• 1. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 2. Acetyl protected thiol methacrylic polymers as effective ligands to keep quantum dots in luminescent standby mode?
  Marta Liras,Isabel Quijada-Garrido,Marta Palacios-Cuesta,Sonia Mu?oz-Durieux,Olga García Polym. Chem., 2014,5, 433-442
• 3. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 4. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
• 5. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Professional Introduction to 1-(4-Aminophenyl)-2-chloroethanone (CAS No. 2631-71-2)

1-(4-Aminophenyl)-2-chloroethanone, identified by the chemical compound identifier CAS No. 2631-71-2, is a significant intermediate in the realm of organic synthesis and pharmaceutical chemistry. This compound, featuring a chlorinated ketone moiety linked to an aniline derivative, has garnered considerable attention due to its versatile applications in the development of bioactive molecules. The structural motif of 1-(4-aminophenyl)-2-chloroethanone combines the reactivity of the chloroketone group with the pharmacophoric properties of the aromatic amine, making it a valuable building block for medicinal chemists.

The synthesis of 1-(4-aminophenyl)-2-chloroethanone typically involves classical organic reactions such as chlorination and condensation processes. The chloroketone functionality allows for further functionalization via nucleophilic addition or condensation reactions, enabling the construction of more complex molecular architectures. In recent years, advancements in synthetic methodologies have refined the preparation of this compound, enhancing yield and purity while minimizing side reactions. These improvements are particularly relevant in large-scale pharmaceutical production where efficiency and cost-effectiveness are paramount.

One of the most compelling aspects of 1-(4-aminophenyl)-2-chloroethanone is its role as a precursor in the synthesis of pharmacologically active agents. The presence of both a chlorine atom and an amine group provides multiple handles for medicinal chemists to explore diverse biological targets. For instance, derivatives of this compound have been investigated for their potential in treating neurological disorders, cancer, and inflammatory conditions. The aromatic amine moiety is particularly noteworthy, as it is a common pharmacophore found in many therapeutic agents that interact with biological receptors.

Recent research has highlighted the utility of 1-(4-aminophenyl)-2-chloroethanone in the development of kinase inhibitors, which are critical in oncology treatments. Kinases play a pivotal role in cell signaling pathways, and their dysregulation is often associated with various diseases, including cancer. By modifying the structure of 1-(4-aminophenyl)-2-chloroethanone, researchers have been able to generate novel inhibitors that selectively target specific kinases. These inhibitors exhibit promising preclinical activity, demonstrating potential as lead compounds for further drug development.

The chemical properties of 1-(4-aminophenyl)-2-chloroethanone also make it a valuable tool in material science applications. For example, its ability to undergo cross-coupling reactions allows for the creation of conjugated polymers and organic semiconductors. These materials are increasingly used in electronic devices such as organic light-emitting diodes (OLEDs) and solar cells. The versatility of 1-(4-aminophenyl)-2-chloroethanone in both biological and material science contexts underscores its importance as a synthetic intermediate.

In conclusion, 1-(4-aminophenyl)-2-chloroethanone (CAS No. 2631-71-2) is a multifaceted compound with broad applications in pharmaceuticals and materials science. Its unique structural features enable diverse synthetic transformations, making it an indispensable tool for chemists and researchers. As our understanding of biological systems continues to evolve, the demand for innovative intermediates like 1-(4-aminophenyl)-2-chloroethanone is expected to grow, driving further discoveries and advancements in science and technology.

• 4209-24-9(2-chloro-1-(4-methylphenyl)ethanone)
• 110945-00-1(2-chloro-1-4-(dimethylamino)phenylethan-1-one)
• 109532-22-1(Ethanone,1-(2-amino-3-methylphenyl)-2-chloro-)
• 110872-55-4(Ethanone,1-(3-amino-4,5-dimethylphenyl)-2-chloro-)
• 129865-49-2(Ethanone,2-chloro-1-[4-(2-chloroethyl)phenyl]-)
• 164322-25-2(Ethanone, 2-chloro-1-phenyl-, radical ion(1-) (9CI))
• 27700-45-4(Ethanone, 1-(3-aminophenyl)-2,2-dichloro- (9CI))
• 21886-54-4(2-chloro-1-(3-methylphenyl)ethan-1-one)
• 21886-61-3(2-chloro-1-(3-ethylphenyl)ethan-1-one)
• 108321-66-0(Ethanone,2-chloro-1-phenyl-, labeled with carbon-14 (9CI))