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  Em Canh Pham,Tuong Vi Le Thi,Huong Ha Ly Hong,Bich Ngoc Vo Thi,Long B. Vong,Thao Thanh Vu,Duy Duc Vo,Ngoc Vi Tran Nguyen,Khanh Nguyen Bao Le,Tuyen Ngoc Truong RSC Adv. 2023 13 399
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzimidazoles Benzimidazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzimidazoles

Comprehensive Overview of 2-(Pyridin-4-yl)-1H-1,3-benzodiazole (CAS No. 2208-59-5): Properties, Applications, and Research Insights

2-(Pyridin-4-yl)-1H-1,3-benzodiazole, identified by its CAS number 2208-59-5, is a heterocyclic compound that has garnered significant attention in pharmaceutical and materials science research. This compound, often referred to as a pyridine-benzodiazole derivative, exhibits unique structural features that make it valuable for diverse applications, including drug development, organic electronics, and fluorescence-based sensors. Its molecular framework combines a pyridine ring with a benzodiazole moiety, offering tunable electronic properties and binding affinities.

In recent years, the demand for heterocyclic compounds like 2-(pyridin-4-yl)-1H-1,3-benzodiazole has surged due to their role in designing small-molecule inhibitors and photovoltaic materials. Researchers are particularly interested in its potential as a fluorescent probe for biological imaging, leveraging its stable emission characteristics. Additionally, its ligand properties make it a candidate for metal-organic frameworks (MOFs), a trending topic in nanotechnology and sustainable chemistry.

The synthesis of CAS 2208-59-5 typically involves condensation reactions between 4-pyridinecarboxaldehyde and o-phenylenediamine, followed by oxidative cyclization. This process highlights the compound's adaptability for scalable production, a key consideration for industrial applications. Analytical techniques such as NMR spectroscopy and mass spectrometry are employed to confirm its purity, which is critical for reproducibility in research.

From a pharmacological perspective, 2-(pyridin-4-yl)-1H-1,3-benzodiazole has been explored for its kinase inhibitory activity, aligning with the growing interest in targeted cancer therapies. Its ability to modulate protein-protein interactions also positions it as a promising scaffold for neurodegenerative disease research, a hot topic in 2024 due to rising global health concerns.

Environmental and safety profiles of 2208-59-5 are equally important. Studies indicate low acute toxicity, but proper handling protocols are recommended to avoid inhalation or skin contact. Its stability under ambient conditions makes it suitable for long-term storage, a practical advantage for laboratories.

In summary, 2-(pyridin-4-yl)-1H-1,3-benzodiazole (CAS 2208-59-5) represents a versatile compound bridging multiple scientific disciplines. Its applications span from biomedical research to advanced materials, reflecting the compound's adaptability to cutting-edge innovations. As interdisciplinary research grows, this compound is poised to play a pivotal role in addressing contemporary scientific challenges.

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