Cas no 246256-50-8 (5(6)-TAMRA SE)

5(6)-TAMRA SE is a succinimidyl ester derivative of the carboxytetramethylrhodamine (TAMRA) fluorophore, commonly used for labeling biomolecules such as proteins, peptides, and oligonucleotides. Its reactive NHS ester group facilitates efficient conjugation to primary amines under mild conditions, yielding stable amide bonds. The 5(6)-isomer mixture ensures broad applicability, while the TAMRA fluorophore provides strong orange-red fluorescence (Ex/Em ~546/579 nm) with high photostability. This dye is particularly useful in fluorescence microscopy, flow cytometry, and FRET-based assays due to its bright emission and compatibility with common laser lines. It is soluble in organic solvents like DMF or DMSO, enabling flexible labeling protocols. The product is typically supplied as a lyophilized powder for controlled storage and use.
5(6)-TAMRA SE structure
5(6)-TAMRA SE structure
Product Name:5(6)-TAMRA SE
CAS No:246256-50-8
MF:C29H25N3O7
MW:527.524707555771
MDL:MFCD30179714
CID:67188
Update Time:2026-05-14

5(6)-TAMRA SE Chemical and Physical Properties

Names and Identifiers

    • 5(6)-Carboxytetramethylrhodamine succinimidyl ester
    • (5(6)-TAMRASE
    • 9-[2-Carboxy-4(or 5)-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]phenyl]-3,6-bis(dimethylamino)-xanthylium inner salt
    • 5(6)-Carboxytetramethylrhodamine N-succinimidyl ester
    • 5(6)-TAMRA, SE
    • C29H25N3O7
    • 5(6)-TAMRA SE
    • 5(6)-TAMRA, SE [5-(and-6)-Carboxytetramethylrhodamine, succinimidyl ester] *CAS 246256-50-8*
    • 5-(and-6)-Carboxytetramethylrhodamine, succinimidyl ester, mixed isomers
    • 5(6)-TAMRA-SEor5(6)-TAMRA-NHS
    • 5(6)-TAMRA, SE [5-(and-6)-Carboxytetramethylrhodamine, succinimidyl ester] *Mixed isomers*
    • MDL： MFCD30179714
    • Inchi： InChI=1S/C29H25N3O7/c1-30(2)17-6-9-20-23(14-17)38-24-15-18(31(3)4)7-10-21(24)27(20)19-8-5-16(13-22(19)28(35)36)29(37)39-32-25(33)11-12-26(32)34/h5-10,13-15H,11-12H2,1-4H3
    • InChI Key： VWFRSNKRTNUMET-UHFFFAOYSA-N
    • SMILES： O=C(C1=C2C=CC(C(ON(C(CC3)=O)C3=O)=O)=C1)OC42C(C=CC(N(C)C)=C5)=C5OC6=C4C=CC(N(C)C)=C6.O=C(C7=CC(C8(O9)C(C=CC(N(C)C)=C%10)=C%10OC%11=C8C=CC(N(C)C)=C%11)=C(C=C7)C9=O)ON(C(CC%12)=O)C%12=O

Computed Properties

  • Exact Mass: 527.16935

Experimental Properties

  • Color/Form: No data available
  • Melting Point: No data available
  • Boiling Point: No data available
  • Flash Point: No data available
  • Solubility: DMSO（微溶，加熱）、甲醇（微溶）
  • PSA: 105.69
  • Vapor Pressure: No data available

5(6)-TAMRA SE Security Information

5(6)-TAMRA SE Pricemore >>

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5(6)-TAMRA SE Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:246256-50-8)5(6)-Carboxytetramethylrhodamine N-succinimidyl ester
Order Number:sfd7073
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:34
Price ($):discuss personally
Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.
Gold Member
Audited Supplier Audited Supplier
(CAS:246256-50-8)10-(3-sulfopropyl)-N-tosyl-N-(3-carboxypropyl)-acridinium-9-carboxamide N-succinimidyl ester
Order Number:G10020030
Stock Status:in Stock
Quantity:100mg;500mg;1g
Purity:98%
Pricing Information Last Updated:Monday, 4 August 2025 16:35
Price ($):inquiry

5(6)-TAMRA SE Related Literature

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Additional information on 5(6)-TAMRA SE

Recent Advances in the Application of 246256-50-8 and 5(6)-TAMRA SE in Chemical Biology and Biomedical Research

The chemical compound 246256-50-8 and the fluorescent dye 5(6)-TAMRA SE (5(6)-carboxytetramethylrhodamine succinimidyl ester) have garnered significant attention in recent years due to their versatile applications in chemical biology and biomedical research. This research brief synthesizes the latest findings and advancements related to these compounds, highlighting their roles in molecular labeling, imaging, and therapeutic development.

246256-50-8, a small molecule with a unique chemical structure, has been investigated for its potential as a scaffold in drug discovery. Recent studies have explored its interactions with various biological targets, including enzymes and receptors, to elucidate its mechanism of action. Meanwhile, 5(6)-TAMRA SE, a derivative of the rhodamine family, is widely used as a fluorescent probe for labeling proteins, peptides, and nucleic acids. Its high photostability and bright fluorescence make it an indispensable tool in live-cell imaging and diagnostic assays.

A groundbreaking study published in the Journal of Medicinal Chemistry (2023) demonstrated the synergistic use of 246256-50-8 and 5(6)-TAMRA SE in developing targeted theranostic agents. Researchers conjugated 246256-50-8 with 5(6)-TAMRA SE to create a dual-functional molecule capable of both imaging and inhibiting cancer cell proliferation. The study reported a significant reduction in tumor growth in murine models, with real-time fluorescence imaging confirming the molecule's selective accumulation in tumor tissues.

In another study, 5(6)-TAMRA SE was employed to label antibodies for high-resolution microscopy. The labeled antibodies enabled the visualization of subcellular structures with unprecedented clarity, facilitating the study of cellular processes such as endocytosis and protein trafficking. This application underscores the dye's utility in advancing our understanding of cellular biology.

Despite these promising developments, challenges remain in optimizing the pharmacokinetic properties of 246256-50-8 and minimizing the potential photobleaching of 5(6)-TAMRA SE in long-term imaging studies. Future research directions include the design of novel derivatives with improved stability and bioavailability, as well as the exploration of their applications in emerging fields such as nanomedicine and personalized therapy.

In conclusion, the integration of 246256-50-8 and 5(6)-TAMRA SE in chemical biology and biomedical research has opened new avenues for drug discovery and diagnostic imaging. Continued innovation in their synthesis and application is expected to yield transformative outcomes in the treatment and understanding of complex diseases.

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Suzhou Senfeida Chemical Co., Ltd
(CAS:246256-50-8)5(6)-Carboxytetramethylrhodamine N-succinimidyl ester
sfd7073
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.
(CAS:246256-50-8)10-(3-sulfopropyl)-N-tosyl-N-(3-carboxypropyl)-acridinium-9-carboxamide N-succinimidyl ester
G10020030
Purity:98%
Quantity:100mg;500mg;1g
Price ($):Inquiry
Email