Production Method 1

612-75-9

613-33-2

611-61-0

611-43-8

222180-19-0

222180-23-6

147404-69-1

70916-98-2

606-80-4

720-73-0

5728-33-6

222180-20-3

216443-78-6

400744-83-4

116470-54-3

92152-01-7

36393-42-7

158619-46-6

787-70-2

612-87-3

Reaction Conditions

1.1 Catalysts: Cobalt diacetate Solvents: Acetic acid ;  2 h, 500 psi, 130 °C

Reference

A process for selective aerobic oxidation of dimethylbiphenyl derivatives

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3'-Formylbiphenyl-3-carboxylic acid Raw materials

• 3,3'-Dimethylbiphenyl
• 4,4'-Bitoluene
• 2,4'-Dimethylbiphenyl
• 2,3'-Dimethylbiphenyl

3'-Formylbiphenyl-3-carboxylic acid Preparation Products

• 4-(3-Formylphenyl)benzoic Acid (222180-23-6)
• 4'-Methylbiphenyl-3-carboxylic acid (147404-69-1)
• 4-(4-Formylphenyl)benzoic acid (70916-98-2)
• 2-(4-Carboxyphenyl)benzoic acid (606-80-4)
• 4'-methyl-1,1'-biphenyl-4-carboxylic acid (720-73-0)
• 3'-Methyl1,1'-biphenyl-4-carboxylic Acid (5728-33-6)
• 4'-Formyl-1,1'-biphenyl-3-carboxylic Acid (222180-20-3)
• 3'-Methyl-1,1'-biphenyl-3-carbaldehyde (216443-78-6)
• 3'-methyl-[1,1'-biphenyl]-4-carbaldehyde (400744-83-4)
• 4'-Methylbiphenyl-3-carbaldehyde (116470-54-3)
• Biphenyl-3,4'-dicarboxylic acid (92152-01-7)
• 4'-methyl-1,1'-biphenyl-4-carbaldehyde (36393-42-7)
• 3'-Formylbiphenyl-3-carboxylic acid (222180-19-0)
• 3'-Methylbiphenyl-3-carboxylic acid (158619-46-6)
• 1,1'-Biphenyl-4,4'-dicarboxylic Acid (787-70-2)
• 3,3'-H2BPDC (612-87-3)

• 1. Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay
  Zhongjie Liang,Xiao Ding,Jing Ai,Xiangqian Kong,Limin Chen,Liang Chen,Cheng Luo,Meiyu Geng,Hong Liu,Kaixian Chen,Hualiang Jiang Org. Biomol. Chem. 2012 10 421

Comprehensive Overview of 3'-Formylbiphenyl-3-carboxylic acid (CAS No. 222180-19-0): Properties, Applications, and Industry Insights

3'-Formylbiphenyl-3-carboxylic acid (CAS No. 222180-19-0) is a high-value organic compound widely utilized in pharmaceutical intermediates, material science, and specialty chemical synthesis. Its unique molecular structure, featuring both a formyl group and a carboxylic acid moiety, enables versatile reactivity, making it a critical building block for advanced research and industrial applications. This article delves into its chemical properties, synthesis pathways, and emerging trends aligned with current scientific and commercial demands.

The compound’s biphenyl backbone provides structural rigidity, while the 3'-formyl and 3-carboxylic acid functional groups offer sites for further derivatization. Researchers frequently employ 3'-Formylbiphenyl-3-carboxylic acid in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, to construct complex molecules for drug discovery. Recent studies highlight its role in developing fluorescent probes and organic electronic materials, addressing growing interest in sustainable technologies and optoelectronics.

From an industrial perspective, the demand for CAS 222180-19-0 has surged due to its applications in high-performance polymers and liquid crystal displays (LCDs). Manufacturers prioritize scalable synthesis methods to meet the needs of sectors like renewable energy and biomedical devices. Innovations in green chemistry have also driven the adoption of catalytic processes to produce this compound with minimal environmental impact, resonating with global sustainability goals.

Analytical techniques such as HPLC, NMR, and mass spectrometry are essential for verifying the purity of 3'-Formylbiphenyl-3-carboxylic acid, ensuring compliance with regulatory standards. FAQs from academic and industrial circles often focus on its solubility (e.g., in DMSO or ethanol), storage conditions (typically 2–8°C under inert gas), and compatibility with common reagents. These practical considerations are critical for laboratory safety and process optimization.

Emerging trends link CAS 222180-19-0 to cutting-edge fields like metal-organic frameworks (MOFs) and bioconjugation. Its bifunctional nature allows integration into hybrid materials for gas storage or targeted drug delivery systems. As AI-driven molecular design gains traction, this compound’s data-rich profile supports machine learning models predicting novel applications, aligning with the digital transformation of chemical R&D.

In summary, 3'-Formylbiphenyl-3-carboxylic acid exemplifies the intersection of traditional organic chemistry and modern technological needs. Its adaptability across disciplines—from pharmaceuticals to nanomaterials—positions it as a compound of enduring relevance. Future research may explore its potential in bioimaging or catalysis, further expanding its commercial and scientific footprint.

• 13653-84-4(H2TPDC)
• 13215-72-0(H2MDCPB)
• 147404-69-1(4'-Methylbiphenyl-3-carboxylic acid)
• 70916-98-2(4-(4-Formylphenyl)benzoic acid)
• 773872-69-8(4'-(Hydroxymethyl)biphenyl-3-carboxylic acid)
• 143613-17-6(H2QPBC)
• 176212-48-9(3'-(Hydroxymethyl)biphenyl-3-carboxylic Acid)
• 177734-84-8([1,1'-Biphenyl]-3-carboxylicacid, 3',5'-dimethyl-)
• 158619-46-6(3'-Methylbiphenyl-3-carboxylic acid)
• 612-87-3(3,3'-H2BPDC)