• 1. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
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  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Overview of 3,4,5-Trifluorobenzyl Alcohol (CAS No. 220227-37-2): Properties, Applications, and Industry Insights

3,4,5-Trifluorobenzyl Alcohol (CAS No. 220227-37-2) is a fluorinated aromatic alcohol with significant relevance in pharmaceutical, agrochemical, and specialty chemical industries. Its unique molecular structure, featuring three fluorine atoms attached to a benzyl alcohol core, makes it a versatile intermediate for synthesizing high-value compounds. The growing demand for fluorinated chemicals in drug discovery and material science has propelled interest in this compound, as evidenced by frequent searches for "3,4,5-Trifluorobenzyl Alcohol synthesis" and "CAS 220227-37-2 suppliers" across academic and industrial platforms.

One of the key drivers behind the popularity of 3,4,5-Trifluorobenzyl Alcohol is its role in modern pharmaceutical intermediates. Fluorine incorporation often enhances drug bioavailability and metabolic stability, making this compound a critical building block for kinase inhibitors and antiviral agents. Recent PubMed studies highlight its use in developing next-generation therapeutics, aligning with the surge in searches for "fluorinated drug intermediates 2024." Researchers also explore its potential in liquid crystal materials, responding to the rising demand for advanced display technologies.

From a chemical perspective, 3,4,5-Trifluorobenzyl Alcohol exhibits notable characteristics: a molecular weight of 174.11 g/mol, melting point range of 38-42°C, and solubility in common organic solvents like dichloromethane and THF. These properties are frequently queried in technical forums under terms such as "3,4,5-Trifluorobenzyl Alcohol solubility" and "CAS 220227-37-2 technical data sheet." The compound's stability under inert atmospheres makes it preferable for multi-step synthetic routes, a feature emphasized in recent green chemistry discussions.

Industrial applications of 3,4,5-Trifluorobenzyl Alcohol extend to electronic chemicals, where its derivatives serve as dielectric additives. This aligns with the semiconductor industry's search trends for "fluorinated aromatic compounds for electronics." Manufacturers have developed improved purification protocols to achieve >99% purity, addressing the need for high-grade materials in sensitive applications. Analytical methods like GC-MS and HPLC-UV are commonly referenced in quality control discussions surrounding CAS 220227-37-2.

The synthesis of 3,4,5-Trifluorobenzyl Alcohol typically involves reduction of corresponding aldehydes or carboxylic acid derivatives using sodium borohydride or lithium aluminum hydride. Patent literature reveals innovative catalytic approaches that reduce heavy metal waste, responding to environmental concerns reflected in searches for "sustainable fluorochemical production." Scale-up challenges and yield optimization remain active research areas, particularly for GMP-compliant production batches.

Market analysts note steady growth in the fluorobenzyl derivatives sector, with 3,4,5-Trifluorobenzyl Alcohol maintaining a niche but expanding presence. Regulatory compliance (REACH, FDA guidelines) frequently appears in procurement discussions, especially among European and North American buyers searching for "compliant fluorinated building blocks." The compound's shelf life and storage conditions (typically 2-8°C under nitrogen) are additional practical considerations for end-users.

Recent advancements in continuous flow chemistry have opened new possibilities for safer handling of 3,4,5-Trifluorobenzyl Alcohol in industrial settings. This technological shift addresses laboratory safety questions often seen in search queries like "handling fluorinated alcohols safely." Meanwhile, academic research explores novel derivatives through click chemistry approaches, expanding the compound's utility in bioconjugation applications.

Quality benchmarks for CAS 220227-37-2 continue to evolve, with leading suppliers now offering comprehensive analytical packages including NMR and residual solvent analysis. These developments respond to the pharmaceutical industry's stringent material qualification requirements, a topic dominating professional chemistry forums. The compound's role in developing PET radiotracers has also gained attention in medical research circles.

Looking forward, 3,4,5-Trifluorobenzyl Alcohol is poised to maintain its importance as fluorine chemistry advances. Emerging applications in battery electrolytes and metal-organic frameworks (MOFs) represent new growth avenues. Industry reports correlate these trends with increasing searches for "fluorinated materials for energy storage," highlighting the compound's potential beyond traditional chemical applications.

• 456-47-3(3-Fluorobenzyl alcohol)
• 85118-05-4((3,4-difluorophenyl)methanol)
• 67640-33-9(2,3,5-Trifluorobenzyl Alcohol)
• 92339-07-6(2,3,5,6-Tetrafluoro-1,4-benzenedimethanol)
• 79538-03-7(2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol)
• 79538-20-8((3,5-difluorophenyl)methanol)
• 53072-18-7(2,3,4,5-Tetrafluorobenzyl alcohol)
• 4084-38-2(2,3,5,6-Tetrafluorobenzyl alcohol)
• 459-56-3(4-Fluorobenzyl Alcohol)
• 440-60-8((Hydroxymethyl)pentafluorobenzene)