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  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 2. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
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  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Quinazolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Quinazolines

Comprehensive Analysis of 4-Chloro-6-methoxy-quinazolin-7-ol (CAS No. 263400-68-6): Properties, Applications, and Industry Insights

4-Chloro-6-methoxy-quinazolin-7-ol (CAS No. 263400-68-6) is a specialized quinazoline derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique chloro-methoxy-quinazolinol structure, serves as a critical intermediate in the synthesis of bioactive molecules. Its molecular formula, C₉H₇ClN₂O₂, and precise chemical properties make it a valuable asset in drug discovery pipelines.

Recent trends in medicinal chemistry highlight the growing demand for heterocyclic compounds like 4-Chloro-6-methoxy-quinazolin-7-ol. Researchers are particularly interested in its potential as a kinase inhibitor scaffold, aligning with the surge in targeted cancer therapies. The compound’s methoxy and hydroxyl groups contribute to its solubility profile, a hot topic in drug formulation optimization discussions across platforms like PubMed and ResearchGate.

From an SEO perspective, users frequently search for "quinazoline synthesis applications" or "CAS 263400-68-6 supplier," reflecting commercial and academic interest. Analytical techniques such as HPLC purity testing and NMR characterization are also commonly associated queries, underscoring the need for rigorous quality control in its production. The compound’s stability under varying pH conditions is another trending subtopic in pharmaceutical forums.

In agrochemical applications, 4-Chloro-6-methoxy-quinazolin-7-ol derivatives are explored for their herbicidal activity, coinciding with the global push for sustainable crop protection solutions. Patent databases reveal innovative formulations combining this moiety with biodegradable adjuvants—a response to the EU’s stringent green chemistry regulations.

The compound’s crystal structure data (available in CSD repositories) enables computational drug design workflows, a methodology gaining traction due to AI-assisted molecular modeling advancements. This intersects with frequent searches for "quinazoline DFT calculations" and "SAR studies," indicating strong academic engagement.

Industrial-scale production challenges, such as regioselective chlorination during synthesis, are actively discussed in process chemistry circles. Manufacturers emphasize atom economy improvements—a key focus area in ACS Green Chemistry Institute guidelines—to reduce waste generation during quinazoline intermediate preparation.

Emerging studies suggest potential applications in material science, particularly as a ligand for metal-organic frameworks (MOFs). This aligns with the materials community’s interest in nitrogen-rich building blocks for gas storage applications, as reflected in recent Nature Materials publications.

Regulatory compliance remains crucial; while 4-Chloro-6-methoxy-quinazolin-7-ol itself isn’t classified as hazardous, its handling requires standard laboratory safety protocols. SDS documentation emphasizes proper PPE usage—a frequently searched term alongside this compound’s name in occupational health contexts.

Market analysts note steady growth in the quinazoline derivatives sector (CAGR ~5.8%), driven by oncology R&D investments. The compound’s cost-efficiency compared to analogous bicyclic heterocycles makes it attractive for generic drug development pipelines, especially in emerging markets.

For researchers, accessing high-purity CAS 263400-68-6 remains paramount. Leading suppliers now provide GC-MS certified batches with detailed chromatograms, addressing the reproducibility crisis in organic synthesis—a pain point frequently mentioned in Chemistry World editorials.

• 13790-39-1(4-chloro-6,7-dimethoxy-quinazoline)
• 183322-18-1(4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline)
• 72700-23-3(8-Chloro-1,3dioxolo4,5-Gquinazoline)
• 162363-46-4(4-Chloro-6,7-diethoxyquinazoline)
• 52791-05-6(4-chloro-7H,8H-1,4dioxino2,3-gquinazoline)
• 55496-52-1(4-Chloro-7-methoxyquinazoline)
• 27631-29-4(2,4-Dichloro-6,7-dimethoxyquinazoline)
• 33371-00-5(4-Chloro-6,7,8-trimethoxyquinazoline)
• 574745-97-4(4-Chloro-7-methoxyquinazolin-6-ol)
• 50424-28-7(4-Chloro-6-methoxyquinazoline)