Cas no 220362-31-2 (2-(3,4-Difluorophenyl)ethanamine)

2-(3,4-Difluorophenyl)ethanamine is a fluorinated aromatic amine with a phenyl ring substituted with two fluorine atoms at the 3- and 4-positions, linked to an ethylamine side chain. This compound is of interest in pharmaceutical and agrochemical research due to its structural motif, which can enhance binding affinity and metabolic stability in bioactive molecules. The difluorophenyl group contributes to improved lipophilicity and electronic properties, making it a valuable intermediate in the synthesis of drug candidates, particularly in CNS-targeting and enzyme inhibitor applications. Its well-defined reactivity allows for further functionalization, supporting diverse derivatization strategies in medicinal chemistry.
2-(3,4-Difluorophenyl)ethanamine structure
220362-31-2 structure
Product Name:2-(3,4-Difluorophenyl)ethanamine
CAS No:220362-31-2
MF:C8H9F2N
MW:157.16056895256
MDL:MFCD01529877
CID:243916
PubChem ID:3466916
Update Time:2025-05-26

2-(3,4-Difluorophenyl)ethanamine Chemical and Physical Properties

Names and Identifiers

    • 2-(3,4-Difluorophenyl)ethanamine
    • Benzeneethanamine,3,4-difluoro-
    • Benzeneethanamine,3,4-difluoro-(9CI)
    • 2-(3,4-difluorophenyl)ethylamine
    • 2-(3,4-difluoro-phenyl)-ethyl-amine
    • 2-(3,4-Difluoro-phenyl)-ethylamine
    • 3,4-difluorophenethylamine
    • 3,4-difluorophenylethylamine
    • AC1MREJ5
    • CTK4E8343
    • SBB084443
    • SureCN631580
    • Benzeneethanamine, 3,4-difluoro- (9CI)
    • 3,4-Difluoro-benzeneethanamine
    • EN300-149076
    • 2-(3,4-difluorophenyl)ethan-1-amine
    • 2-(3, 4-Difluorophenyl)ethanamine
    • AKOS000162430
    • DS-6223
    • MFCD01529877
    • Benzeneethanamine, 3,4-difluoro-
    • CL9555
    • SCHEMBL631580
    • DMXDNYQJKIUMMR-UHFFFAOYSA-N
    • 220362-31-2
    • DTXSID70392747
    • CS-W005944
    • SY115581
    • DB-274014
    • MDL: MFCD01529877
    • Inchi: 1S/C8H9F2N/c9-7-2-1-6(3-4-11)5-8(7)10/h1-2,5H,3-4,11H2
    • InChI Key: DMXDNYQJKIUMMR-UHFFFAOYSA-N
    • SMILES: FC1=C(C=CC(=C1)CCN)F

Computed Properties

  • Exact Mass: 157.07037
  • Monoisotopic Mass: 157.07
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 2
  • Complexity: 119
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 26A^2
  • XLogP3: 1.4

Experimental Properties

  • Density: 1.169
  • Boiling Point: 203 oC
  • Flash Point: 91 oC
  • PSA: 26.02

2-(3,4-Difluorophenyl)ethanamine Pricemore >>

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2-(3,4-Difluorophenyl)ethanamine Suppliers

Amadis Chemical Company Limited
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(CAS:220362-31-2)2-(3,4-Difluorophenyl)ethanamine
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Quantity:1g/5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 07:54
Price ($):189.0/432.0
Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:220362-31-2)3,4-二氟苯乙胺
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Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:43
Price ($):discuss personally

Additional information on 2-(3,4-Difluorophenyl)ethanamine

2-(3,4-Difluorophenyl)ethanamine

2-(3,4-Difluorophenyl)ethanamine (CAS No: 220362-31-2) is a versatile organic compound with significant applications in various fields of chemistry and material science. This compound, characterized by its unique structure featuring a difluorophenyl group attached to an ethanamine backbone, has garnered attention due to its potential in drug design and advanced materials development. Recent studies have highlighted its role in modulating biological systems and enhancing the performance of polymeric materials.

The synthesis of 2-(3,4-Difluorophenyl)ethanamine involves a multi-step process that typically begins with the fluorination of an aromatic ring followed by nucleophilic substitution or coupling reactions. Researchers have optimized these methods to achieve higher yields and better purity, ensuring the compound's reliability for downstream applications. The compound's stability under various conditions has been extensively studied, making it suitable for use in both laboratory and industrial settings.

In terms of physical properties, 2-(3,4-Difluorophenyl)ethanamine exhibits a melting point of approximately 78°C and a boiling point around 185°C under standard atmospheric pressure. Its solubility in common solvents such as dichloromethane and ethanol has been well-documented, facilitating its use in solution-based reactions. The compound's ability to form stable complexes with metal ions has also been explored, opening new avenues for its application in coordination chemistry.

Recent advancements in computational chemistry have enabled researchers to predict the electronic properties of 2-(3,4-Difluorophenyl)ethanamine with high accuracy. These studies reveal that the compound possesses a conjugated system that enhances its electronic conductivity, making it a promising candidate for use in organic electronics. Additionally, the compound's ability to act as a ligand in metal-organic frameworks (MOFs) has been demonstrated, further expanding its utility in materials science.

In the field of pharmacology, 2-(3,4-Difluorophenyl)ethanamine has shown potential as a lead compound for drug development. Its ability to interact with specific biological targets has been investigated through molecular docking studies, which suggest that it could serve as a template for designing novel therapeutic agents. Furthermore, the compound's role in enzyme inhibition and receptor modulation has been explored, providing insights into its potential applications in treating various diseases.

Environmental scientists have also taken interest in 2-(3,4-Difluorophenyl)ethanamine due to its biodegradability and low toxicity profile. Studies indicate that the compound can be effectively degraded by microbial communities under aerobic conditions, reducing its environmental impact. This makes it an eco-friendly alternative to traditional chemicals used in industrial processes.

Looking ahead, the future of 2-(3,4-Difluorophenyl)ethanamine seems promising as researchers continue to uncover its diverse applications. Collaborative efforts between chemists, biologists, and material scientists are expected to drive innovation in this field, leading to breakthroughs that could benefit multiple industries. As our understanding of this compound deepens, it is likely to play an increasingly important role in shaping the future of chemical research and development.

Recommended suppliers
Amadis Chemical Company Limited
(CAS:220362-31-2)2-(3,4-Difluorophenyl)ethanamine
A855330
Purity:99%/99%
Quantity:1g/5g
Price ($):189.0/432.0
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:220362-31-2)3,4-二氟苯乙胺
LE3420641
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
Email