Cas no 221093-45-4 (Estradiol-d)
Estradiol-d Chemical and Physical Properties
Names and Identifiers
-
- Estra-1,3,5(10)-triene-2,4,16,16,17-d5-3,17-diol,(17b)-
- 17β-Estradiol-D5 solution
- A-Estradiol-2,4,16,16,17-d5
- Estradiol-d
- HY-B0141S2
- DTXSID40469516
- CS-0129234
- 17beta-Estradiol-2,4,16,16,17-D5
- 17beta-Estradiol-2,4,16,16,17-d5, 97 atom % D, 99% (CP)
- (8R, 9S, 13S, 14S, 17S)-2, 4, 16, 16, 17-pentadeuterio-13-methyl-6, 7, 8, 9, 11, 12, 14, 15-octahydrocyclopenta[a]phenanthrene-3, 17-diol
- 221093-45-4
- Estradiol-d5
- F90854
- SCHEMBL1882520
- (8R,9S,13S,14S,17S)-2,4,16,16,17-pentadeuterio-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthrene-3,17-diol
- (1S,3aS,3bR,9bS,11aS)-11a-methyl(1,2,2,6,8-H)-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1,7-diol
- DA-49126
- Estra-1,3,5(10)-triene-2,4,16,16,17-d5-3,17-diol, (17ss)-; (17ss)-Estra-1,3,5(10)-triene-2,4,16,16,17-d5-3,17-diol; 17ss-Estradiol-D5; 17ss-Estradiol-2,4,16,16,17-D5
-
- MDL： MFCD01075456
- Inchi： 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1/i3D,7D2,10D,17D
- InChI Key： VOXZDWNPVJITMN-MOKSCAJFSA-N
- SMILES： O[C@@]1([2H])C([2H])([2H])C[C@H]2[C@@H]3CCC4C([2H])=C(C([2H])=CC=4[C@H]3CC[C@@]21C)O
Computed Properties
- Exact Mass: 277.20900
- Monoisotopic Mass: 277.209013734g/mol
- Isotope Atom Count: 5
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 20
- Rotatable Bond Count: 0
- Complexity: 382
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 5
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 4
- Topological Polar Surface Area: 40.5?2
Experimental Properties
- Melting Point: 178-179?°C (lit.)
- Flash Point: Fahrenheit: 35.6 ° f
Celsius: 2 ° c - PSA: 40.46000
- LogP: 3.60920
- Color/Form: 100?μg/mL in acetonitrile
Estradiol-d Security Information
-
Symbol:
- Signal Word：Danger
- Hazard Statement： H350
- Warning Statement： P201-P308+P313
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 45
- Safety Instruction： 53-45
-
Hazardous Material Identification：
- Storage Condition：?20°C
- Risk Phrases：R45
- Safety Term：R53;R45
Estradiol-d Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | E-061-1ML |
Estradiol-d |
221093-45-4 | 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant | 1ML |
2786.59 | 2021-05-13 | |
| TRC | E888006-0.5mg |
17beta-Estradiol-2,4,16,16,17-d5 |
221093-45-4 | 0.5mg |
$ 55.00 | 2023-01-11 | ||
| TRC | E888006-1mg |
17beta-Estradiol-2,4,16,16,17-d5 |
221093-45-4 | 1mg |
$ 82.00 | 2023-09-07 | ||
| TRC | E888006-5mg |
17beta-Estradiol-2,4,16,16,17-d5 |
221093-45-4 | 5mg |
$ 230.00 | 2023-09-07 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | E-061-1ML |
Estradiol-d |
221093-45-4 | 1ml |
￥3413.54 | 2023-05-01 | ||
| Key Organics Ltd | MS-23943-5mg |
Estradiol-d5 |
221093-45-4 | >90% | 5mg |
￡629.67 | 2025-02-09 | |
| Key Organics Ltd | MS-23943-1mg |
Estradiol-d5 |
221093-45-4 | >90% | 1mg |
￡223.98 | 2025-02-09 | |
| Cooke Chemical | S1696549-1l |
17β-Estradiol-D5solution , 100 μg/mLinacetonitrile,ampuleof1 mL,certifiedreferencematerial |
221093-45-4 | Cerilliant | 1l |
RMB 2537.27 | 2025-02-21 | |
| A2B Chem LLC | AF31831-1mg |
17BETA-ESTRADIOL-2,4,16,16,17-D5 |
221093-45-4 | 99% | 1mg |
$155.00 | 2024-04-20 | |
| A2B Chem LLC | AF31831-5mg |
17BETA-ESTRADIOL-2,4,16,16,17-D5 |
221093-45-4 | 99% | 5mg |
$415.00 | 2024-04-20 |
Additional information on Estradiol-d
Estradiol-d: A Comprehensive Overview
Estradiol-d, also known by its CAS number 221093-45-4, is a compound of significant interest in the fields of endocrinology and pharmacology. This compound is a derivative of estradiol, a primary female sex hormone, and has been extensively studied for its potential applications in hormone replacement therapy (HRT) and other medical treatments. The "d" in Estradiol-d denotes the presence of deuterium, a stable isotope of hydrogen, which can influence the compound's pharmacokinetics and bioavailability.
Estradiol is a critical hormone in the female reproductive system, playing a pivotal role in maintaining bone density, cardiovascular health, and cognitive function. The addition of deuterium in Estradiol-d aims to enhance its stability and reduce its rate of metabolism, potentially leading to longer-lasting effects. Recent studies have explored the use of deuterated hormones as a means to improve therapeutic outcomes while minimizing side effects associated with traditional hormone replacement therapies.
The molecular structure of Estradiol-d is similar to that of natural estradiol, with the substitution of hydrogen atoms by deuterium atoms at specific positions. This modification does not alter the compound's ability to bind to estrogen receptors but may affect its metabolic pathways. Research has shown that deuterated hormones can exhibit altered pharmacokinetic profiles compared to their non-deuterated counterparts, which could be advantageous in certain clinical settings.
One of the most promising applications of Estradiol-d lies in its potential use as a diagnostic tool. By incorporating deuterium into the molecule, researchers can track its distribution and metabolism within the body using advanced imaging techniques such as magnetic resonance spectroscopy (MRS). This capability makes Estradiol-d a valuable tool for studying hormone dynamics and assessing therapeutic efficacy in real-time.
In recent years, there has been growing interest in the development of deuterated drugs as a strategy to improve drug safety and efficacy. For instance, studies have demonstrated that deuterated versions of certain medications exhibit reduced toxicity and improved half-lives compared to their non-deuterated counterparts. Applying this principle to Estradiol-d, researchers are exploring its potential as a safer and more effective alternative to conventional hormone replacement therapies.
The synthesis of Estradiol-d involves advanced chemical techniques to ensure precise substitution of hydrogen atoms with deuterium. This process requires meticulous control over reaction conditions to achieve high yields and purity levels. Recent advancements in synthetic chemistry have made it possible to produce Estradiol-d with greater efficiency and consistency, paving the way for large-scale production and clinical trials.
Preclinical studies on Estradiol-d have shown promising results in animal models, particularly in terms of reduced side effects compared to traditional estradiol formulations. These findings suggest that Estradiol-d could offer a safer option for patients requiring long-term hormone replacement therapy. However, further research is needed to confirm these observations in human trials.
In conclusion, Estradiol-d (CAS No. 221093-45-4) represents an exciting advancement in the field of endocrinology. Its unique properties as a deuterated hormone make it a valuable candidate for innovative therapeutic approaches. As research continues to uncover its full potential, Estradiol-d holds promise for improving patient outcomes in hormone-related conditions while minimizing adverse effects.
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