• 1. Qualitative and quantitative analysis of retinol, retinyl esters, tocopherols and selected carotenoids out of various internal organs from different species by HPLC
  Michael W. Sch?ffer,Somdutta Sinha Roy,Shyamali Mukherjee,Donatus Nohr,Michael Wolter,Hans K. Biesalski,David E. Ong,Salil K. Das Anal. Methods 2010 2 1320
• 2. Comments on the determination of vitamin A in natural products and especially cod-liver oils
  R. A. Morton,F. Bro-Rasmussen Analyst 1955 80 410
• 3. Catalytic synthesis of 9-cis-retinoids: mechanistic insights
  Shirin Kahremany,Adam Kubas,Gregory P. Tochtrop,Krzysztof Palczewski Dalton Trans. 2019 48 10581
• 4. Electron transfer and energy transfer of photoexcited C60 in the presence of retinols
  Yoshiko Sasaki,Toshifumi Konishi,Mariko Yamazaki,Mamoru Fujitsuka,Osamu Ito Phys. Chem. Chem. Phys. 1999 1 4555
• 5. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis
  Shirin Kahremany,Christopher Lane Sander,Gregory P. Tochtrop,Adam Kubas,Krzysztof Palczewski Org. Biomol. Chem. 2019 17 8125

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Retinoids

9-cis-Retinol (CAS No. 22737-97-9): A Comprehensive Overview

9-cis-Retinol, also known as cis-9-retinol, is a naturally occurring isomer of retinol, a vital micronutrient that plays a critical role in various biological processes. With the CAS registry number 22737-97-9, this compound is classified as a carotenoid derivative and is extensively studied for its unique properties and applications in nutrition, cosmetics, and pharmaceuticals. This article delves into the latest research findings, structural characteristics, and functional implications of 9-cis-Retinol, providing a comprehensive understanding of its significance in both natural and synthetic contexts.

The molecular structure of 9-cis-Retinol is characterized by a long hydrocarbon chain with a hydroxyl group at one end and a conjugated double bond system. The cis configuration at the ninth carbon position distinguishes it from other retinol isomers, such as all-trans-retinol. This structural difference significantly impacts its physical properties, bioavailability, and biological activity. Recent studies have highlighted the importance of stereochemistry in determining the functionality of retinoids, emphasizing the unique role of 9-cis-Retinol in cellular processes.

One of the most notable functions of 9-cis-Retinol is its role in vision. As part of the visual cycle, it serves as a precursor to 11-cis-retinal, which is essential for phototransduction in the retina. Emerging research has explored the dynamics of retinal isomerization, revealing that 9-cis-Retinol may play a pivotal role in maintaining visual acuity under low-light conditions. Additionally, its antioxidant properties make it a valuable compound in combating oxidative stress, which is implicated in numerous chronic diseases.

Recent advancements in nutraceuticals have underscored the potential of 9-cis-Retinol as a bioactive ingredient in dietary supplements. Its ability to enhance skin health, improve immune function, and support reproductive health has been validated through clinical trials. For instance, studies published in 2023 have demonstrated that supplementation with cis-isomeric retinols can significantly reduce oxidative damage to cellular membranes, thereby promoting overall wellness.

In the cosmetics industry, 9-cis-Retinol has gained traction as an active ingredient in anti-aging products. Its ability to stimulate collagen synthesis and reduce photoaging effects has been corroborated by recent dermatological studies. Furthermore, its compatibility with other skincare ingredients makes it an ideal component for formulations targeting skin rejuvenation and protection against environmental stressors.

From a pharmacological perspective, 9-cis-Retinol exhibits potential as a therapeutic agent in treating conditions associated with retinal degeneration and oxidative stress. Preclinical studies have shown promising results in models of age-related macular degeneration (AMD), suggesting that this compound may offer novel avenues for disease intervention.

The synthesis and characterization of 9-cis-Retinol have also been subjects of recent scientific inquiry. Researchers have developed innovative methods for isolating this compound from natural sources and synthesizing it through biotechnological processes. These advancements have enhanced the scalability and cost-effectiveness of producing cis-isomeric retinols, paving the way for broader industrial applications.

In conclusion, 9-cis-Retinol (CAS No. 22737-97-9) stands out as a multifaceted compound with significant implications across various fields. Its unique stereochemical properties, coupled with emerging research findings, underscore its potential as a key player in nutrition, cosmetics, and medicine. As ongoing studies continue to unravel its mechanisms of action and therapeutic potentials, cis-9-retinol is poised to play an increasingly prominent role in advancing human health and well-being.

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