Production Method 1

13939-06-5

3932-97-6

2375204-83-2

958452-21-6

176214-12-3

Reaction Conditions

1.1 Solvents: Acetonitrile ,  Water ;  16 h, pH 9.5, rt → 45 °C
1.2 Reagents: Sodium chloride Solvents: Ethanol ;  overnight, -20 °C
1.3 Reagents: Cesium hydroxide Catalysts: Palladate(1-), [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC]chloro[2′-(dicyclohexylphos… Solvents: 1-Methoxy-2-propanol ,  Water ;  15 h, 80 °C

Reference

Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis

Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; et al, Bioconjugate Chemistry, 2019, 30(8), 2209-2215

5-(Trifluoromethyl)pyrimidine-4-carboxylic acid Raw materials

• Hexacarbonylmolybdenum
• 2,4-Dichloro-5-(trifluoromethyl)pyrimidine

5-(Trifluoromethyl)pyrimidine-4-carboxylic acid Preparation Products

• 5-(Trifluoromethyl)pyrimidine-4-carboxylic acid (2375204-83-2)
• 4-Chloro-5-(trifluoromethyl)pyrimidine (958452-21-6)
• 5-(Trifluoromethyl)pyrimidine (176214-12-3)

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  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 3. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
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  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

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