cyclic voltammetry window calculations charge injection efficiency measurements carrier mobility quantification field-effect mobility Hall effect measurements contact angle measurements surface energy calculations hydrophobic-hydrophilic balance assessments Fourier transform infrared spectroscopy attenuated total reflectance FTIR ATR X-ray photoelectron spectroscopy XPS depth profiling secondary ion mass spectrometry SIMS compositional mapping scanning transmission electron microscopy STEM elemental mapping grazing incidence small-angle X-ray scattering GISAXS structural analysis grazing incidence wide-angle X-ray scattering GIWAXS crystallinity mapping,

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• 112-20-9(Nonylamine)
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