Cas no 22395-22-8 (7-Methoxyflavone)
7-Methoxyflavone Chemical and Physical Properties
Names and Identifiers
-
- 7-Methoxy-2-phenyl-4H-chromen-4-one
- 7-methoxy-2-phenylchromen-4-one
- 7-METHOXYFLAVONE
- METHOXYFLAVONE, 7-(RG)
- 7-methoxoyflavone
- 7-methoxy-2-phenyl-4H-1-benzopyran-4-one
- 7-methoxy-2-phenyl-chromen-4-one
- 8-methoxyflavone
- METHOXYFLAVONE,7
- 7-Methoxy-2-phenyl-4H-benzopyran-4-one
- Oprea1_076281
- CHEMBL16782
- F3385-6145
- BDBM50591918
- HY-N8487
- DTXSID80332790
- 7-Methoxy-2-phenylchromone
- LMPK12110021
- MFCD00017462
- SR-01000434441
- SR-01000434441-1
- J-014687
- FT-0698081
- CS-0144725
- XK561AP5UR
- NCGC00180781-02
- 7-Methoxy Flavone
- UNII-XK561AP5UR
- NSC 741744
- BRD-K00654887-001-01-5
- MEGxp0_001706
- PD143277
- SCHEMBL1373009
- EU-0071703
- NSC-741744
- NCGC00180781-01
- InChI=1/C16H12O3/c1-18-12-7-8-13-14(17)10-15(19-16(13)9-12)11-5-3-2-4-6-11/h2-10H,1H
- Flavone, 7-methoxy-
- D70148
- M1423
- NS00015828
- FT-0638222
- 7-METHOXYFLAVONE [VANDF]
- AKOS001617181
- CCG-106707
- BIDD:ER0421
- A1-00200
- Q27293878
- 22395-22-8
- ACon1_000207
- CHEBI:192603
- DS-4825
- NSC741744
- 4H-1-Benzopyran-4-one, 7-methoxy-2-phenyl-
- MB00278
- A878550
- AB00133543-03
- DB-045897
- STL100263
- 7-Methoxyflavone
-
- MDL： MFCD00017462
- Inchi： 1S/C16H12O3/c1-18-12-7-8-13-14(17)10-15(19-16(13)9-12)11-5-3-2-4-6-11/h2-10H,1H3
- InChI Key： QKNDCRMJDZLFEG-UHFFFAOYSA-N
- SMILES： O1C(=CC(C2C=CC(=CC1=2)OC)=O)C1C=CC=CC=1
Computed Properties
- Exact Mass: 252.07900
- Monoisotopic Mass: 252.078644
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 19
- Rotatable Bond Count: 2
- Complexity: 368
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
- Topological Polar Surface Area: 35.5
Experimental Properties
- Color/Form: Undetermined 2. density (g/ml, 25/4 ℃)
- Density: 1.240±0.06 g/cm3 (20 oC 760 Torr),
- Melting Point: 109.0 to 113.0 deg-C
- Boiling Point: 421.2±45.0 °C at 760 mmHg
- Flash Point: 200.3±15.1 °C
- Solubility: Almost insoluble (0.012 g/l) (25 o C),
- PSA: 39.44000
- LogP: 3.46860
7-Methoxyflavone Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - WGK Germany：3
- Safety Instruction： 24/25
- Storage Condition：Store at 4°C,-4At ℃Store…Better
7-Methoxyflavone Customs Data
- HS CODE：2932999099
- Customs Data：
China Customs Code:
2914509090Overview:
2914509090 Ketones containing other oxygen-containing groups. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%
Declaration elements:
Product Name, component content, use to, Acetone declared packaging
Summary:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
7-Methoxyflavone Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A019109185-100g |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 98% | 100g |
$303.00 | 2023-09-02 | |
| Chemenu | CM162439-25g |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 95+% | 25g |
$102 | 2021-08-05 | |
| Chemenu | CM162439-100g |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 95+% | 100g |
$281 | 2021-08-05 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | M843230-25g |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 98% | 25g |
1,016.00 | 2021-05-17 | |
| TRC | M350288-250mg |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 250mg |
$ 50.00 | 2022-06-03 | ||
| TRC | M350288-500mg |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 500mg |
$ 65.00 | 2022-06-03 | ||
| TRC | M350288-2.5g |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 2.5g |
$ 115.00 | 2022-06-03 | ||
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | M38950-1g |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 98% | 1g |
￥58.0 | 2022-04-27 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | M38950-100g |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 98% | 100g |
￥1778.0 | 2022-04-27 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | M38950-5g |
7-Methoxy-2-phenyl-4H-chromen-4-one |
22395-22-8 | 98% | 5g |
￥178.0 | 2022-04-27 |
7-Methoxyflavone Suppliers
Audited Supplier
Audited Supplier
7-Methoxyflavone Related Literature
-
Rui Wang,Jie Han,Chenchen Li,Jie Zhang,Yong Liang,Tao Wang,Zunting Zhang Org. Biomol. Chem. 2018 16 2479
-
Jun Lee,Jihyun Yu,Seung Hwan Son,Jinyuk Heo,Taelim Kim,Ji-Young An,Kyung-Soo Inn,Nam-Jung Kim Org. Biomol. Chem. 2016 14 777
-
Narender Goel,Rahul L. Gajbhiye,Moumita Saha,Chennuru Nagendra,Araveeti Madhusudhana Reddy,V. Ravichandiran,Krishna Das Saha,Parasuraman Jaisankar RSC Adv. 2021 11 35918
-
Nigel C. Veitch,Renée J. Grayer Nat. Prod. Rep. 2011 28 1626
-
Ningbo Gong,Kun Hu,Guimin Jin,Guanhua Du,Yang Lu RSC Adv. 2016 6 38709
Additional information on 7-Methoxyflavone
7-Methoxyflavone (CAS No: 22395-22-8) - A Comprehensive Overview of Its Applications and Research
7-Methoxyflavone, chemically designated as 7-Methoxyflavone, is a naturally occurring flavonoid with the molecular formula C15H10O4. It is identified by the CAS number CAS No: 22395-22-8 and has garnered significant attention in the field of pharmaceutical research due to its diverse biological activities. Flavonoids are a class of polyphenolic compounds widely distributed in plants, and 7-Methoxyflavone is particularly noted for its potential therapeutic properties.
The structural characteristics of 7-Methoxyflavone include a flavone backbone with a methoxy group at the 7-position, which contributes to its unique chemical properties and biological interactions. This compound has been extensively studied for its antioxidant, anti-inflammatory, and anticancer effects. The presence of the methoxy group enhances its stability and bioavailability, making it an attractive candidate for further development in drug discovery.
In recent years, the interest in 7-Methoxyflavone has been fueled by its promising applications in oncology. Research has demonstrated that it can induce apoptosis in various cancer cell lines by modulating multiple signaling pathways. For instance, studies have shown that 7-Methoxyflavone can inhibit the activity of kinases such as Akt and Erk, which are crucial for cancer cell survival and proliferation. Additionally, it has been observed to suppress the expression of anti-apoptotic proteins like Bcl-2, thereby promoting cancer cell death.
Beyond its role in cancer research, 7-Methoxyflavone has also been investigated for its potential in neuroprotection. Oxidative stress and inflammation are key factors in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's. Preclinical studies have indicated that 7-Methoxyflavone can mitigate oxidative damage by scavenging free radicals and inhibiting inflammatory responses. Its ability to cross the blood-brain barrier further enhances its potential as a therapeutic agent for neurological disorders.
The anti-inflammatory properties of 7-Methoxyflavone have also been explored in the context of chronic inflammatory diseases. By inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6, this compound can help regulate immune responses and reduce inflammation. This makes it a promising candidate for treating conditions like rheumatoid arthritis and inflammatory bowel disease.
In addition to its biological activities, 7-Methoxyflavone exhibits notable pharmacokinetic properties. Its solubility in both water and lipids allows for versatile formulation options, enhancing its bioavailability. Furthermore, its stability under various conditions makes it suitable for oral administration and topical applications. These attributes are critical for developing effective pharmaceutical formulations that can be easily administered to patients.
The synthesis of 7-Methoxyflavone can be achieved through various chemical pathways, including natural extraction from plant sources or synthetic methods. Natural sources rich in this flavonoid include certain species of plants such as those belonging to the genus Polygonum. However, synthetic production offers greater control over purity and yield, making it more feasible for industrial applications.
The safety profile of 7-Methoxyflavone has been assessed through preclinical studies, which have generally reported low toxicity at therapeutic doses. However, further research is needed to fully understand its long-term effects and potential side effects. Clinical trials are currently underway to evaluate its efficacy and safety in humans for various therapeutic indications.
The future prospects of 7-Methoxyflavone in pharmaceutical development are promising. Ongoing research aims to optimize its delivery systems and explore novel therapeutic applications. By leveraging advanced technologies such as nanotechnology and targeted drug delivery systems, scientists hope to enhance the efficacy of 7-Methoxyflavone-based therapies.
In conclusion, 7-Methoxyflavone (CAS No: 22395-22-8) is a versatile flavonoid with significant potential in pharmaceutical applications. Its diverse biological activities, coupled with favorable pharmacokinetic properties, make it an attractive candidate for drug development. As research continues to uncover new insights into its mechanisms of action and therapeutic benefits, 7-Methoxyflavone is poised to play a crucial role in the next generation of medicinal chemistry.
