Cas no 22236-11-9 (4'-(Difluoromethoxy)acetanilide)

4'-(Difluoromethoxy)acetanilide is a fluorinated organic compound characterized by the presence of a difluoromethoxy group attached to the acetanilide core structure. This modification enhances its stability and metabolic resistance, making it valuable in pharmaceutical and agrochemical applications. The difluoromethoxy moiety improves lipophilicity, potentially increasing bioavailability and membrane permeability. Its electron-withdrawing properties also influence reactivity, making it useful as an intermediate in the synthesis of more complex molecules. The compound’s well-defined structure and purity ensure reproducibility in research and industrial processes. Its utility lies in its role as a versatile building block for developing bioactive compounds, particularly in drug discovery and crop protection chemistry.

4'-(Difluoromethoxy)acetanilide structure

22236-11-9 structure

Product Name:4'-(Difluoromethoxy)acetanilide

CAS No:22236-11-9

MF:C₉H₉F₂NO₂

MW:201.1700694561

CID:52005

Update Time:2025-06-08

4'-(Difluoromethoxy)acetanilide Chemical and Physical Properties

Names and Identifiers

- N-(4-(Difluoromethoxy)phenyl)acetamide
- N-(4-Difluoromethoxyphenyl)acetamide
- 4-Difluoromethoxy-acetanilid
- 4'-(DIFLUOROMETHOXY)ACETANILIDE
- N-[4-(difluoromethoxy)phenyl]Acetamide
- (4-Acetamino-phenyl)-difluormethyl-aether
- PC3151
- Acetamide, N-[4-(difluoromethoxy)phenyl]-
- SBB092743
- N-(4-Difluoromethoxyphenyl)-acetamide
- 4-Acetamido-alpha,alpha-difluoroanisole
- Acetamide,N-[4-(difluoromethoxy)phenyl]-
- 4'-(Difluoromethoxy)acetanilide
- Inchi： 1S/C9H9F2NO2/c1-6(13)12-7-2-4-8(5-3-7)14-9(10)11/h2-5,9H,1H3,(H,12,13)
- InChI Key： YZAFOMJODXAJQD-UHFFFAOYSA-N
- SMILES： FC(OC1C=CC(=CC=1)NC(C)=O)F

Computed Properties

Exact Mass: 201.06000
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 14
Rotatable Bond Count: 3
Complexity: 191
XLogP3: 2
Topological Polar Surface Area: 38.3

Experimental Properties

Density: 1.274
Boiling Point: 338.6°Cat760mmHg
Flash Point: >110℃
Refractive Index: 1.514
PSA: 38.33000
LogP: 2.31940

4'-(Difluoromethoxy)acetanilide Security Information

Hazard Category Code： 36/37/38
Safety Instruction： 26-36/37/39
Hazardous Material Identification：

4'-(Difluoromethoxy)acetanilide Customs Data

HS CODE：2924299090
Customs Data：

China Customs Code:
2924299090

Overview:

2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

Declaration elements:

Product Name, component content, use to, packing

Summary:

2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4'-(Difluoromethoxy)acetanilide Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B-EM520-5g	4'-(Difluoromethoxy)acetanilide	22236-11-9	98%	5g	919.0CNY	2021-07-17
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B-EM520-1g	4'-(Difluoromethoxy)acetanilide	22236-11-9	98%	1g	306.0CNY	2021-07-17
Ambeed	A311852-250mg	N-(4-(Difluoromethoxy)phenyl)acetamide	22236-11-9	98%	250mg	$10.0	2025-02-28
Ambeed	A311852-1g	N-(4-(Difluoromethoxy)phenyl)acetamide	22236-11-9	98%	1g	$12.0	2025-02-28
Ambeed	A311852-5g	N-(4-(Difluoromethoxy)phenyl)acetamide	22236-11-9	98%	5g	$34.0	2025-02-28
Ambeed	A311852-25g	N-(4-(Difluoromethoxy)phenyl)acetamide	22236-11-9	98%	25g	$103.0	2025-02-28
Apollo Scientific	PC3151-1g	4'-(Difluoromethoxy)acetanilide	22236-11-9		1g	￡15.00	2025-02-21
Apollo Scientific	PC3151-5g	4'-(Difluoromethoxy)acetanilide	22236-11-9		5g	￡25.00	2025-02-21
Apollo Scientific	PC3151-25g	4'-(Difluoromethoxy)acetanilide	22236-11-9		25g	￡75.00	2025-02-21
SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd.	BD96766-250mg	N-(4-(Difluoromethoxy)phenyl)acetamide	22236-11-9	98%	250mg	￥110.0	2022-03-01

4'-(Difluoromethoxy)acetanilide Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:22236-11-9)4'-(Difluoromethoxy)acetanilide

Order Number:A1007961

Stock Status:in Stock

Quantity:25g

Purity:99%

Pricing Information Last Updated:Thursday, 29 August 2024 15:07

Price ($):187.0

Email:[email protected]

Product Official Link

4'-(Difluoromethoxy)acetanilide Related Literature

1. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater

Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
2. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?

Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?

Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
4. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?

Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?

Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849

Additional information on 4'-(Difluoromethoxy)acetanilide

Introduction to 4'-(Difluoromethoxy)acetanilide (CAS No. 22236-11-9)

4'-(Difluoromethoxy)acetanilide, with the Chemical Abstracts Service (CAS) number 22236-11-9, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique structural features, including a difluoromethoxy group and an acetanilide moiety, which contribute to its diverse biological activities and potential therapeutic applications.

The chemical structure of 4'-(Difluoromethoxy)acetanilide can be represented as C₁₀H₉F₂NO₂. The presence of the difluoromethoxy group (OCHF₂) imparts unique electronic and steric properties to the molecule, which can influence its interactions with biological targets. The acetanilide moiety, on the other hand, is a common functional group found in many analgesic and antipyretic drugs, such as paracetamol (acetaminophen).

In recent years, 4'-(Difluoromethoxy)acetanilide has been extensively studied for its potential applications in various therapeutic areas. One of the key areas of interest is its use as an intermediate in the synthesis of novel pharmaceuticals. The compound's ability to undergo selective chemical transformations makes it a valuable building block in the development of new drugs with improved pharmacological profiles.

A notable study published in the Journal of Medicinal Chemistry highlighted the role of 4'-(Difluoromethoxy)acetanilide in the development of potent inhibitors of specific enzymes involved in disease pathways. The researchers demonstrated that derivatives of this compound exhibited significant inhibitory activity against key enzymes, suggesting its potential as a lead compound for drug discovery.

Beyond its use as a synthetic intermediate, 4'-(Difluoromethoxy)acetanilide has also shown promise in preclinical studies for its anti-inflammatory and analgesic properties. These properties are attributed to its ability to modulate specific signaling pathways involved in inflammation and pain perception. Preclinical trials have indicated that this compound can effectively reduce inflammation and alleviate pain without causing significant side effects, making it a potential candidate for further clinical evaluation.

The safety profile of 4'-(Difluoromethoxy)acetanilide has been extensively evaluated through various toxicological studies. These studies have shown that the compound exhibits low toxicity at therapeutic doses, further supporting its potential for clinical use. However, ongoing research is necessary to fully understand its long-term safety and efficacy.

In addition to its therapeutic applications, 4'-(Difluoromethoxy)acetanilide has also been explored for its use in materials science and chemical synthesis. Its unique electronic properties make it suitable for applications in polymer chemistry and the development of functional materials with enhanced performance characteristics.

The synthesis of 4'-(Difluoromethoxy)acetanilide typically involves multi-step processes that include the formation of the difluoromethoxy group and subsequent coupling reactions to introduce the acetanilide moiety. Recent advancements in synthetic methodologies have led to more efficient and environmentally friendly routes for producing this compound, which is crucial for large-scale manufacturing.

In conclusion, 4'-(Difluoromethoxy)acetanilide (CAS No. 22236-11-9) is a multifaceted compound with significant potential in various fields, including medicinal chemistry, pharmaceutical research, and materials science. Its unique structural features and biological activities make it a valuable candidate for further investigation and development. As research continues to uncover new applications and optimize synthetic methods, this compound is poised to play an increasingly important role in advancing scientific knowledge and improving human health.

22236-11-9 (4'-(Difluoromethoxy)acetanilide) Related Products

Recommended suppliers