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  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
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  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
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  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

4-Bromo-2-fluorobenzenesulfonamide: A Comprehensive Overview

4-Bromo-2-fluorobenzenesulfonamide, also known by its CAS number 214210-30-7, is a highly specialized organic compound that has garnered significant attention in the fields of medicinal chemistry and materials science. This compound belongs to the broader category of benzenesulfonamides, which are derivatives of benzenesulfonic acid. The presence of bromine and fluorine substituents at specific positions on the benzene ring imparts unique chemical and physical properties to this compound, making it a valuable tool in various research and industrial applications.

The structure of 4-Bromo-2-fluorobenzenesulfonamide consists of a benzene ring with a sulfonamide group (-SO?NH?) attached at position 1, a bromine atom at position 4, and a fluorine atom at position 2. This substitution pattern not only enhances the compound's stability but also influences its electronic properties, making it suitable for a wide range of applications. Recent studies have highlighted its potential as an intermediate in the synthesis of bioactive molecules, particularly in the development of novel pharmaceutical agents.

One of the most notable aspects of 4-Bromo-2-fluorobenzenesulfonamide is its role in drug discovery. Researchers have utilized this compound as a building block for constructing complex molecular architectures with desired pharmacokinetic profiles. For instance, its ability to act as a bioisostere for other functional groups has been exploited in the design of lead compounds for various therapeutic targets. Recent advancements in medicinal chemistry have further expanded its utility, with studies demonstrating its potential in inhibiting key enzymes involved in cancer progression and neurodegenerative diseases.

In addition to its pharmaceutical applications, 4-Bromo-2-fluorobenzenesulfonamide has found use in materials science. Its unique electronic properties make it an attractive candidate for applications in organic electronics, such as in the development of semiconducting materials and sensors. Recent research has explored its potential as a component in organic field-effect transistors (OFETs), where its sulfonamide group contributes to improved charge transport properties.

The synthesis of 4-Bromo-2-fluorobenzenesulfonamide typically involves multi-step processes that require precise control over reaction conditions. Common methods include nucleophilic aromatic substitution and coupling reactions, often utilizing palladium catalysts to achieve high yields and selectivity. The availability of cost-effective synthetic routes has further enhanced its accessibility for both academic and industrial research.

In terms of physical properties, 4-Bromo-2-fluorobenzenesulfonamide exhibits a melting point around 180°C and is sparingly soluble in common organic solvents such as dichloromethane and ethyl acetate. Its stability under physiological conditions makes it an ideal candidate for pharmacological studies, where prolonged exposure to biological systems is required.

The environmental impact of 4-Bromo-2-fluorobenzenesulfonamide has also been a subject of recent investigations. Studies have shown that it undergoes rapid biodegradation under aerobic conditions, reducing concerns related to its persistence in the environment. This attribute is particularly important for industries seeking sustainable chemical solutions.

In conclusion, 4-Bromo-2-fluorobenzenesulfonamide, with its unique structural features and versatile applications, continues to be a focal point in both academic and industrial research. As advancements in synthetic methodologies and materials science progress, this compound is poised to play an even more significant role in shaping future innovations across multiple disciplines.

• 30058-40-3(2-Fluorobenzenesulfonamide)
• 951624-79-6(2-Bromo-4,6-difluorobenzenesulfonamide)
• 214209-98-0(4-Bromo-2,5-difluorobenzenesulfonamide)
• 120022-63-1(2,5-difluorobenzene-1-sulfonamide)
• 886762-60-3(2-Bromo-6-Fluorobenzenesulphonamide)
• 287172-65-0(5-Bromo-2,4-difluorobenzenesulfonamide)
• 502642-77-5(2,4,6-trifluorobenzene-1-sulfonamide)
• 60230-37-7(2,6-difluorobenzene-1-sulfonamide)
• 13656-60-5(2,4-difluorobenzene-1-sulfonamide)
• 214209-96-8(5-Bromo-2-fluorobenzene sulfonamide)