• 1. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
• 2. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 3. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 4. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 5. An analyte-triggered artificial peroxidase system based on dimanganese complex for a versatile enzyme assay?
  Suji Lee,Min Su Han Chem. Commun., 2021,57, 9450-9453

Recent Advances in the Study of N-(3-ethynylphenyl)methylhydroxylamine (CAS: 2228390-50-7)

The compound N-(3-ethynylphenyl)methylhydroxylamine (CAS: 2228390-50-7) has recently garnered significant attention in the field of chemical biology and medicinal chemistry due to its unique structural properties and potential therapeutic applications. This research brief aims to provide an overview of the latest findings related to this compound, focusing on its synthesis, biological activity, and potential as a drug candidate. The information presented herein is derived from peer-reviewed publications, patent filings, and industry reports published within the last two years.

Recent studies have highlighted the role of N-(3-ethynylphenyl)methylhydroxylamine as a versatile building block in the synthesis of novel bioactive molecules. Its ethynyl and hydroxylamine functional groups make it particularly useful for click chemistry applications, enabling the rapid assembly of complex molecular architectures. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy in forming stable conjugates with various biomolecules, suggesting potential applications in targeted drug delivery systems.

In terms of biological activity, preliminary in vitro studies have shown that N-(3-ethynylphenyl)methylhydroxylamine exhibits moderate inhibitory effects against certain enzymes involved in inflammatory pathways. Researchers at a leading pharmaceutical company have reported its potential as a lead compound for developing new anti-inflammatory agents, with ongoing optimization studies aiming to improve its pharmacokinetic properties. The compound's ability to modulate specific protein-protein interactions is currently under investigation in several academic laboratories.

The safety profile of N-(3-ethynylphenyl)methylhydroxylamine has been evaluated in recent preclinical studies. While generally showing good tolerability in cellular assays, some reports indicate the need for careful consideration of dosage levels due to potential reactive oxygen species generation at higher concentrations. These findings underscore the importance of structural modifications to enhance the compound's therapeutic index while minimizing off-target effects.

Looking forward, the most promising applications of N-(3-ethynylphenyl)methylhydroxylamine appear to be in the areas of targeted cancer therapies and neurodegenerative disease treatment. Its ability to cross the blood-brain barrier, as demonstrated in recent animal studies, makes it particularly interesting for central nervous system drug development. Several research groups are currently exploring its incorporation into PROTAC (proteolysis targeting chimera) molecules for targeted protein degradation applications.

In conclusion, N-(3-ethynylphenyl)methylhydroxylamine represents an exciting area of research in chemical biology and drug discovery. While significant progress has been made in understanding its properties and potential applications, further studies are needed to fully realize its therapeutic potential. The coming years are likely to see increased research activity around this compound as its versatility and biological relevance become more apparent to the scientific community.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)