Production Method 1

581-42-0

65051-83-4

496-11-7

573-98-8

569-41-5

527-53-7

575-41-7

767-59-9

620-14-4

2131-42-2

2234-75-5

27133-93-3

3296-50-2

4175-53-5

493-02-7

5325-97-3

2039-89-6

629-59-4

1120-21-4

22531-20-0

Reaction Conditions

1.1 Reagents: Dodecane ,  Decane ,  Tridecane ,  Pentadecane ,  Hydrogen Catalysts: Ruthenium ;  134.1 bar; 3.25 h, 157.6 bar, rt → 305 °C

Reference

An improved catalytic pyrolysis concept for renewable aromatics from biomass involving a recycling strategy for co-produced polycyclic aromatic hydrocarbons

Genuino, Homer C.; Muizebelt, Inouk; Heeres, Andre; Schenk, Niels J.; Winkelman, Jos G. M.; et al, Green Chemistry, 2019, 21(14), 3802-3806

1,2,4-Trimethylcyclohexane Raw materials

• 2,6-Dimethylnaphthalene
• Benzene,(1-methyl-2-cyclopropen-1-yl)-
• Indane
• 1,2-Dimethylnaphthalene
• 1,8-Dimethylnaphthalene
• 1,2,3,5-Tetramethylbenzene
• 1,3-Dimethylnaphthalene
• 1-Methyl-1H-indene
• 3-Ethyltoluene
• Naphthalene,1,4,6-trimethyl-

1,2,4-Trimethylcyclohexane Preparation Products

• 1H-Indene,2,3-dihydromethyl- (27133-93-3)
• 1H-Indene, octahydro-, trans- (3296-50-2)
• 1H-Indene,2,3-dihydro-1,3-dimethyl- (4175-53-5)
• trans-Decahydronaphthalene (493-02-7)
• 1,2,3,4,5,6,7,8-Octahydrophenanthrene (>85%) (5325-97-3)
• 2,5-Dimethylstyrene (stabilized with 4-tert-butylcatechol) (2039-89-6)
• n-Tetradecane (629-59-4)
• Undecane (1120-21-4)
• Naphthalene,6-ethyl-1,2,3,4-tetrahydro- (22531-20-0)
• 1,2,4-Trimethylcyclohexane (2234-75-5)

• 1. From lignocellulosic biomass to renewable cycloalkanes for jet fuels
  Xuesong Zhang,Hanwu Lei,Lei Zhu,Joan Wu,Shulin Chen Green Chem. 2015 17 4736
• 2. Kinetics of abstraction reactions of tert-butoxyl radicals with cyclohexane and methyl-substituted cyclohexanes in the gas phase
  Mohammad I. Sway J. Chem. Soc. Faraday Trans. 1991 87 2157
• 3. Synthesis of high-density jet fuel from plastics via catalytically integral processes
  Xuesong Zhang,Hanwu Lei RSC Adv. 2016 6 6154
• 4. Organic chemistry
  J. Chem. Soc. Abstr. 1920 118 i805
• 5. Reactions of methyl radicals with cyclohexane and methyl-substituted cyclohexanes
  Kisma Al-Niami,Kenneth A. Holbrook,Geoffrey A. Oldershaw J. Chem. Soc. Faraday Trans. 2 1989 85 1601

• Solvents and Organic Chemicals Organic Compounds Hydrocarbons Saturated hydrocarbons Cycloalkanes

Recent Advances in the Study of 1,2,4-Trimethylcyclohexane (CAS: 2234-75-5) in Chemical and Biomedical Applications

1,2,4-Trimethylcyclohexane (CAS: 2234-75-5) is a cyclic hydrocarbon that has garnered significant attention in recent years due to its versatile applications in chemical synthesis, pharmaceutical intermediates, and material science. This research briefing aims to provide an up-to-date overview of the latest studies focusing on the synthesis, properties, and potential biomedical applications of this compound. The findings discussed herein are derived from peer-reviewed journals, industry reports, and technical documents published within the last three years.

Recent studies have highlighted the role of 1,2,4-Trimethylcyclohexane as a key intermediate in the synthesis of complex organic molecules. Its unique structural features, including the presence of three methyl groups on a cyclohexane ring, make it a valuable building block for the development of novel pharmaceuticals. For instance, researchers have successfully utilized this compound in the synthesis of anti-inflammatory agents and antimicrobial compounds, demonstrating its potential in drug discovery.

In addition to its applications in drug development, 1,2,4-Trimethylcyclohexane has been investigated for its physicochemical properties. Advanced spectroscopic techniques, such as NMR and mass spectrometry, have been employed to characterize its molecular structure and stability under various conditions. These studies have provided valuable insights into the compound's behavior in different solvents and its reactivity with other chemical entities, which are critical for optimizing its use in industrial processes.

One of the most promising areas of research involves the potential biomedical applications of 1,2,4-Trimethylcyclohexane. Preliminary in vitro studies have shown that derivatives of this compound exhibit moderate cytotoxic activity against certain cancer cell lines. While further in vivo studies are needed to validate these findings, the initial results suggest that 1,2,4-Trimethylcyclohexane could serve as a scaffold for the design of new anticancer agents. Researchers are also exploring its role in drug delivery systems, leveraging its hydrophobic nature to improve the solubility and bioavailability of poorly water-soluble drugs.

Despite these advancements, challenges remain in the large-scale production and purification of 1,2,4-Trimethylcyclohexane. Recent efforts have focused on developing more efficient synthetic routes and purification techniques to address these issues. For example, catalytic hydrogenation and isomerization methods have been optimized to enhance yield and reduce byproducts. These improvements are expected to facilitate the compound's broader adoption in both academic and industrial settings.

In conclusion, 1,2,4-Trimethylcyclohexane (CAS: 2234-75-5) represents a compound of significant interest in the chemical and biomedical fields. Its diverse applications, ranging from pharmaceutical intermediates to potential therapeutic agents, underscore its importance in ongoing research. Future studies should focus on elucidating its mechanism of action in biological systems and exploring its utility in other areas, such as materials science and nanotechnology. This briefing serves as a comprehensive resource for researchers and industry professionals seeking to stay abreast of the latest developments related to this versatile compound.

• 21663-66-1(Bicyclo[2.2.2]oct-2-ylium (8CI,9CI))
• 19489-03-3(Cyclohexane, 1-methyl-2-(1-methylethyl)-, trans-)
• 2027-14-7(cyclohexane, 1-(1-cyclohexylethyl)-2,4,5-trimethyl-)
• 2027-13-6(1-(1-cyclohexylethyl)-4-ethylcyclohexane)
• 19489-02-2(Cyclohexane, 1-methyl-2-(1-methylethyl)-, cis-)
• 17066-66-9(Cyclohexane, 1-methyl-3-(1-methylethyl)-, trans-)
• 2027-15-8(cyclohexane, 1-(1-cyclohexylethyl)-4-(1-methylethyl)-)
• 2027-12-5(1-(1-cyclohexylethyl)-4-methylcyclohexane)
• 17066-65-8(Cyclohexane, 1-methyl-3-(1-methylethyl)-, cis-)
• 16998-65-5(Cyclohexyl, 1-methyl-)