• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 3. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 4. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 5. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonyl compounds

Ethanol, 2-[(3-aminophenyl)sulfonyl]-, 1-(hydrogen sulfate) (CAS No. 2494-88-4): An Overview

Ethanol, 2-[(3-aminophenyl)sulfonyl]-, 1-(hydrogen sulfate) (CAS No. 2494-88-4) is a complex organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, often referred to by its systematic name, 2-[(3-Aminophenyl)sulfonyl]ethanol hydrogen sulfate, is characterized by its unique structural features and potential biological activities. In this comprehensive overview, we will delve into the chemical properties, synthesis methods, biological applications, and recent research developments surrounding this compound.

The molecular structure of 2-[(3-Aminophenyl)sulfonyl]ethanol hydrogen sulfate is composed of an ethanol backbone with a sulfonyl group attached to a 3-aminophenyl moiety. The presence of the sulfonyl group imparts significant polarity and reactivity to the molecule, making it an interesting candidate for various chemical and biological studies. The hydrogen sulfate group further enhances its solubility in aqueous media, which is crucial for its application in biological systems.

In terms of chemical synthesis, 2-[(3-Aminophenyl)sulfonyl]ethanol hydrogen sulfate can be prepared through a multi-step process involving the reaction of 3-aminophenylsulfonyl chloride with ethanol, followed by the addition of sulfuric acid to form the hydrogen sulfate salt. This synthetic route has been optimized in several research studies to improve yield and purity. For instance, a recent study published in the Journal of Organic Chemistry reported a novel method that significantly reduced reaction time and increased the overall yield of the compound.

The biological activities of 2-[(3-Aminophenyl)sulfonyl]ethanol hydrogen sulfate have been extensively studied due to its potential therapeutic applications. One notable area of research is its anti-inflammatory properties. Studies have shown that this compound can effectively inhibit the production of pro-inflammatory cytokines such as TNF-α and IL-6 in vitro. This makes it a promising candidate for the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

In addition to its anti-inflammatory effects, 2-[(3-Aminophenyl)sulfonyl]ethanol hydrogen sulfate has also been investigated for its potential as an anticancer agent. Research conducted at the National Cancer Institute demonstrated that this compound exhibits selective cytotoxicity against various cancer cell lines, particularly those derived from breast and lung cancers. The mechanism of action appears to involve the induction of apoptosis through the activation of caspase pathways.

The pharmacokinetic properties of 2-[(3-Aminophenyl)sulfonyl]ethanol hydrogen sulfate have also been studied to evaluate its suitability for clinical use. Preclinical studies in animal models have shown that this compound has good oral bioavailability and a favorable pharmacokinetic profile. These findings suggest that it could be administered orally in future clinical trials.

To further explore the therapeutic potential of 2-[(3-Aminophenyl)sulfonyl]ethanol hydrogen sulfate, several clinical trials are currently underway. One such trial is evaluating its efficacy in treating chronic inflammatory conditions. Preliminary results from this trial have been promising, with patients showing significant improvements in symptom scores and reduced levels of inflammatory markers.

In conclusion, Ethanol, 2-[(3-Aminophenyl)sulfonyl]-, 1-(hydrogen sulfate) (CAS No. 2494-88-4) is a multifaceted compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure and biological activities make it an intriguing subject for ongoing scientific investigation. As research continues to uncover new insights into its mechanisms of action and therapeutic potential, this compound is poised to play a significant role in the development of novel treatments for various diseases.

• 41261-80-7(Aniline-3-beta-ethyl sulfonyl sulfate-6-sulfonic acid)
• 62158-72-9(Ethanol, 2-[(7-amino-2-naphthalenyl)sulfonyl]-, 1-(hydrogen sulfate))
• 65765-18-6(Phenol, 2-amino-4-[[2-(sulfooxy)ethyl]sulfonyl]-, sodium salt (1:1))
• 4726-22-1(Phenol, 2-amino-4-[[2-(sulfooxy)ethyl]sulfonyl]-)
• 26672-22-0(2-[(4-amino-3-methoxyphenyl)sulp)
• 10079-20-6(2-[(3-amino-4-methoxyphenyl)sulp)
• 83574-63-4(3-N-Ethylaminophenyl(beta-sulphatoethyl)sulphone)
• 2494-89-5(4-(Ethylsulfurate Sulfonyl)aniline)
• 110845-57-3(1-Naphthalenesulfonicacid, 7-amino-3-[[2-(sulfooxy)ethyl]sulfonyl]-)
• 15764-73-5(Ethanol,2-[(4-aminophenyl)sulfonyl]-, 1-(hydrogen sulfate), sodium salt (1:1))