• 1. Enantiomeric helical TiO2 nanofibers modulate different peptide assemblies and subsequent cellular behaviors?
  Xu Jie,Deng Xu,Weili Wei RSC Adv., 2019,9, 29149-29153
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  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
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  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Imidazoles Substituted imidazoles

Comprehensive Overview of 1-(2,6-diethylphenyl)-1H-imidazole (CAS No. 25364-42-5): Properties, Applications, and Industry Insights

1-(2,6-diethylphenyl)-1H-imidazole (CAS No. 25364-42-5) is a specialized organic compound belonging to the imidazole class, characterized by its unique molecular structure featuring a diethylphenyl substituent. This compound has garnered significant attention in pharmaceutical and agrochemical research due to its versatile chemical properties. With the rise of green chemistry and sustainable synthesis trends, researchers are increasingly exploring its potential as a catalyst intermediate or bioactive scaffold. The compound’s thermal stability and solubility profile make it suitable for applications in material science and fine chemical manufacturing.

Recent studies highlight the role of 1-(2,6-diethylphenyl)-1H-imidazole in drug discovery, particularly in modulating enzyme inhibition pathways. Its structural similarity to histidine derivatives allows interactions with biological targets, sparking interest in anticancer and antimicrobial research. Industry forums frequently discuss its optimization for high-yield synthesis, addressing challenges like regioselectivity and purity control. As computational chemistry advances, molecular docking simulations of this compound are being leveraged to predict its binding affinity, aligning with the demand for AI-driven drug design.

From an industrial perspective, CAS No. 25364-42-5 is often referenced in patents related to corrosion inhibitors and polymeric additives. Its electron-rich imidazole ring contributes to chelation properties, making it valuable in coating formulations. Environmental concerns have also prompted investigations into its biodegradability and eco-friendly alternatives, reflecting the broader shift toward circular economy principles. Analytical techniques such as HPLC and LC-MS are critical for quality assessment, ensuring compliance with REACH and FDA guidelines.

The compound’s nomenclature—1-(2,6-diethylphenyl)-1H-imidazole—often leads to searches for IUPAC naming rules or structural analogs. Common queries include its melting point (reported ~120–125°C) and solubility in polar solvents. Suppliers emphasize batch-to-batch consistency, while academic literature explores its crystallography data and spectroscopic fingerprints (e.g., NMR and IR spectra). As precision medicine gains traction, derivatives of this compound are being screened for personalized therapeutics, further driving its relevance.

Emerging discussions link 25364-42-5 to nanotechnology applications, where its surface modification potential is tested for nanoparticle stabilization. The compound’s synergistic effects with ionic liquids are another hot topic, particularly in electrolyte formulations for energy storage devices. Regulatory updates on halogen-free flame retardants have also spotlighted its derivatives as potential candidates, underscoring the need for structure-activity relationship (SAR) studies.

In summary, 1-(2,6-diethylphenyl)-1H-imidazole (CAS No. 25364-42-5) exemplifies the intersection of multidisciplinary chemistry and industrial innovation. Its adaptability across pharma, materials, and environmental science ensures sustained interest, while advancements in automated synthesis and big data analytics promise to unlock new functionalities. Researchers and manufacturers alike must stay abreast of evolving safety protocols and market trends to maximize its potential.

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