• 1. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 2. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 3. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 4. An investigation of new infrared nonlinear optical material: BaCdSnSe4, and three new related centrosymmetric compounds: Ba2SnSe4, Mg2GeSe4, and Ba2Ge2S6?
  Kui Wu,Zhihua Yang,Shilie Pan Dalton Trans., 2015,44, 19856-19864
• 5. Aluminium complexes with thio-phosphorus ligands: syntheses and characterisations of [Al2(CyPS3)2(CyPHS2)2] and [Al(S2PPh2)3]?
  Robert P. Davies,Maria A. Giménez,Laura Patel,Andrew J. P. White Dalton Trans., 2008, 5705-5707

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines

Research Brief on Ethyl 2-(piperazin-2-yl)acetate (CAS: 226068-82-2) in Chemical Biology and Pharmaceutical Applications

Ethyl 2-(piperazin-2-yl)acetate (CAS: 226068-82-2) has emerged as a compound of significant interest in chemical biology and pharmaceutical research due to its unique structural features and potential therapeutic applications. Recent studies have focused on its role as a versatile building block in medicinal chemistry, particularly in the synthesis of novel bioactive molecules targeting neurological disorders and infectious diseases.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the compound's utility as a key intermediate in the development of selective serotonin reuptake inhibitors (SSRIs) with improved blood-brain barrier penetration. The research team utilized Ethyl 2-(piperazin-2-yl)acetate as a core scaffold to develop a series of derivatives showing enhanced binding affinity to serotonin transporters while minimizing off-target effects.

In antimicrobial research, a recent Nature Communications article (2024) reported the compound's incorporation into novel quinolone-azetidine hybrids exhibiting potent activity against multidrug-resistant Gram-positive pathogens. The piperazine moiety in Ethyl 2-(piperazin-2-yl)acetate was found to be crucial for maintaining antibacterial activity while reducing cytotoxicity in mammalian cells.

Structural optimization studies have revealed that the ethyl ester group in 226068-82-2 provides an excellent balance between lipophilicity and metabolic stability, making it particularly valuable in CNS drug discovery. Recent molecular modeling analyses suggest the compound's potential for developing allosteric modulators of G-protein coupled receptors (GPCRs), with several patent applications filed in early 2024.

Ongoing clinical trials (Phase I/II) are investigating derivatives of Ethyl 2-(piperazin-2-yl)acetate as potential treatments for neurodegenerative diseases, with preliminary results showing promising neuroprotective effects in cellular and animal models of Parkinson's disease. The compound's ability to chelate metal ions may contribute to its observed antioxidant properties in these studies.

From a synthetic chemistry perspective, recent advances in catalytic asymmetric synthesis have enabled more efficient production of enantiomerically pure Ethyl 2-(piperazin-2-yl)acetate, addressing previous challenges in stereochemical control. This development has significant implications for the compound's use in chiral drug synthesis.

Future research directions include exploring the compound's potential in targeted drug delivery systems and as a component of PROTACs (proteolysis targeting chimeras) for protein degradation therapies. The unique structural features of 226068-82-2 continue to make it a valuable tool in modern drug discovery and chemical biology research.

• 368441-98-9(methyl 2-piperazin-2-ylacetate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)