Cas no 25515-43-9 (2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)-)

The compound 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)-, is a chalcone derivative featuring a conjugated enone system with hydroxyl substituents on the aromatic rings. Its structure imparts notable reactivity, making it useful in organic synthesis and as a precursor for heterocyclic compounds. The presence of phenolic hydroxyl groups enhances its potential as an antioxidant or metal-chelating agent. The (2E)-configuration ensures stability and predictable reactivity in cross-coupling or cyclization reactions. This compound may also serve as a scaffold in pharmaceutical research due to its structural similarity to bioactive flavonoids. Its well-defined stereochemistry and functional groups allow for precise modifications in synthetic applications.
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)- structure
25515-43-9 structure
Product Name:2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)-
CAS No:25515-43-9
MF:C15H12O3
MW:240.253984451294
CID:261442
PubChem ID:5376979
Update Time:2025-10-21

2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)- Chemical and Physical Properties

Names and Identifiers

    • 2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)-
    • (2E)-1-(2,4-Dihydroxyphenyl)-3-phenyl-2-propen-1-one
    • (2,4-dihydroxyphenyl)(2-methylpropyl) ketone
    • (2,4-dihydroxyphenyl)(2-methylpropyl)-ke
    • 1-(2,4-Dihydroxy-phenyl)-3-methyl-butan-1-on
    • 1-(2,4-Dihydroxy-phenyl)-3-methyl-butan-1-one
    • 1-(2,4-dihydroxyphenyl)-3-phenylpropenone
    • 2',4'-dihydroxy-chalcone
    • 2',4'-Dihydroxy-chalkon
    • 2,4-dihydroxyphenyl isobutyl ketone
    • AK-087
    • CTK0E8398
    • SBB091747
    • SureCN1831963
    • (E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
    • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-
    • CHEMBL105310
    • (E)-2'',4''-dihydroxychalcone
    • 1776-30-3
    • N-((1R,4r)-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide dihydrochloride
    • trans-2',4'-Dihydroxychalcone
    • CHALCONE, 2',4'-DIHYDROXY-
    • AKOS022660921
    • LMPK12120016
    • 1-(2,4-Dihydroxy-phenyl)-3-phenyl-propenone
    • MFCD00180050
    • 2'',4''-Dihydroxychalcone
    • PD000608
    • Z57101033
    • 2',4'-Dihydroxychalcone
    • SR-05000002487
    • Q63409181
    • (E)-1-(2,4-Dihydroxy-phenyl)-3-phenyl-propenone
    • BDBM50042987
    • Chalcone,4'-dihydroxy-
    • CS-0163261
    • BRD-K00721105-001-01-8
    • 2-Propen-1-one,4-dihydroxyphenyl)-3-phenyl-
    • SR-05000002487-1
    • 1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one (4)
    • 2-Benzylidene-2',4'-dihydroxyacetophenone
    • NSC-401492
    • NSC401492
    • AS-77671
    • 25515-43-9
    • 1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
    • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-, (E)-
    • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)
    • 1-(2,4-Dihydroxyphenyl)-3-phenyl-2-propen-1-one
    • (E)-2',4'-Dihydroxychalcone
    • SPECTRUM1505132
    • NCGC00096022-01
    • A906614
    • (2E)-1-(2,4-Dihydroxyphenyl)-3-phenyl-2-propen-1-one #
    • (E)-1-(2,4-dihydroxyphenyl)-3-phenyl-prop-2-en-1-one
    • M7LF69Z68L
    • CCG-214582
    • JUMSUVHHUVPSOY-RMKNXTFCSA-N
    • MDL: MFCD00180050
    • Inchi: 1S/C15H12O3/c16-12-7-8-13(15(18)10-12)14(17)9-6-11-4-2-1-3-5-11/h1-10,16,18H/b9-6+
    • InChI Key: JUMSUVHHUVPSOY-RMKNXTFCSA-N
    • SMILES: OC1C=C(C=CC=1C(/C=C/C1C=CC=CC=1)=O)O

Computed Properties

  • Exact Mass: 240.07866
  • Monoisotopic Mass: 240.078644241g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 18
  • Rotatable Bond Count: 3
  • Complexity: 305
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.5
  • Topological Polar Surface Area: 57.5?2

Experimental Properties

  • PSA: 57.53

2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)- Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Key Organics Ltd
MS-21921-1MG
(2E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
25515-43-9 >95%
1mg
£37.00 2025-02-08
Key Organics Ltd
MS-21921-5MG
(2E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
25515-43-9 >95%
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£46.00 2025-02-08
Key Organics Ltd
MS-21921-10MG
(2E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
25515-43-9 >95%
10mg
£63.00 2025-02-08
Key Organics Ltd
MS-21921-50MG
(2E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
25515-43-9 >95%
50mg
£102.00 2025-02-08
Key Organics Ltd
MS-21921-100MG
(2E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
25515-43-9 >95%
100mg
£146.00 2025-02-08

2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)- Related Literature

Additional information on 2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E)-

Introduction to 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E) and Its Significance in Modern Chemical Research

2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E), with the CAS number 25515-43-9, is a compound of significant interest in the field of chemical biology and pharmaceutical research. This molecule, featuring a conjugated system of a carbonyl group and aromatic rings, has garnered attention due to its unique structural properties and potential biological activities. The presence of hydroxyl groups at the 2 and 4 positions of the phenyl ring enhances its reactivity, making it a valuable scaffold for the development of novel therapeutic agents.

The compound's structure is characterized by a (2E) configuration, indicating the spatial arrangement of the double bond. This geometric specificity can influence its interactions with biological targets, making it a promising candidate for further investigation. The combination of a propenone core with two phenyl rings substituted at specific positions creates a molecule with potential applications in various fields, including medicinal chemistry and materials science.

In recent years, there has been growing interest in exploring the pharmacological properties of molecules containing hydroxylated aromatic rings. Studies have shown that such compounds often exhibit significant antioxidant, anti-inflammatory, and antimicrobial activities. The 1-(2,4-dihydroxyphenyl)-3-phenyl moiety in CAS no 25515-43-9 is particularly noteworthy, as it suggests a high degree of functionalization that could be exploited for drug design.

One of the most exciting aspects of this compound is its potential as a precursor for more complex molecules. Researchers have been investigating its use in synthesizing derivatives with enhanced biological activity. For instance, modifications to the hydroxyl groups or the phenyl rings could lead to compounds with improved binding affinity to specific receptors or enzymes. This flexibility makes 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E) an attractive candidate for structure-activity relationship (SAR) studies.

The synthesis of CAS no 25515-43-9 has also been optimized to ensure high yield and purity. Advanced synthetic techniques, such as palladium-catalyzed cross-coupling reactions and directed ortho-metalation strategies, have been employed to construct the desired framework efficiently. These methods not only improve the accessibility of the compound but also allow for easy modifications to explore its full potential.

Recent research has highlighted the role of this compound in developing novel therapeutic strategies. For example, studies have demonstrated its ability to inhibit certain enzymes involved in inflammatory pathways. The hydroxyl groups at the 2 and 4 positions are particularly important, as they can engage in hydrogen bonding interactions with biological targets, enhancing binding affinity. This has led to investigations into its potential use as an anti-inflammatory agent.

Another area of interest is the compound's antioxidant properties. Reactive oxygen species (ROS) are known to cause cellular damage and contribute to various diseases. Compounds with strong antioxidant activity can neutralize ROS, thereby protecting cells from oxidative stress. The aromatic rings in CAS no 25515-43-9 are well-suited for this role due to their ability to donate electrons and scavenge free radicals.

The structural features of 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-, (2E) also make it a promising candidate for material science applications. Its conjugated system and rigid framework suggest potential uses in organic electronics, such as organic light-emitting diodes (OLEDs) and photovoltaic cells. Researchers are exploring how modifications to its structure can enhance its electronic properties, making it more suitable for these applications.

In conclusion,CAS no 25515-43-9 represents a fascinating molecule with diverse potential applications. Its unique structural features and biological activities make it an attractive subject for further research. As our understanding of its properties grows,we can expect to see new synthetic methodologies and pharmacological applications emerge from this promising compound.

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