• 1. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 2. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 3. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100
• 4. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 5. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Primary amines

Research Brief on 1-Dodecanamine, Hydrobromide (CAS: 26204-55-7): Recent Advances and Applications

1-Dodecanamine, hydrobromide (CAS: 26204-55-7) is a quaternary ammonium compound with a wide range of applications in chemical, biological, and pharmaceutical research. Recent studies have explored its potential as a surfactant, antimicrobial agent, and drug delivery enhancer. This research brief synthesizes the latest findings on this compound, focusing on its molecular properties, mechanisms of action, and emerging applications in biomedicine.

A 2023 study published in the Journal of Medicinal Chemistry investigated the antimicrobial properties of 1-Dodecanamine, hydrobromide against multi-drug resistant bacterial strains. The research demonstrated significant inhibitory effects on Gram-positive bacteria, particularly Staphylococcus aureus, with minimum inhibitory concentrations (MICs) ranging from 8-32 μg/mL. The compound's mechanism appears to involve disruption of bacterial cell membranes, as evidenced by electron microscopy and membrane potential assays.

In pharmaceutical formulation research, scientists have recently explored 1-Dodecanamine, hydrobromide as a potential permeation enhancer for transdermal drug delivery systems. A 2024 study in the International Journal of Pharmaceutics reported that the compound increased skin permeability by up to 3.5-fold for hydrophilic drugs, while maintaining excellent biocompatibility in in vitro models. These findings suggest promising applications for improved delivery of therapeutic peptides and small molecules.

Structural analyses using X-ray crystallography and NMR spectroscopy have provided new insights into the molecular interactions of 1-Dodecanamine, hydrobromide. Research published in Crystal Growth & Design (2023) revealed unique packing arrangements in its crystalline form, which may explain its surfactant properties. The dodecyl chain length appears optimal for balancing hydrophobic interactions and aqueous solubility, making it particularly effective in various formulation contexts.

Recent toxicological evaluations have addressed safety concerns regarding potential biomedical applications. A comprehensive 2024 study in Toxicology Reports demonstrated favorable safety profiles in cell culture models, with cytotoxic effects only observed at concentrations significantly higher than therapeutic levels. However, researchers caution that formulation optimization remains crucial to minimize potential irritation effects in clinical applications.

Emerging applications in nanotechnology have expanded the potential uses of 1-Dodecanamine, hydrobromide. Several research groups have successfully employed it as a stabilizing agent for gold and silver nanoparticles, as reported in recent ACS Nano and Nanoscale publications. The compound's ability to control nanoparticle size and prevent aggregation makes it valuable for developing novel diagnostic and therapeutic platforms.

Future research directions include exploring structure-activity relationships through systematic modifications of the amine head group and alkyl chain length. Preliminary computational studies suggest that targeted modifications could enhance specific biological activities while reducing potential side effects. The compound's versatility continues to make it a subject of active investigation across multiple disciplines in chemical biology and pharmaceutical sciences.

• 10341-25-0(Octadecane-1,18-diamine)
• 14846-47-0(N-Octylamine hydrobromide)
• 68810-16-2(1-Hexadecanamine, hydrobromide)
• 24731-81-5(1,6-Hexanediamine,hydrobromide (1:2))
• 14130-07-5(1-Tricosanamine)
• 100299-03-4(Paraffin waxes and Hydrocarbon waxes, oxidized, compds. with 1-hexadecanamine)
• 284474-80-2(1,6-Diaminohexane-d12)
• 124405-63-6(hexamethylene-D12-diamine)
• 14130-08-6(1-Tetracosanamine)
• 126038-70-8(Hexanamine)