• 1. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 2. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 3. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 4. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 5. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147

Comprehensive Overview of (R)-2-Methyl-1,4-butanediol (CAS No. 22644-28-6): Properties, Applications, and Industry Trends

(R)-2-Methyl-1,4-butanediol (CAS No. 22644-28-6) is a chiral diol compound with significant relevance in pharmaceutical synthesis, specialty chemicals, and advanced material research. Its unique stereochemistry and bifunctional hydroxyl groups make it a versatile building block for asymmetric synthesis and polymer modifications. The growing demand for enantiomerically pure intermediates in drug development has propelled interest in this compound, particularly in the context of green chemistry and sustainable manufacturing processes.

The molecular structure of (R)-2-Methyl-1,4-butanediol features a four-carbon chain with hydroxyl groups at positions 1 and 4, and a methyl substituent at the chiral 2-position. This configuration enables its use as a precursor for bioactive molecules, with researchers frequently searching for "chiral diol applications" or "asymmetric synthesis building blocks." Recent studies highlight its role in creating biodegradable polymers, aligning with global trends toward circular economy principles and eco-friendly material design.

In pharmaceutical applications, (R)-2-Methyl-1,4-butanediol serves as a key intermediate for antiviral and cardiovascular drugs. Industry professionals often inquire about "CAS 22644-28-6 purity standards" and "chiral resolution techniques," reflecting the compound's importance in regulatory-compliant production. Advanced purification methods like simulated moving bed chromatography have been developed specifically for this stereoisomer, addressing the market need for high optical purity (>99% ee) in critical syntheses.

The material science sector utilizes this compound for polyurethane elastomers and specialty coatings, where searches for "bio-based polyol alternatives" have increased by 120% in two years. Its balanced hydrophilicity and chain length make it ideal for modifying polymer flexibility while maintaining thermal stability. Recent patent filings demonstrate innovative applications in shape-memory polymers responsive to physiological conditions.

Analytical characterization of 22644-28-6 typically involves chiral HPLC, polarimetry, and NMR spectroscopy. Laboratories frequently search for "spectral data for (R)-2-Methyl-1,4-butanediol" and "stereochemical stability studies," indicating the need for reliable reference standards. The compound shows excellent stability under nitrogen atmosphere but requires protection from oxidation during long-term storage.

Emerging applications in the flavor and fragrance industry leverage the compound's structural similarity to natural terpenoids. Perfumers value its potential as a precursor for woody-amber notes, coinciding with market trends toward sustainable aroma chemicals. This application aligns with increasing searches for "green fragrance ingredients" and "chiral odorants" in specialty chemical databases.

Manufacturing processes for (R)-2-Methyl-1,4-butanediol have evolved significantly, with biotechnological routes gaining prominence. The development of engineered reductase enzymes has improved the cost-efficiency of chiral production, addressing frequent queries about "enzymatic synthesis of chiral diols." Life cycle assessment studies confirm that microbial fermentation routes can reduce carbon footprint by 40% compared to traditional chemical synthesis.

Quality control specifications for CAS 22644-28-6 typically include tests for optical rotation (typically +13° to +15°), water content (<0.1%), and heavy metal contamination. These parameters respond to industry concerns about "pharmaceutical-grade chiral intermediates" and "GMP-compliant diol suppliers." Leading manufacturers now provide comprehensive technical dossiers with detailed impurity profiles to meet regulatory requirements.

In academic research, the compound's crystal structure has been extensively studied, revealing interesting hydrogen-bonding patterns that influence its physical properties. Materials scientists searching for "hydrogen-bonded diol networks" or "chiral crystal engineering" frequently reference these studies. The compound's melting point (34-36°C) and viscosity characteristics make it particularly useful for low-temperature applications.

The global market for (R)-2-Methyl-1,4-butanediol is projected to grow at 6.8% CAGR through 2030, driven by expanding applications in electronic materials and controlled drug delivery systems. Supply chain professionals increasingly search for "bulk chiral diol suppliers" and "just-in-time specialty chemical logistics," reflecting the compound's transition from laboratory-scale to industrial-scale applications.

• 616-16-0((R)-2-Methylbutanol)
• 2938-98-9(2-Methyl-1,4-butanediol)
• 19550-30-2(2,3-dimethylbutan-1-ol)
• 1565-80-6((S)-(-)-2-Methylbutanol)
• 127253-15-0((2R,3R)-2,3-dimethylbutane-1,4-diol)
• 20281-85-0(1-butanol, 2,3-dimethyl-,)
• 70423-38-0((S)-2-Methyl-1,4-butanediol)
• 34713-94-5(2-methyl-1-butanol)
• 15071-36-0((2S)-2,3-dimethylbutan-1-ol)
• 15019-27-9((2R)-2,3-Dimethyl-1-butanol)