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Comprehensive Guide to Acetamide,N-[4-(4-aminophenoxy)phenyl]- (CAS 2687-41-4): Properties, Applications, and Market Insights

Acetamide,N-[4-(4-aminophenoxy)phenyl]- (CAS 2687-41-4) is a specialized organic compound gaining attention in pharmaceutical intermediates and advanced material synthesis. This aromatic acetamide derivative features a unique molecular structure combining phenoxy and amino functional groups, making it valuable for creating heat-resistant polymers and drug precursors. Researchers frequently search for "Acetamide,N-[4-(4-aminophenoxy)phenyl]- synthesis" and "CAS 2687-41-4 applications," reflecting growing interest in its versatile chemistry.

The compound's molecular formula C14H14N2O2 reveals a molecular weight of 242.28 g/mol, with its aminophenoxy-phenyl backbone contributing to exceptional thermal stability (decomposition point >300°C). Recent studies highlight its role as a key intermediate for polyimide precursors, addressing the industry demand for high-performance polymers in flexible electronics. Questions like "how to purify Acetamide,N-[4-(4-aminophenoxy)phenyl]-" frequently appear in chemical forums, indicating practical challenges in handling this crystalline solid.

In pharmaceutical applications, this acetamide derivative serves as a building block for targeted drug delivery systems, particularly in oncology research. Its ability to form hydrogen bonds makes it valuable for designing enzyme inhibitors, with patent literature showing utility in kinase modulation. The search term "CAS 2687-41-4 solubility" yields numerous technical inquiries, as researchers explore its behavior in polar aprotic solvents like DMF and DMSO.

The global market for specialty acetamide compounds is projected to grow at 6.2% CAGR through 2030, driven by demand from Asia-Pacific electronics manufacturers. Environmental considerations have spurred interest in "green synthesis of Acetamide,N-[4-(4-aminophenoxy)phenyl]-," with recent publications demonstrating catalytic methods reducing byproduct formation. Analytical challenges remain, as evidenced by frequent searches for "HPLC methods for CAS 2687-41-4" and "spectral data of aromatic acetamides."

Quality standards for Acetamide,N-[4-(4-aminophenoxy)phenyl]- typically require ≥98% purity, with advanced grades reaching 99.5% for electronic applications. The compound's dual functionality (amide + amine) enables diverse derivatization pathways, making it valuable for combinatorial chemistry. Emerging research explores its potential in organic semiconductors, particularly for perovskite solar cell components, answering industry queries about "conductive polymers from acetamide precursors."

Storage recommendations for this light-sensitive compound emphasize amber glass containers under inert atmosphere, with technical discussions often focusing on "stability of CAS 2687-41-4" under various conditions. The European Chemicals Agency (ECHA) registration data confirms its commercial availability through specialty chemical suppliers, though synthesis scale-up remains an active research area. Recent process optimization studies have improved yields from 68% to 89% in pilot-scale productions.

Spectroscopic characterization of Acetamide,N-[4-(4-aminophenoxy)phenyl]- reveals distinctive IR absorptions at 1650 cm?1 (C=O stretch) and 3350 cm?1 (N-H stretch), with ¹H NMR showing characteristic aromatic patterns. These analytical signatures help address common identification challenges noted in "CAS 2687-41-4 characterization" searches. The compound's low acute toxicity profile (LD50 >2000 mg/kg in rodents) supports its safe handling in controlled environments.

Future research directions include exploring microwave-assisted synthesis routes and developing water-soluble derivatives for biomedical applications. The compound's structure-activity relationships continue to interest medicinal chemists, particularly in designing selective receptor modulators. With tightening regulations on persistent organic pollutants, the biodegradability of acetamide derivatives has become a key research focus, reflected in increasing publications since 2020.

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