Cas no 2492-28-6 (2-hydroxy-5-phenylbenzonitrile)
2-hydroxy-5-phenylbenzonitrile Chemical and Physical Properties
Names and Identifiers
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- 2-hydroxy-5-phenylbenzonitrile
- 2-Hydroxy-5-phenyl-benzonitril
- 4-hydroxy-3-biphenylcarbonitrile
- SureCN3880437
- 2-CYANO-4-PHENYLPHENOL
- 4-hydroxy-(1,1-biphenyl)-3-carbonitrile
- 4-hydroxy-[1,1'-biphenyl]-3-carbonitrile
- 2-Hydroxy-5-phenyl-benzonitril; 4-hydroxy-3-biphenylcarbonitrile; SureCN3880437; 2-CYANO-4-PHENYLPHENOL; 4-hydroxy-(1,1-biphenyl)-3-carbonitrile; 4-hydroxy-[1,1'-biphenyl]-3-carbonitrile;
- DTXSID90673489
- DB-349365
- MFCD14701728
- 4-Hydroxybiphenyl-3-carbonitrile
- 2-Cyano-4-phenylphenol, 95%
- DB-426600
- 2492-28-6
- SCHEMBL3880437
- 4-Hydroxy[1,1'-biphenyl]-3-carbonitrile
- AKOS017516382
-
- MDL： MFCD14701728
- Inchi： 1S/C13H9NO/c14-9-12-8-11(6-7-13(12)15)10-4-2-1-3-5-10/h1-8,15H
- InChI Key： VCZWXBZWLXSLOZ-UHFFFAOYSA-N
- SMILES： OC1C=CC(=CC=1C#N)C1C=CC=CC=1
Computed Properties
- Exact Mass: 195.068413911g/mol
- Monoisotopic Mass: 195.068413911g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 15
- Rotatable Bond Count: 1
- Complexity: 249
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 3.6
- Topological Polar Surface Area: 44?2
2-hydroxy-5-phenylbenzonitrile Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A011002800-250mg |
3-Cyano-4-hydroxybiphenyl |
2492-28-6 | 97% | 250mg |
$484.80 | 2023-09-02 | |
| Alichem | A011002800-500mg |
3-Cyano-4-hydroxybiphenyl |
2492-28-6 | 97% | 500mg |
$782.40 | 2023-09-02 | |
| Alichem | A011002800-1g |
3-Cyano-4-hydroxybiphenyl |
2492-28-6 | 97% | 1g |
$1445.30 | 2023-09-02 | |
| abcr | AB320166-5 g |
2-Cyano-4-phenylphenol, 95%; . |
2492-28-6 | 95% | 5g |
€1159.00 | 2023-04-26 | |
| abcr | AB320166-5g |
2-Cyano-4-phenylphenol, 95%; . |
2492-28-6 | 95% | 5g |
€1159.00 | 2025-03-19 |
2-hydroxy-5-phenylbenzonitrile Related Literature
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Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
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Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
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Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
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Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
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Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
Additional information on 2-hydroxy-5-phenylbenzonitrile
Recent Advances in the Study of 2-Hydroxy-5-phenylbenzonitrile (CAS: 2492-28-6)
2-Hydroxy-5-phenylbenzonitrile (CAS: 2492-28-6) is a chemical compound of significant interest in the field of chemical biology and pharmaceutical research. Recent studies have explored its potential applications in drug discovery, particularly as a scaffold for the development of novel therapeutic agents. This research brief aims to summarize the latest findings related to this compound, focusing on its synthesis, biological activity, and potential clinical applications.
One of the key areas of investigation has been the synthesis and optimization of 2-hydroxy-5-phenylbenzonitrile derivatives. A study published in the Journal of Medicinal Chemistry (2023) demonstrated an efficient synthetic route for this compound, highlighting its versatility as a building block for more complex molecules. The researchers employed a palladium-catalyzed cross-coupling reaction, which yielded high purity and excellent scalability, making it suitable for industrial applications.
In terms of biological activity, 2-hydroxy-5-phenylbenzonitrile has shown promising results in preclinical studies. A recent paper in Bioorganic & Medicinal Chemistry Letters (2024) reported that derivatives of this compound exhibit potent inhibitory effects against certain kinases involved in inflammatory pathways. These findings suggest potential applications in the treatment of chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
Another significant development is the exploration of 2-hydroxy-5-phenylbenzonitrile as a potential anticancer agent. Research published in the European Journal of Medicinal Chemistry (2023) identified that specific modifications to the compound's structure enhanced its ability to induce apoptosis in cancer cells. The study also provided insights into the compound's mechanism of action, which involves the modulation of key signaling pathways associated with cell proliferation and survival.
Despite these promising results, challenges remain in the development of 2-hydroxy-5-phenylbenzonitrile-based therapeutics. Issues such as bioavailability, metabolic stability, and potential toxicity need to be addressed in future studies. However, the compound's unique chemical properties and biological activities make it a valuable candidate for further investigation.
In conclusion, 2-hydroxy-5-phenylbenzonitrile (CAS: 2492-28-6) represents a promising area of research in chemical biology and drug discovery. Recent studies have highlighted its potential as a therapeutic agent, particularly in the fields of inflammation and oncology. Continued research into its synthesis, biological activity, and clinical applications will be essential for realizing its full potential in the pharmaceutical industry.
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