• 1. Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core
  Mohamed Salah,Mohammad Abdel-Halim,Matthias Engel Med. Chem. Commun. 2018 9 1045

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetamides

Comprehensive Overview of 2-(3-Hydroxyphenyl)acetamide (CAS No. 22446-41-9): Properties, Applications, and Research Insights

2-(3-Hydroxyphenyl)acetamide (CAS No. 22446-41-9) is a bioactive organic compound with a molecular formula of C₈H₉NO₂. This hydroxyphenyl derivative has garnered significant attention in pharmaceutical and biochemical research due to its potential as a precursor or intermediate in drug synthesis. Its structural features, including a phenolic hydroxyl group and an acetamide moiety, make it a versatile building block for designing molecules with targeted biological activities.

In recent years, the demand for specialty chemicals like 2-(3-Hydroxyphenyl)acetamide has surged, driven by advancements in drug discovery and personalized medicine. Researchers frequently explore its role in synthesizing neuroprotective agents or anti-inflammatory compounds, aligning with trends in aging population healthcare and chronic disease management. The compound’s CAS number 22446-41-9 serves as a critical identifier in regulatory documentation and patent filings.

The synthesis of 2-(3-Hydroxyphenyl)acetamide typically involves amidation reactions or enzymatic catalysis, reflecting the growing preference for green chemistry methods. Analytical techniques such as HPLC and NMR spectroscopy are employed to verify its purity, a topic frequently queried in scientific forums and academic databases. Its solubility in polar solvents like DMSO and ethanol further enhances its utility in lab-scale formulations.

From an industrial perspective, CAS 22446-41-9 is often discussed in contexts like scale-up challenges and cost-effective production. These keywords resonate with process chemists and supply chain managers seeking to optimize batch consistency. Additionally, its stability under controlled storage conditions (e.g., inert atmospheres) is a recurring theme in material safety data sheets (MSDS).

Emerging applications of 2-(3-Hydroxyphenyl)acetamide include its exploration in cosmeceuticals, where its antioxidant properties are studied for skincare formulations. This aligns with the booming clean beauty movement and consumer interest in science-backed ingredients. Patent analyses reveal its inclusion in topical delivery systems, addressing queries about its dermal absorption and biocompatibility.

Environmental and regulatory aspects of 22446-41-9 are also pivotal. The compound’s biodegradability profile and eco-toxicity data are increasingly scrutinized under REACH compliance frameworks. Such discussions cater to ESG-driven industries and sustainability-focused research initiatives.

In summary, 2-(3-Hydroxyphenyl)acetamide exemplifies the intersection of medicinal chemistry and industrial innovation. Its multifaceted applications—from pharmaceutical intermediates to cosmetic actives—underscore its relevance in both academic and commercial spheres. Ongoing studies continue to unravel its potential, making CAS No. 22446-41-9 a compound of enduring scientific interest.

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